Comprehensive Assessment for improvement of QOL and effectiveness brought by AMD treatment.

• Project/Area Number: 22791655
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Kyoto University
• Principal Investigator: TAMURA Hiroshi 京都大学, 医学研究科, 助教 (40418760)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 加齢黄斑変性 / QOL / 脈絡膜新生血管 / 新生血管 / 強度近視 / 近視性脈絡膜新生血管 / 中心性漿液性網脈絡膜症

Research Abstract

New findings of age-related macular degeneration or its relative disease such as central serous chorioretinopathy and choroidal neovascularization secondary to angioid streaks are found to understand the pathophysiologies of these desease. Experiences in comparative effectiveness research for cataract surgery were successfully applied to age-related macular degeneration treatment. New findings of effectiveness in treatment for AMD were also revealed from the relationship between second eye involvement of AMD and ARMS2 genotype.

Research Products

• [Journal Article] Factors Associated with the Response of Age-related Macular Degeneration to Intravitreal Ranibizumab Treatment (2012)
  • Author(s): Yamashiro K, Tomita K, Tsujikawa A, Nakata I, Akagi-Kurashige Y, Miyake M, Ooto S, Tamura H, Yoshimura N.
  • Journal Title: Am J Ophthalmol Volume: 154 Issue: 1 Pages: 125-36
  • DOI: 10.1016/j.ajo.2012.01.010
  • Peer Reviewed
• [Journal Article] Relationship between retinal morphological findings and visual function in age-related macular degeneration (2012)
  • Author(s): Akagi-Kurashige Y, Tsujikawa A, Oishi A, Ooto S, Yamashiro K, Tamura H, Nakata I, Ueda-Arakawa N, Yoshimura N
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: (in press) Issue: 8 Pages: 68-80
  • DOI: 10.1007/s00417-012-1928-5
  • NAID: 120004873995
  • Peer Reviewed
• [Journal Article] Idiopathic macular telangiectasia ; microperimetry, retinal structure ; photoreceptor inner and outer segment junction line ; optical coherence tomo graphy (2012)
  • Author(s): Takayama K, Ooto S, Tamura H, et a.l
  • Journal Title: Retina Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Eye Care Comparative Effectiveness Research Team(ECCERT). Cost-effectiveness of cataract surgery in Japan (2011)
  • Author(s): Hiratsuka Y, Yamada M, Murakami A, Okada AA, Yamashita H, Ohashi Y, Yamagishi N, Tamura H, Fukuhara S, Takura T
  • Journal Title: Jpn J Ophthalmol Volume: 55(4) Issue: 4 Pages: 333-42
  • DOI: 10.1007/s10384-011-0041-3
  • Peer Reviewed
• [Journal Article] Association of lesion size and visual prognosis to polypoidal choroidal vasculopathy (2011)
  • Author(s): Tsujikawa A, Ojima Y, Yamashiro K, Nakata I, Ooto S, Tamura H, Nakanishi H, Hayashi H, Otani A, Yoshimura N
  • Journal Title: Am J Ophthalmol Volume: 151 Issue: 6 Pages: 961-972
  • DOI: 10.1016/j.ajo.2011.01.002
  • NAID: 120003184066
  • Peer Reviewed
• [Journal Article] Genetic variants in pigment epithelium-derived factor influence response of polypoidal choroidal vasculopathy to photodynamic therapy (2011)
  • Author(s): Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Ooto S, Tamura H, Saito M, Saito K, Iida T, Oishi A, Kurimoto Y, Matsuda F, Yoshimura N
  • Journal Title: Ophthalmology Volume: 118 Issue: 7 Pages: 1408-15
  • DOI: 10.1016/j.ophtha.2010.12.011
  • Peer Reviewed
• [Journal Article] Prognostic factors for visual outcomes 2-years after intravitreal bevacizumab for myopic choroidal neovascularization (2011)
  • Author(s): Nakanishi H, Tsujikawa A, Yodoi Y, Ojima Y, Otani A, Tamura H, Yamashiro K, Ooto S, Yoshimura N.
  • Journal Title: Eye(Lond) Volume: 25(3) Issue: 3 Pages: 375-81
  • DOI: 10.1038/eye.2010.226
  • Peer Reviewed
• [Journal Article] Development of polypoidal lesions in age-related macular degeneration (2011)
  • Author(s): Tsujikawa A, Ojima Y, Yamashiro K, Ooto S, Tamura H, Nakata I, Yoshimura N.
  • Journal Title: Eye(Lond) Volume: 25(4) Issue: 4 Pages: 481-8
  • DOI: 10.1038/eye.2010.232
  • Peer Reviewed
• [Journal Article] Retinal microstructural abnormalities in central serous chorioretinopathy and polypoidal choroidal vasculopathy (2011)
  • Author(s): Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Otani A, Yoshimura N.
  • Journal Title: Retina Volume: 31(3) Pages: 527-34
  • NAID: 120004225529
  • Peer Reviewed
• [Journal Article] Treatment of polypoidal choroidal vasculopathy with photodynamic therapy combined with intravitreal injections of ranibizumab (2011)
