Study of electrical stimulation therapy for optic neuropathies

• Project/Area Number: 22791658
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Osaka University
• Principal Investigator: MORIMOTO Takeshi 大阪大学, 医学(系)研究科(研究院), 准教授 (00530198)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 神経保護 / 電気刺激治療 / 網膜神経節細胞 / 視神経疾患 / 網膜神経保護 / 難治性視神経症 / 電気刺激 / IGF-1 / 視神経

Research Abstract

In the present study, I investigated the mechanism underlying electrical stimulation -induced neuroprotection of retinal ganglion cells and examined the effect of electrical stimulation on various optic neuropathies. I elucidated that retinal neurovascular coupling was activated by electrical stimulation to exert neuroprotection. And moreover I found that about 30% of patients improved their vision after electrical stimulation treatment. Finally I established the protocol of electrical stimulation therapy for various optic neuropathies.

Research Products

• [Journal Article] Characteristics of retinal reflectance changes induced by transcorneal electrical stimulation in cat eyes (2014)
  • Author(s): Morimoto T, 他7名
  • Journal Title: PLoS One Volume: 9
• [Journal Article] Characteristics of retinal reflectance changes induced by transcorneal electrical stimulation in cat eyes (2014)
  • Author(s): Morimoto Takeshi, Kanda H, Miyoshi T, Hirohara Y, Mihashi T, Kitaguchi Y, Nishida K, Fujikado T
  • Journal Title: PLOS ONE Volume: 9 Issue: 3 Pages: 1-11
  • DOI: 10.1371/journal.pone.0092186
  • Peer Reviewed / Open Access
• [Journal Article] 内斜視術後患者における3D映像の立体感 (2013)
  • Author(s): 遠藤 高生, 森本 壮 (3), 他2名
  • Journal Title: 臨床眼科 Volume: 67 Pages: 1489-1494
• [Journal Article] 壮年期に発症した視神経乳頭近傍の網膜細動脈瘤破裂の1例 (2013)
  • Author(s): 浅尾 和伸, 森本 壮(3),他2名
  • Journal Title: 眼科臨床紀要 Volume: 6 Pages: 725-728
  • NAID: 40019804782
• [Journal Article] Feasibility of 2nd generation STS retinal prosthesis in dogs (2013)
  • Author(s): Fujikado T, Morimoto T (5), 他9名
  • Journal Title: Conf Proc IEEE Eng Med Biol Soc. Volume: 2013 Pages: 3119-3121
• [Journal Article] Optical imaging of retina in response to grating stimuli in cats (2013)
  • Author(s): Hirohara Y, Morimoto T (4), 他5名
  • Journal Title: Exp Eye Res Volume: 109 Pages: 1-7
• [Journal Article] Berkeley Rudimentary Vision Test(BRVT)を用いた超低視力の定量化の試み (2013)
  • Author(s): 中村美紗子, 森本壮 (6), 他5名
  • Journal Title: 眼科臨床紀要 Volume: 6 Pages: 49-54
• [Journal Article] Feasibility of 2nd generation STS retinal prosthesis in dogs. (2013)
  • Author(s): Fujikado T, Kamei M, Sakaguchi H, Kanda H, Morimoto T, Nishida K, Kishima H, Maruo T, Oosawa K, Ozawa M, Nishida K
  • Journal Title: Conf Proc IEEE Eng Med Biol Soc Volume: Jul Pages: 3119-3121
  • DOI: 10.1109/embc.2013.6610201
  • Peer Reviewed
• [Journal Article] Optical imaging of retina in response to grating stimuli in cats (2013)
  • Author(s): Hirohara Y, Mihashi T, Kanda H, Morimoto T, Miyoshi T, Wolffsohn JS, Fujikado T
  • Journal Title: Exp Eye Res Volume: 109 Pages: 1
  • DOI: 10.1016/j.exer.2013.01.007
  • Peer Reviewed
• [Journal Article] Role of Electrical Activity of Neurons for Neuroprotection (2012)
  • Author(s): Morimoto T
  • Journal Title: Int Rev Neurobiol Volume: 105 Pages: 19-38
• [Journal Article] Transcorneal Electrical Stimulation Promotes Survival of Photoreceptors and Improves Retinal Function in Rhodopsin P347L Transgenic Rabbits (2012)
  • Author(s): Morimoto T, 他5名
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 53 Pages: 4254-4261
• [Journal Article] Serial measurements of accommodation by open-field Hartmann-Shack wavefront aberrometer in eyes with accommodative spasm (2012)
  • Author(s): Kanda H, Morimoto T (4), 他4名
  • Journal Title: Jpn J Ophthalmol Volume: 56 Pages: 617-623
  • NAID: 10031126911
• [Journal Article] Adaptive optics dioptric scanning ophthalmoscope with a wider field of view similar to those of normal ophthalmoscopes (2012)
  • Author(s): Yamaguchi T, Morimoto T (5), 他4名
  • Journal Title: Opt Lett. Volume: 37 Pages: 2496-2498
• [Journal Article] 【神経眼科-診断から治療へ-】視神経疾患に対する電気刺激療法 (2012)
  • Author(s): 森本 壮
  • Journal Title: 神経眼科 Volume: 29 Pages: 276-285
• [Journal Article] Transcorneal electrical stimulation promotes survival of photoreceptors and improves retinal function in rhodopsin P347L transgenic rabbits. (2012)
  • Author(s): Morimoto T
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 53 Issue: 7 Pages: 4254-4261
  • DOI: 10.1167/iovs.11-9067
  • Peer Reviewed
• [Journal Article] Role of Electrical Activity of Neurons for Neuroprotection (2012)
  • Author(s): Morimoto T
  • Journal Title: International Review of Neurobiology Volume: 105 Pages: 19-38
  • Peer Reviewed
• [Journal Article] Serial measurements of accommodation by open-field Hartmann-Shack wavefront aberrometer in eyes with accommodative spasm (2012)
  • Author(s): Kanda H
  • Journal Title: Jpn J Ophthalmol Volume: 56 Issue: 6 Pages: 617
  • DOI: 10.1007/s10384-012-0187-7
  • NAID: 10031126911
  • Peer Reviewed
• [Journal Article] Adaptive optics dioptric scanning ophthalmoscope with a wider field of view similar to those of normal ophthalmoscopes (2012)
  • Author(s): Yamaguchi T
  • Journal Title: Opt Lett Volume: 37 Issue: 13 Pages: 2496
  • DOI: 10.1364/ol.37.002496
  • Peer Reviewed
• [Journal Article] 【神経眼科-診断から治療へ-】 視神経疾患に対する電気刺激療法 (2012)
  • Author(s): 森本 壮
  • Journal Title: 神経眼科 Volume: 29 Pages: 276-285
• [Journal Article] 【神経眼科-最新の話題】 非動脈炎性虚血性視神経症に経角膜電気刺激治療は有効か? (2012)
  • Author(s): 森本 壮
  • Journal Title: あたらしい眼科 Volume: 29 Pages: 771-776
• [Journal Article] Chronic implantation of newly developed suprachoroidal-transretinal stimulation (STS) prosthesis in dogs (2011)
  • Author(s): Morimoto T, 他11名
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 52 Pages: 6785-6792
• [Journal Article] Testing of Semi-chronically Implanted Retinal Prosthesis by Suprachoroidal-Transretinal Stimulation in Patients with Retinitis Pigmentosa (2011)
  • Author(s): Fujikado T, Morimoto T(5), 他11名
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 52 Pages: 4726-4733
• [Journal Article] 本態性眼瞼痙攣診断例におけるドライアイ合併の割合 (2011)
  • Author(s): 山本定徳, 森本 壮 (2), 他4名
  • Journal Title: 眼科臨床紀要 Volume: 4 Pages: 738-741
  • NAID: 10031162581
• [Journal Article] 若年成人におけるピレンゼピン点眼薬の瞳孔および調節に与える影響 (2011)
  • Author(s): 川口佳菜, 森本 壮 (3), 他6名
  • Journal Title: 眼科臨床紀要 Volume: 5 Pages: 21-26
  • NAID: 40019184920
• [Journal Article] Chronic implantation of newly developed suprachoroidal-transretinal stimulation (STS) prosthesis in dogs (2011)
  • Author(s): Morimoto T
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 52(9) Issue: 9 Pages: 6785-92
  • DOI: 10.1167/iovs.10-6971
  • Peer Reviewed
• [Journal Article] Testing of semichronically implanted retinal prosthesis by suprachoroidal-transretinal stimulation in patients with retinitis pigmentosa (2011)
  • Author(s): Fujikado T
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 52(7) Issue: 7 Pages: 4726-33
  • DOI: 10.1167/iovs.10-6836
  • Peer Reviewed
• [Journal Article] Development of anisometropia in patients after surgery for esotropia. (2010)
  • Author(s): Fujikado T
  • Journal Title: Jpn J Ophthalmol. Volume: 54 Pages: 589-593
  • Peer Reviewed
• [Presentation] 網膜色素変性に対する経角膜電気刺激治療 (2013)
  • Author(s): 森本 壮
  • Organizer: 第61回日本臨床視覚電気生理学会
  • Place of Presentation: 千里ライフサイエンスセンター 大阪
  • Invited
• [Presentation] Evaluation of residual retinal preservation by using transcorneal electrical stimulation and optical coherence tpmography in patients with advanced retinitis pigmentosa, candidates for retinal prosthesis (2013)
  • Author(s): Takeshi Morimoto
  • Organizer: Artificial vision 2013
  • Place of Presentation: Aachen Germaney
• [Presentation] 難治性視神経疾患に対する治療戦略 (2012)
  • Author(s): 森本 壮
  • Organizer: 第50回日本神経眼科学会
  • Place of Presentation: 京都
  • Invited
• [Presentation] 網膜色素変性に対する経角膜電気刺激治療の臨床応用 (2012)
  • Author(s): 森本 壮
  • Organizer: 世界網膜会議
  • Place of Presentation: 岡山
  • Invited
• [Presentation] Evaluation Of Retinal Reflectance Changes Elicited By Transcorneal Electrical Stimulation In Cat Eyes (2012)
  • Author(s): Morimoto T
  • Organizer: ARVO2012 （米国視覚科学会議）
  • Place of Presentation: Florida USA
• [Presentation] ラマン分光法を用いたグルタミン酸による培養網膜神経節細胞の細胞死の観察 (2012)
  • Author(s): 森本 壮
  • Organizer: 第116回日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] 後肢懸垂ラットにおける頭部への体液シフトの眼球に対する影響 (2012)
  • Author(s): 森本 壮
  • Organizer: 第58回日本宇宙航空環境医学会大会
  • Place of Presentation: 豊橋
• [Presentation] 視神経疾患に対する電気刺激治療 (2011)
  • Author(s): 森本壮
  • Organizer: 第49回日本神経眼科学会総会
  • Place of Presentation: 神戸国際会議場(招待講演)
  • Year and Date: 2011-11-26
• [Presentation] Feasibility of chronically implanted retinal prosthesis by suprachoroidal-transretinal stimulation in patients with advanced retinitis pigmentosa (2011)
  • Author(s): Morimoto T
  • Organizer: 2nd Korea-Japan SCEV joint meeting
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-11-19
  • Invited
• [Presentation] Feasibility of chronically implanted retinal prosthesis by suprachoroidal-transretinal stimulation in patients with advanced retinitis pigmentosa (2011)
  • Author(s): Morimoto T
  • Organizer: The 2^<nd> KSCEV & JSCEV joint meeting
  • Place of Presentation: Soeul South Korea(招待講演)
  • Year and Date: 2011-11-19
• [Presentation] 網膜色素変性の残存網膜内層機能の評価-経角膜電気刺激検査と網膜厚の関連の検討 (2011)
  • Author(s): 森本壮, 他
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2011-10-07
• [Presentation] ロドプシンP347Lトランスジェニックウサギ眼に対する経角膜電気刺激の神経保護効果 (2011)
  • Author(s): 森本壮, 他
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2011-05-12
• [Presentation] 高次収差と弱視 (2011)
  • Author(s): 森本壮
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム(招待講演)
  • Year and Date: 2011-05-12
• [Presentation] Transcorneal Electrical Stimulation Promotes The Survival Of Photoreceptors And Preserves Retinal Function In Rhodopsin P3471 Trans genie Rabbits (2011)
  • Author(s): Morimoto T, et al
  • Organizer: 2011 AEVO Annual Meeting
  • Place of Presentation: Fortlauderdale USA
  • Year and Date: 2011-04-22
• [Presentation] 網膜電気刺激による視覚回復 (2011)
  • Author(s): 森本壮
  • Organizer: 近畿斜視弱視アフタヌーンセミナー
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2011-02-26
• [Presentation] 甲状腺眼症による眼瞼後退に対して保存強膜を用いた瞼板延長術を施行した1例 (2010)
  • Author(s): 森本香・森本壮
  • Organizer: 第48回日本神経眼科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-11-27
• [Presentation] 網膜色素変性症患者に対する経角膜電気刺激を用いた残存網膜内層機能の評価-人工視覚装置埋植試験の結果との比較検討 (2010)
  • Author(s): 森本壮
  • Organizer: 第48回日本神経眼科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-11-27
• [Presentation] 脈絡膜上経網膜電気刺激型人工視覚システム体内装置埋植後の視機能の変化 (2010)
  • Author(s): 森本壮
  • Organizer: 第64回日本臨床眼科学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-12
• [Presentation] 経角膜電気刺激によるネコ眼の網膜内因性シグナルの変化 (2010)
  • Author(s): 森本壮
  • Organizer: 第58回日本臨床視覚電気生理学会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-10-08
• [Presentation] 人工視覚の動物モデルの電気生理学的解析 (2010)
  • Author(s): 森本壮
  • Organizer: 第58回日本臨床視覚電気生理学会
  • Place of Presentation: 盛岡(招待講演)
  • Year and Date: 2010-10-08
• [Presentation] 眼球脱臼により重度の角膜障害をきたし瞼縁切除術を併用した瞼板縫合術を施行したCrouzon症候群の1例 (2010)
  • Author(s): 照林彩・森本壮
  • Organizer: 第35回日本小児学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-02
• [Presentation] Semi-chronic Implantation of Artificial Retina by Suprachoroidal Transretinal Stimulation (STS) System In Dog (2010)
  • Author(s): Morimoto T
  • Organizer: ARVO2010
  • Place of Presentation: フォートローダデール 米国
  • Year and Date: 2010-05-02
• [Presentation] 軸索切断された網膜神経節細胞に対するPeroxiredoxin6の神経保護効果 (2010)
  • Author(s): 森本壮
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-16
• [Presentation] GPA(Granulomatosis with Polyangiitis)が疑われた鼻性視神経症の1例
  • Author(s): 遠藤 高生, 森本 壮, 他3名
  • Organizer: 第51回日本神経眼科学会
  • Place of Presentation: 秋田
• [Presentation] Evaluating the Relationship between Retinal Damage and Electrical Stimulation Intensity with Suprachoroidal-Transretinal Stimulation
  • Author(s): Kanda H, Morimoto T, 他3名
  • Organizer: 3rd International Conference on medicalbionics Engineering Solutinos for Neural Disorders
  • Place of Presentation: Silverwater Resort, Phillip Island, Australia
• [Presentation] Feasibility of 2nd Generation STS Retinal Prosthesis in dogs
  • Author(s): Fujiakdo T, