Research of Cotylenin A functions in retinoblastoma cells

• Project/Area Number: 22791649
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Yonezawa women's junior college (2011); Yamagata University (2010)
• Principal Investigator: KASHIWAGI Yoshiko 山形県立米沢女子短期大学, その他部局等, 助手 (90375345)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: コチレニン A / 網膜芽細胞腫 / 神経節細胞 / 抗腫瘍 / 神経保護 / コチレニンA / PAX6

Research Abstract

We found that Cotyelenin A is a potent inhibitor of cell proliferation and apoptosis, and it changes tumor characteristics in retinoblastoma cell lines. Differences in the effect of Cotyelenin A on ocular retinoblastoma tumors and metastatic tumours were observed. However, we could not detect the function of nerves protection in rat retina ganglion cells (RGC5).

Research Products

• [Journal Article] Cotylenin A inhibits cell proliferation and induces apoptosis and PAX6 mRNA transcripts in retinoblastoma cell lines. (2010)
  • Author(s): Kashiwagi Y, Kato N, Sassa T, Nishitsuka K, Yamamoto T, Takamura H, Yamashita H.
  • Journal Title: Molecular Vision Volume: 16 Pages: 970-982
  • Peer Reviewed
• [Journal Article] Cotylenin A inhibits cell proliferation and induces apoptosis and PAX6 mRNA transcripts in retinoblastoma cell lines (2010)
  • Author(s): Y, Kashiwagi, et al
  • Journal Title: Molecular Vision Volume: 16 Pages: 970-982
  • Peer Reviewed