The structural study aim to elucidate congenital hearing loss caused by OTOF gene mutation
Project/Area Number |
22791641
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Otorhinolaryngology
|
Research Institution | 独立行政法人国立病院機構東京医療センター(臨床研究センター) (2011) 独立行政法人国立病院機構(東京医療センター臨床研究センター) (2010) |
Principal Investigator |
NAMBA Kazunori 独立行政法人国立病院機構東京医療センター(臨床研究センター), 臨床研究センター, 研究員 (60425684)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 耳科学 / 遺伝子変異 / OTOF / Auditory Neuropathy / 形態 / 難聴 / 蛋白質 / 蝸牛神経 / 内耳 / 立体構造 |
Research Abstract |
In this study, a hypothetical phosphate signaling which is predicted from molecular modeling of Erk1-like structure of Otoferlin was explored using cultured cells and OTOF gene deficient mouse. In morphological investigation of spiral ganglion neuron of OTOF gene deficient mouse cochlea, a novel hypoganglionosis like phenotype was detected. The phenotype has a potential for the first morphological model of Auditory Neuropathy.
|
Report
(3 results)
Research Products
(2 results)
-
[Journal Article]2012
Author(s)
Matsunaga T, Mutai H, Kunishima S, Namba K, Morimoto N, Shinjo Y, Arimoto Y, Kataoka Y, Shintani T, Morita N, Sugiuchi T, Masuda S, Nakano A, Taiji H, Kaga K.
-
Journal Title
Clin Genet
Volume: 82(5)
Issue: 5
Pages: 425-32
DOI
Related Report
Peer Reviewed
-