Development of uveitis therapy with control for CD4+CD25+regulatory T cells

• Project/Area Number: 22791646
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Hokkaido University
• Principal Investigator: HORIE Yukihiro 北海道大学, 大学院・医学研究科, 客員研究員 (80547183)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ぶどう膜炎 / 調節性T細胞

Research Abstract

The purpose of this investigation was to make clear the role and function of regulatory T cells(Treg) expressing folate receptor 4(FR4) which was recently known as a new marker of Tregs, on experimental autoimmune uveoretinitis(EAU) which is an animal model of human uveitis. As suppression of Tregs by administration of anti-FR4 antibody in EAU mouse, the severity of EAU tended to be increased. This result suggested that Tregs expressing FR4 had a role to suppress intraocular inflammations.

Research Products

• [Journal Article] Replication of a microsatellite genome-wide association study of Behcet's disease in a Korean population (2012)
  • Author(s): Horie Y, et al
  • Journal Title: Rheumatology Volume: (印刷中) Issue: 6 Pages: 983-6
  • DOI: 10.1093/rheumatology/ker444
  • Peer Reviewed
• [Journal Article] Evaluation of NLRP1 gene polymorphisms in Vogt-Koyanagi-Harada disease (2011)
  • Author(s): Horie Y, Saito W, Kitaichi N, Miura T, Ishida S, Ohno S
  • Journal Title: Jpn J Ophthalmol Volume: 55 Issue: 1 Pages: 57-61
  • DOI: 10.1007/s10384-010-0887-9
  • NAID: 10029020610
  • Peer Reviewed
• [Journal Article] Investigation of Association between TLR9 Gene Polymorphisms and VKH in Japanese Patients (2011)
  • Author(s): Ito Ryuta; Ota Masao; Meguro Akira, et al
  • Journal Title: OCULAR IMMUNOLOGY AND INFLAMMATION Volume: 19:3 Issue: 3 Pages: 202-205
  • DOI: 10.3109/09273948.2011.553981
  • Peer Reviewed
• [Journal Article] Evaluation of NLRP1 gene polymorphisms in Vogt-Koyanagi-Harada disease (2011)
  • Author(s): Horie Y, et al
  • Journal Title: Japanese Journal of ophthalmology Volume: 55 Pages: 57-61
  • NAID: 10029020610
  • Peer Reviewed
• [Journal Article] Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet disease susceptibility loci (2010)
  • Author(s): Mizuki N, et al.
  • Journal Title: Nature Genetics Volume: 42 Pages: 703-706
  • Peer Reviewed
• [Presentation] PG剤・β遮断剤からトラボプロスト・チモロールマレイン酸塩配合点眼液への切替え効果 (2011)
  • Author(s): 佐藤出、北市伸義、廣瀬茂樹、高野睦子、赤沼正堂、唐尚子、田邉章浩、木下平次郎、堀江幸弘、木嶋理紀、仲昌彦、大口剛司、新田卓也、新明康弘、陳進輝、石田晋
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-10-08
• [Presentation] Microsatellite polymorphism of Behcet in Korean population that was found by genome wide association study (2011)
  • Author(s): Horie Y, et al.
  • Organizer: 26^<th> Asia Pacific Academy of Ophthalmology Congress
  • Place of Presentation: Sydney Convention & Exhibition Center ( Sydney, Australia)
  • Year and Date: 2011-03-21
• [Presentation] Prevalence and diagnosis of retinal vasculitis in Japan (2011)
  • Author(s): Ohno S, et al.
  • Organizer: 26^<th> Asia Pacific Academy of Ophthalmology Congress
  • Place of Presentation: Sydney Convention & Exhibition Center ( Sydney, Australia)
  • Year and Date: 2011-03-21
• [Presentation] TLR4 polymorphisms in Korean Behcet disease (2010)
  • Author(s): Horie Y, et al.
  • Organizer: 14^<th> International Congress of Behcet disease
  • Place of Presentation: Queen Mary大学(London, UK)
  • Year and Date: 2010-07-07