Development of new neuroprotective treatments for glaucoma

• Project/Area Number: 22791656
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Kyoto University
• Principal Investigator: IKEDA Hanako 京都大学, 医学研究科, 助教 (20372162)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 眼科 / 緑内障 / 治療 / 神経保護

Research Abstract

Glaucoma, the most major cause of vision loss in Japan, is characterized by progressive visual field loss due to loss of retinal ganglion cells. Inhibitors for VCP has been elucidated to have neuroprotective effect and to delay disease progression on mouse models of glaucoma. They might be new neuroprotective drugs for glaucoma patients.

Research Products

• [Journal Article] Longitudinal and simultaneous imaging of retinal ganglion cells and inner retinal layers in a mouse model of glaucoma induced by N-methyl-D-aspartate. (2011)
  • Author(s): Nakano N, Ikeda OH, Hangai M, Muraoka Y, Toda Y, Kakizuka A, Yoshimura N.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 52 Issue: 12 Pages: 8754-62
  • DOI: 10.1167/iovs.10-6654
  • Peer Reviewed
• [Presentation] VCP阻害剤によるマウス網膜神経節細胞傷害モデルにおける神経保護効果の検討 (2012)
  • Author(s): 中野紀子、池田華子、ら4名
  • Organizer: 第116回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-06
• [Presentation] VCP阻害剤によるマウス網膜神経節細胞傷害モデルにおける神経保護効果の検討 (2012)
  • Author(s): 中野紀子、池田華子, ら4名
  • Organizer: 116回日本眼科学会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2012-04-05
• [Presentation] HRA、OCT同時撮影によるGLAST欠損マウス網膜神経節細胞障害の経時変化 (2011)
  • Author(s): 中野紀子、池田華子, ら4名
  • Organizer: 115回日本眼科学会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2011-05-13
• [Presentation] OCT同時撮影によるGLAST欠損マウス網膜神経節細胞障害の経時変化 (2010)
  • Author(s): 中野紀子、池田華子、ら4名、HRA
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-16
• [Presentation] Imaging of retinal nerve fiber layer and inner retinal segment in the DBA/2J mouse model of glaucoma by using spectral-domain optical coherence tomography with speckle noise reduction(スペクトラルドメインOCTを用いた緑内障モデルマウスDBA2Jの網膜神経線維層および網膜内層のイメージング) (2010)
  • Author(s): Hanako Ohashi Ikeda
  • Organizer: 2010 ARVO(The Association for Research in Vision and Ophthalmology) meeting(国際視覚眼科学会)
  • Place of Presentation: アメリカ、フロリダ州
  • Year and Date: 2010-05-02
• [Presentation] Speckle-noise-reduced Spectral-domain Optical coherence tomography.(Thy1-CFPマウスを用いた網膜神経節細胞および網膜内層のイメージング) (2010)
  • Author(s): Noriko Nakano, Hanako Ohashi Ikeda, ら他2名
  • Organizer: 2010 ARVO(The Association for Research in Vision and Ophthalmology) meeting(国際視覚眼科学会)
  • Place of Presentation: アメリカ、フロリダ州
  • Year and Date: 2010-05-02
• [Presentation] Imaging of retinal nerve fiber layer and inner retinal segment in the DBA/2J mouse model of glaucoma by using spectral-domain optical coherence tomography with speckle noise reduction.(スペクトラルドメインOCTを用いた緑内障モデルマウスDBA2Jの網膜神経線維層および網膜内層のイメージング) (2010)
  • Author(s): 池田華子
  • Organizer: 2010 ARVO (The Association for Research in Vision and Ophthalmology) meeting(国際視覚眼科学会)
  • Place of Presentation: アメリカフロリダ州
  • Year and Date: 2010-05-02
• [Patent(Industrial Property Rights)] 眼疾患処置薬 (2012)
  • Inventor(s): 垣塚彰池田華子ら他5名
  • Industrial Property Rights Holder: 京都大学ダイトーケミックス
  • Filing Date: 2012-09-30
  • Overseas
• [Patent(Industrial Property Rights)] 眼疾患処置薬 (2011)
  • Inventor(s): 垣塚彰、池田華子, 他5名
  • Industrial Property Rights Holder: 京都大学・ダイトーケミックス株式会社
  • Filing Date: 2011-09-30
  • Overseas
• [Patent(Industrial Property Rights)] 眼疾患処置薬 (2010)
  • Inventor(s): 垣塚彰池田華子ら他5名
  • Industrial Property Rights Holder: 京都大学ダイトーケミックス
  • Industrial Property Number: 2010-221873
  • Filing Date: 2010-09-30
• [Patent(Industrial Property Rights)] 眼疾患処置薬 (2010)
  • Inventor(s): 垣塚彰、池田華子、中野紀子、吉村長久、首藤敏之、淵上智弘
  • Industrial Property Rights Holder: 京都大学・ダイトーケミックス株式会社
  • Industrial Property Number: 2010-221873
  • Filing Date: 2010-09-30