  • Author(s): Tomita K, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Otani A, Nakayama Y, Yoshimura N
  • Journal Title: Am J Ophthalmol Volume: 153 Issue: 1 Pages: 68-80
  • DOI: 10.1016/j.ajo.2011.07.001
  • NAID: 120003726137
  • Peer Reviewed
• [Journal Article] Prognostic factors for visual outcomes 2-years after intravitreal bevacizumab for myopic choroidal neovascularization. (2011)
  • Author(s): Nakanishi H, Tsujikawa A, Yodoi Y, Ojima Y, Otani A, Tamura H, et al.
  • Journal Title: Eye Volume: 25 Pages: 375-381
  • Peer Reviewed
• [Journal Article] Development of polypoidal lesions in age-related macular degeneration. (2011)
  • Author(s): Tsujikawa A, Ojima Y, Yamashiro K, Ooto S, Tamura H, et al.
  • Journal Title: Eye Volume: (In press)
  • Peer Reviewed
• [Journal Article] Retinal microstructural abnormalities in central serous chorioretinopathy and polypoidal choroidal vasculopathy. (2011)
  • Author(s): Ooto S, Tsujikawa A, Mori S, Tamura H, et al.
  • Journal Title: Retina Volume: 31 Pages: 827-834
  • NAID: 120004225529
  • Peer Reviewed
• [Journal Article] Treatment of Polypoidal Choroidal Vasculopathy with Intravitreal Injection of Bevacizumab (2010)
  • Author(s): Tsujikawa A, Ooto S, Yamashiro K, Tamura H, Otani A, Yoshimura N.
  • Journal Title: Jpn J Ophthalmol Volume: 54(4) Issue: 4 Pages: 310-9
  • DOI: 10.1007/s10384-010-0813-1
  • Peer Reviewed
• [Journal Article] Relationship between retinal sensitivity and morphologic changes in eyes with confluent soft drusen (2010)
  • Author(s): Iwama D, Tsujikawa A, Ojima Y, Nakanishi H, Yamashiro K, Tamura H, Ooto S, Yoshimura N.
  • Journal Title: Clin Experiment Ophthalmol Volume: 38(5) Issue: 5 Pages: 483-8
  • DOI: 10.1111/j.1442-9071.2010.02294.x
  • Peer Reviewed
• [Journal Article] Intravitreal bevacizumab for type 1 idiopathic macular telangiectasia (2010)
  • Author(s): Takayama K, Ooto S, Tamura H, Yamashiro K, Otani A, Tsujikawa A, Yoshimura N.
  • Journal Title: Eye(Lond) Volume: 24(9) Issue: 9 Pages: 1492-7
  • DOI: 10.1038/eye.2010.61
  • Peer Reviewed
• [Journal Article] Treatment of Polypoidal Choroidal Vasculopathy with Intravitreal Injection of Bevacizumab (2010)
  • Author(s): Tsujikawa A, Ooto S, Yamashiro K, Tamura H, et al.
  • Journal Title: Jpn J Ophthalmol Volume: 54 Pages: 310-319
  • Peer Reviewed
• [Journal Article] Relationship between retinal sensitivity and morphologic changes in eyes with confluent soft drusen. (2010)
  • Author(s): Iwama D, Tsujikawa A, Ojima Y, Nakanishi H, Yamashiro K, Tamura H, Ooto S, Yoshimura N.
  • Journal Title: Clin Experiment Ophthalmol. Volume: 38 Pages: 483-488
  • Peer Reviewed
• [Journal Article] Intravitreal bevacizumab for type 1 idiopathic macular telangiectasia. (2010)
  • Author(s): Takayama K, Ooto S, Tamura H, et al.
  • Journal Title: Eye Volume: 24 Pages: 1492-1497
  • Peer Reviewed
• [Journal Article] Idiopathic macular telangiectasia ; microperimetry, retinal structure ; photoreceptor inner and outer segment junction line ; optical coherence tomography.
  • Author(s): Takayama K, Ooto S, Tamura H, Yamashiro K, Otani A, Tsujikawa A, Yoshimura N.
  • Journal Title: Retina Volume: (in press)
  • Peer Reviewed
• [Presentation] 弾性線維性仮性黄色腫症患者の疫学調査ならびにABCC 6遺伝子変異の解析:中間報告I (2011)
  • Author(s): 岩永聰、与崎マリ子、八木洋輔、原肇秀、室賀絵里、谷岡未樹、北岡隆、築城英子、田村寛
  • Organizer: 第43回日本結合組織学会学術大会、第58回マトリックス研究会大会
  • Place of Presentation: 大分
  • Year and Date: 2011-06-10
• [Presentation] 弾性線維性仮性黄色腫症患者の疫学調査ならびにABCC6遺伝子変異の解析:中間報告I (2011)
  • Author(s): 岩永聰、与崎マリ子、八木洋輔、原肇秀、室賀絵里、谷岡未樹、北岡隆、築城英子、田村寛, ら
  • Organizer: 第43回日本結合組織学会学術大会第58回マトリックス研究会大会
  • Place of Presentation: 大分
  • Year and Date: 2011-06-10
• [Presentation] ポリープ状脈絡膜血管症の予後と分類 (2010)
  • Author(s): 尾島優美子、辻川明孝、大谷篤史、山城健児、田村寛, ら
  • Organizer: 第64回日本臨床眼科学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-11
• [Presentation] 日本人の加齢黄斑変性における僚眼発症とARMS2遺伝子多型の関連性 (2010)
  • Author(s): 田村寛, ら
  • Organizer: 第64回日本臨床眼科学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-11
• [Presentation] 加齢黄斑変性に対するbavacizumab硝子体内投与の治療効果とVEGF遺伝子多型との相関 (2010)
  • Author(s): 仲田勇夫、山城健児、中西秀雄、林寿子、辻川明孝、大谷篤史、大音壮太郎、田村寛、吉村長久
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-16
• [Presentation] 加齢黄斑変性の病型とCFH遺伝子およびARMS2遺伝子の多型との相関 (2010)
  • Author(s): 林寿子、山城健児、中西秀雄、仲田勇夫、辻川明孝、大谷篤史、大音壮太郎、田村寛, ら
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-15