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Personalized medicine for age-related macular degeneration using polymorphisms of VEGF and VEGFR

Research Project

Project/Area Number 22791653
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionKyoto University

Principal Investigator

YAMASHIRO Kenji  京都大学, 医学研究科, 助教 (80399617)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords眼細胞生物学 / 加齢黄斑変性 / 血管内皮前駆細胞 / 遺伝子多型 / 血管内皮増殖因子
Research Abstract

We found that VEGF gene single nucleotide polymorphism rs699946 is associated with the response of age-related macular degeneration(AMD) to anti-VEGF treatment. Our findings suggest that we can predict the outcome of treatment by detecting rs699946, and we can choose best treatment for each AMD patients.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (57 results)

All 2012 2011 2010

All Journal Article (57 results) (of which Peer Reviewed: 27 results)

  • [Journal Article] Significance ofC2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population2012

    • Author(s)
      Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Akagi-Kurashige Y, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, TajimaK, Matsuda F, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53 Pages: 794-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] Macular Choroidal Thickness and Volume in Eyes With Angioid Streaks Measured by Swept Source Optical Coherence Tomography2012

    • Author(s)
      Ellabban AA, Tsujikawa A, Matsumoto A, Ogino K, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N.
    • Journal Title

      Am J Ophthalmol

    • NAID

      120004161067

    • Related Report
      2011 Final Research Report
  • [Journal Article] Relationship between retinalmorphological findings and visual function in age-related macular degeneration2012

    • Author(s)
      Akagi-Kurashige Y, Tsujikawa A, Oishi A, Ooto S, Yamashiro K, Tamura H, Nakata I, Ueda-Arakawa N, Yoshimura N.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

    • Related Report
      2011 Final Research Report
  • [Journal Article] Vascular endothelial growth factor gene polymorphisms and choroidalneovascularization in highly myopic eyes2012

    • Author(s)
      Akagi-Kurashige Y, Kumagai K, Yamashiro K, Nakanishi H, Nakata I, Miyake M, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Yamada R, Matsuda F, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci

    • Related Report
      2011 Final Research Report
  • [Journal Article] Factors Associated With the Response of Age-Related Macular Degeneration to Intravitreal Ranibizumab Treatment2012

    • Author(s)
      Yamashiro K, Tomita K, Tsujikawa A, Nakata I, Akagi-Kurashige Y, Miyake M, Ooto S, Tamura H, Yoshimura N
    • Journal Title

      Am J Ophthalmol

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular endothelial growth factor gene polymorphisms and choroidal neovascularization in highly myopic eyes2012

    • Author(s)
      Akagi-Kurashige Y, Kumagai K, Yamashiro K, Nakanishi H, Nakata I, Miyake M, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Yamada R, Matsuda F, Yoshimura N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: (in press) Issue: 4 Pages: 2349-53

    • DOI

      10.1167/iovs.11-9405

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macular Choroidal Thickness and Volume in Eyes With Angioid Streaks Measured by Swept Source Optical Coherence Tomography2012

    • Author(s)
      Ellabban AA, Tsujikawa A, Matsumoto A, Ogino K, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N
    • Journal Title

      Am J Ophthalmol

      Volume: (in press) Issue: 6 Pages: 1133-1143.e1

    • DOI

      10.1016/j.ajo.2011.12.013

    • NAID

      120004161067

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between retinal morphological findings and visual function in age-related macular degeneration2012

    • Author(s)
      Akagi-Kurashige Y, Tsujikawa A, Oishi A, Ooto S, Yamashiro K, Tamura H, Nakata I, Ueda-Arakawa N, Yoshimura N
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: (in press) Issue: 8 Pages: 68-80

    • DOI

      10.1007/s00417-012-1928-5

    • NAID

      120004873995

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population2012

    • Author(s)
      Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Akagi-Kurashige Y, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53 Issue: 2 Pages: 794-798

    • DOI

      10.1167/iovs.11-8468

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of elastin genepolymorphism to age-related maculardegeneration and polypoidal choroidal vasculopathy2011

    • Author(s)
      Yamashiro K, Mori K, Nakata I, Tsuchihashi T, Horie-Inoue K, Nakanishi H, Tsujikawa A, Saito M, Iida T, Yamada R, Matsuda F, Inoue S, Awata T, Yoneya S, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Pages: 8780-4

    • Related Report
      2011 Final Research Report
  • [Journal Article] Development of polypoidal lesions inage-related macular degeneration2011

    • Author(s)
      Tsujikawa A, Ojima Y, Yamashiro K, Ooto S, Tamura H, Nakata I, Yoshimura N.
    • Journal Title

      Eye(Lond)

      Volume: 25 Pages: 481-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] Association of lesion size and visual prognosis to polypoidal choroidal vasculopathy2011

    • Author(s)
      Tsujikawa A, Ojima Y, Yamashiro K, Nakata I, Ooto S, Tamura H, Nakanishi H, Hayashi H, Otani A, Yoshimura N.
    • Journal Title

      Am J Ophthalmol

      Volume: 151 Pages: 961-972

    • NAID

      120003184066

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Retinal microstructural abnormalities in central serous chorioretinopathy and polypoidal choroidal vasculopathy2011

    • Author(s)
      Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Otani A, Yoshimura N.
    • Journal Title

      Retina

      Volume: 31 Pages: 527-34

    • NAID

      120004225529

    • Related Report
      2011 Final Research Report
  • [Journal Article] Association between the SERPING1 gene and age-related macular degeneration andpolypoidal choroidal vasculopathy in Japanese.2011

    • Author(s)
      Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, MatsuoK, Tajima K, Matsuda F, Yoshimura N.
    • Journal Title

      PLoS One

      Volume: 6 Pages: 19108-19108

    • Related Report
      2011 Final Research Report
  • [Journal Article] Genetic variants in pigment epithelium-derived factor influence response of polypoidal choroidal vasculopathy to photodynamic therapy2011

    • Author(s)
      Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Ooto S, Tamura H, Saito M, SaitoK, Iida T, Oishi A, Kurimoto Y, Matsuda F, Yoshimura N.
    • Journal Title

      Ophthalmology

      Volume: 118 Pages: 1408-15

    • Related Report
      2011 Final Research Report
  • [Journal Article] VEGFgene polymorphism and response tointravitreal bevacizumab and tripletherapy in age-related macular degeneration.2011

    • Author(s)
      Nakata I, Yamashiro K, Nakanishi H, Tsujikawa A, Otani A, Yoshimura N.
    • Journal Title

      Jpn J Ophthalmol

      Volume: 55 Pages: 435-43

    • Related Report
      2011 Final Research Report
  • [Journal Article] Prognostic factors for visual outcomes 2-years after intravitreal bevacizumab for myopicchoroidal neovascularization2011

    • Author(s)
      Nakanishi H, Tsujikawa A, Yodoi Y, Ojima Y, Otani A, Tamura H, Yamashiro K, Ooto S, Yoshimura N.
    • Journal Title

      Eye(Lond)

      Volume: 25 Pages: 375-81

    • Related Report
      2011 Final Research Report
  • [Journal Article] Macular choroidal thickness and volume in normal subjects measured by swept-source optical coherence tomography.2011

    • Author(s)
      Hirata M, Tsujikawa A, Matsumoto A, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Pages: 4971-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] Association of 15q14 and 15q25 with high myopia in Japanese2011

    • Author(s)
      Hayashi H, Yamashiro K, Nakanishi H, Nakata I, Kurashige Y, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Ozaki M, Yamada R, Matsuda F, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Pages: 4853-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] Association of elastin gene polymorphism to age-related macular degeneration and polypoidal choroidal vasculopathy2011

    • Author(s)
      Yamashiro K, Mori K, Nakata I, Tsuchihashi T, Horie-Inoue K, Nakanishi H, Tsujikawa A, Saito M, Iida I, Yamada R, Matsuda F, Inoue S, Awata T, Yoneya S, Yoshimura N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Issue: 12 Pages: 8780-8784

    • DOI

      10.1167/iovs.11-8205

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of polypoidal choroidal vasculopathy with photodynamic therapy combined with intravitreal injections of ranibizumab2011

    • Author(s)
      Tomita K, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Otani A, Nakayama Y, Yoshimura N
    • Journal Title

      Am J Ophthalmol

      Volume: 153 Issue: 1 Pages: 68-80

    • DOI

      10.1016/j.ajo.2011.07.001

    • NAID

      120003726137

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] VEGF gene polymorphism and response to intravitreal bevacizumab and triple therapy in age-related macular degeneration2011

    • Author(s)
      Nakata I, Yamashiro K, Nakanishi H, Tsujikawa A, Otani A, Yoshimura N
    • Journal Title

      Jpn J Ophthalmol

      Volume: 55 Issue: 5 Pages: 435-43

    • DOI

      10.1007/s10384-011-0061-z

    • NAID

      10029688706

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macular choroidal thickness and volume in normal subjects measured by swept-source optical coherence tomography2011

    • Author(s)
      Hirata M, Tsujikawa A, Matsumoto A, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Issue: 8 Pages: 4971-4978

    • DOI

      10.1167/iovs.11-7729

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between the SERPING1 gene and age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese2011

    • Author(s)
      Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N
    • Journal Title

      PLoS One

      Volume: 6 Issue: 4 Pages: e19108-e19108

    • DOI

      10.1371/journal.pone.0019108

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic variants in pigment epithelium-derived factor influence response of polypoidal choroidal vasculopathy to photodynamic therapy2011

    • Author(s)
      Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Ooto S, Tamura H, Saito M, Saito K, Iida T, Oishi A, Kurimoto Y, Matsuda F, Yoshimura N
    • Journal Title

      Ophthalmology

      Volume: 118 Issue: 7 Pages: 1408-15

    • DOI

      10.1016/j.ophtha.2010.12.011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of 15q14 and 15q25 with high myopia in Japanese2011

    • Author(s)
      Hayashi H, Yamashiro K, Nakanishi H, Nakata I, Kurashige Y, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Ozaki M, Yamada R, Matsuda F, Yoshimura N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Issue: 7 Pages: 4853-4858

    • DOI

      10.1167/iovs.11-7311

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of Lesion Size and Visual Prognosis to Polypoidal Choroidal Vasculopathy.2011

    • Author(s)
      Tsujikawa A, Ojima Y, Yamashiro K, Nakata I, Ooto S, Tamura H, Nakanishi H, Hayashi H, Otani A, Yoshimura N.
    • Journal Title

      Am J Ophthalmol.

      Volume: (in press)

    • NAID

      120003184066

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic Variants in Pigment Epithelium-Derived Factor Influence Response of Polypoidal Choroidal Vasculopathy to Photodynamic Therapy.2011

    • Author(s)
      Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Ooto S, Tamura H, Saito M, Saito K, Iida T, Oishi A, Kurimoto Y, Matsuda F, Yoshimura N.
    • Journal Title

      Ophthalmology.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of 15q14 and 15q25 with High Myopia in Japanese.2011

    • Author(s)
      Hayashi H, Yamashiro K, Nakanishi H, Nakata I, Kurashige Y, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Ozaki M, Yamada R, Matsuda F, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retinal microstructural abnormalities in central serous chorioretinopathy and polypoidal choroidal vasculopathy.2011

    • Author(s)
      Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Otani A, Yoshimura N.
    • Journal Title

      Retina.

      Volume: 31 Pages: 527-534

    • NAID

      120004225529

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sterile endophthalmitis after intravitreal injection of bevacizumabobtained from a single batch2010

    • Author(s)
      Yamashiro K, Tsujikawa A, Miyamoto K, Oh H, Otani A, Tamuara H, Ooto S, Sasahara M, Iwama D, Yoshimura N.
    • Journal Title

      Retina

      Volume: 30 Pages: 485-90

    • NAID

      120002949750

    • Related Report
      2011 Final Research Report
  • [Journal Article] Treatment of polypoidal choroidal vasculopathy byintravitreal injection of bevacizumab2010

    • Author(s)
      Tsujikawa A, Ooto S, Yamashiro K, Tamura H, Otani A, Yoshimura N.
    • Journal Title

      Jpn J Ophthalmol

      Volume: 54 Pages: 310-9

    • Related Report
      2011 Final Research Report
  • [Journal Article] Punctate hyper fluorescent spotsassociated with central serouschorioretinopathy as seen on indocyaninegreen angiography2010

    • Author(s)
      Tsujikawa A, Ojima Y, Yamashiro K, Ooto S, Tamura H, Nakagawa S, Yoshimura N.
    • Journal Title

      Retina

      Volume: 30 Pages: 801-9

    • Related Report
      2011 Final Research Report
  • [Journal Article] Intravitreal bevacizumab for type 1 idiopathic macular telangiectasia2010

    • Author(s)
      Takayama K, Ooto S, Tamura H, Yamashiro K, Otani A, Tsujikawa A, Yoshimura N.
    • Journal Title

      Eye(Lond)

      Volume: 24 Pages: 1492-7

    • Related Report
      2011 Final Research Report
  • [Journal Article] Thickness of photoreceptor layers inpolypoidal choroidal vasculopathy and central serous chorioretinopathy2010

    • Author(s)
      Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Yoshimura N.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 248 Pages: 1077-86

    • Related Report
      2011 Final Research Report
  • [Journal Article] High-resolution imaging of resolved central serous chorioretinopathy using adaptive optics scanning laserophthalmoscopy2010

    • Author(s)
      Ooto S, Hangai M, Sakamoto A, Tsujikawa A, Yamashiro K, Ojima Y, Yamada Y, Mukai H, Oshima S, Inoue T, Yoshimura N.
    • Journal Title

      Ophthalmology

      Volume: 117 Pages: 1809-2

    • Related Report
      2011 Final Research Report
  • [Journal Article] Restoration of outer segments of foveal photoreceptors after resolution of central serouschorioretinopathy2010

    • Author(s)
      Ojima Y, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Yoshimura N.
    • Journal Title

      Jpn J Ophthalmol

      Volume: 54 Pages: 55-60

    • Related Report
      2011 Final Research Report
  • [Journal Article] Joint effect of cigarette smoking and CFH andLOC387715/HTRA1 polymorphisms onpolypoidal choroidal vasculopathy2010

    • Author(s)
      Nakanishi H, Yamashiro K, Yamada R, Gotoh N, Hayashi H, Nakata I, Saito M, Iida T, Oishi A, Kurimoto Y, Matsuo K, Tajima K, Matsuda F, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 51 Pages: 6183-7

    • Related Report
      2011 Final Research Report
  • [Journal Article] Single-nucleotide polymorphisms in the promoter region of matrixmetalloproteinase-1,-2, and-3 in Japanese with high myopia.2010

    • Author(s)
      Nakanishi H, Hayashi H, Yamada R, Yamashiro K, Nakata I, Shimada N, Ohno-Matsui K, Mochizuki M, Ozaki M, Yoshitake S, Kuriyama S, Saito M, Iida T, Matsuo K, Matsuda F, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 51 Pages: 4432-6

    • Related Report
      2011 Final Research Report
  • [Journal Article] ARMS2/HTRA1 and CFHpolymorphisms are not associated withchoroidal neovascularization in highly myopic eyes of the elderly Japanese population2010

    • Author(s)
      Nakanishi H, Gotoh N, Yamada R, Yamashiro K, Otani A, Hayashi H, Tsujikawa A, Shimada N, Ohno-Matsui K, Mochizuki M, Saito M, Saito K, Iida T, Matsuda F, Yoshimura N.
    • Journal Title

      Eye(Lond)

      Volume: 24 Pages: 1078-84

    • Related Report
      2011 Final Research Report
  • [Journal Article] Relationship between retinal sensitivity and morphologic changes in eyes with confluent soft drusen2010

    • Author(s)
      Iwama D, Tsujikawa A, Ojima Y, Nakanishi H, Yamashiro K, Tamura H, Ooto S, Yoshimura N.
    • Journal Title

      Clin Experiment Ophthalmol

      Volume: 38 Pages: 483-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] Macular hole formation following photodynamic therapycombined with intravitreal injection of bevacizumab and triamcinolone acetonide2010

    • Author(s)
      Iwama D, Ooto S, Tsujikawa A, Yamashiro K, Yoshimura N.
    • Journal Title

      Jpn J Ophthalmol

      Volume: 54 Pages: 364-6

    • Related Report
      2011 Final Research Report
  • [Journal Article] CFH and ARMS2 variations in age-related macularde generation, polypoidal choroidal vasculopathy, and retinal angiomatous proliferation2010

    • Author(s)
      Hayashi H, Yamashiro K, Gotoh N, Nakanishi H, Nakata I, Tsujikawa A, OtaniA, Saito M, Iida T, Matsuo K, Tajima K, Yamada R, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 51 Pages: 5914-9

    • Related Report
      2011 Final Research Report
  • [Journal Article] Prognostic factors of vitreous hemorrhage secondary to exudative age-related maculardegeneration2010

    • Author(s)
      Hasegawa T, Otani A, Sasahara M, Gotoh N, Ooto S, Tamura H, Yamashiro K, Tsujikawa A, Yoshimura N.
    • Journal Title

      Am J Ophthalmol.

      Volume: 149 Pages: 322-329

    • NAID

      120001823762

    • Related Report
      2011 Final Research Report
  • [Journal Article] Haplotypeanalysis of the ARMS2/HTRA1 region in Japanese patients with typicalneovascular age-related macular degeneration or polypoidal choroidal vasculopathy.2010

    • Author(s)
      Gotoh N, Yamashiro K, Nakanishi H, Saito M, Iida T, Yoshimura N.
    • Journal Title

      Jpn J Ophthalmol.

      Volume: 54 Pages: 609-14

    • Related Report
      2011 Final Research Report
  • [Journal Article] Genetic variants near TIMP3 and high-densitylipoprotein-associated loci influence susceptibility to age-related macular degeneration.2010

    • Author(s)
      Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA, Campochiaro PA, Klein ML, Tan PL, Conley YP, Kanda A, Kopplin L, Li Y, Augustaitis KJ, Karoukis AJ, Scott WK, Agarwal A, Kovach JL, Schwartz SG, Postel EA, BrooksM, Baratz KH, Brown WL, Brucker AJ, OrlinA, Brown G, Ho A, Regillo C, Donoso L, TianL, Kaderli B, Hadley D, Hagstrom SA, Peachey NS, Klein R, Klein BE, Gotoh N, Yamashiro K, Ferris Iii F, Fagerness JA, Reynolds R, Farrer LA, Kim IK, Miller JW, Corton M, Carracedo A, Sanchez-Salorio M, Pugh EW, Doheny KF, Brion M, Deangelis MM, Weeks DE, Zack DJ, Chew EY, Heckenlively JR, Yoshimura N, Iyengar SK, Francis PJ, Katsanis N, Seddon JM, Haines JL, Gorin MB, Abecasis GR, Swaroop A.
    • Journal Title

      Proc Natl Acad Sci USA.

      Volume: 107 Pages: 7401-6

    • Related Report
      2011 Final Research Report
  • [Journal Article] Haplotype analysis of the ARMS2/HTRA1 region in Japanese patients with typical neovascular age-related macular degeneration or polypoidal choroidal vasculopathy.2010

    • Author(s)
      Gotoh N, Yamashiro K, Nakanishi H, Saito M, Iida T, Yoshimura N.
    • Journal Title

      Jpn J Ophthalmol.

      Volume: 54 Pages: 609-614

    • NAID

      10027666485

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macular hole formation following photodynamic therapy combined with intravitreal injection of bevacizumab and triamcinolone acetonide.2010

    • Author(s)
      Iwama D, Ooto S, Tsujikawa A, Yamashiro K, Yoshimura N.
    • Journal Title

      Jpn J Ophthalmol.

      Volume: 54 Pages: 364-366

    • NAID

      10027204735

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of polypoidal choroidal vasculopathy by intravitreal injection of bevacizumab.2010

    • Author(s)
      Tsujikawa A, Ooto S, Yamashiro K, Tamura H, Otani A, Yoshimura N.
    • Journal Title

      Jpn J Ophthalmol.

      Volume: 54 Pages: 310-319

    • NAID

      10027204523

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Joint effect of cigarette smoking and CFH and LOC387715/HTRA1 polymorphisms on polypoidal choroidal vasculopathy.2010

    • Author(s)
      Nakanishi H, Yamashiro K, Yamada R, Gotoh N, Hayashi H, Nakata I, Saito M, Iida T, Oishi A, Kurimoto Y, Matsuo K, Tajima K, Matsuda F, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 51 Pages: 6183-6187

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-resolution imaging of resolved central serous chorioretinopathy using adaptive optics scanning laser ophthalmoscopy.2010

    • Author(s)
      Ooto S, Hangai M, Sakamoto A, Tsujikawa A, Yamashiro K, Ojima Y, Yamada Y, Mukai H, Oshima S, Inoue T, Yoshimura N.
    • Journal Title

      Ophthalmology.

      Volume: 117 Pages: 1800-1809

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between retinal sensitivity and morphologic changes in eyes with confluent soft drusen.2010

    • Author(s)
      Iwama D, Tsujikawa A, Ojima Y, Nakanishi H, Yamashiro K, Tamura H, Ooto S, Yoshimura N.
    • Journal Title

      Clin Experiment Ophthalmol.

      Volume: 38 Pages: 483-488

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CFH and ARMS2 variations in age-related macular degeneration, polypoidal choroidal vasculopathy, and retinal angiomatous proliferation.2010

    • Author(s)
      Hayashi H, Yamashiro K, Gotoh N, Nakanishi H, Nakata I, Tsujikawa A, Otani A, Saito M, Iida T, Matsuo K, Tajima K, Yamada R, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 51 Pages: 5914-5919

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-nucleotide polymorphisms in the promoter region of matrix metal loproteinase-1, -2, and -3 in Japanese with high myopia.2010

    • Author(s)
      Nakanishi H, Hayashi H, Yamada R, Yamashiro K, Nakata I, Shimada N, Ohno-Matsui K, Mochizuki M, Ozaki M, Yoshitake S, Kuriyama S, Saito M, Iida T, Matsuo K, Matsuda F, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 51 Pages: 4432-4436

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.2010

    • Author(s)
      Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA, Campochiaro PA, Klein ML, Tan PL, Conley YP, Kanda A, Kopplin L, Li Y, Augustaitis KJ, Karoukis AJ, Scott WK, Agarwal A, Kovach JL, Schwartz SG, Postel EA, Brooks M, Baratz KH, Brown WL ; Complications of Age-Related Macular Degeneration Prevention Trial Research Group, Brucker AJ, Orlin A, Brown G, Ho A, Regillo C, Donoso L, Tian L, Kaderli B, Hadley D, Hagstrom SA, Peachey NS, Klein R, Klein BE, Gotoh N, Yamashiro K, Ferris Iii F, Fagerness JA, Reynolds R, Farrer LA, Kim IK, Miller JW, Corton M, Carracedo A, Sanchez-Salorio M, Pugh EW, Doheny KF, Brion M, Deangelis MM, Weeks DE, Zack DJ, Chew EY, Heckenlively JR, Yoshimura N, Iyengar SK, Francis PJ, Katsanis N, Seddon JM, Haines JL, Gorin MB, Abecasis GR, Swaroop A.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 107 Pages: 7401-7406

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thickness of photoreceptor layers in polypoidal choroidal vasculopathy and central serous chorioretinopathy.2010

    • Author(s)
      Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Yoshimura N.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol.

      Volume: 248 Pages: 1077-1086

    • NAID

      120002514711

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Punctate hyperfluorescent spots associated with central serous chorioretinopathy as seen on indocyanine green angiography.2010

    • Author(s)
      Tsujikawa A, Ojima Y, Yamashiro K, Ooto S, Tamura H, Nakagawa S, Yoshimura N.
    • Journal Title

      Retina

      Volume: 30 Pages: 801-809

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed

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Published: 2010-08-23   Modified: 2016-04-21  

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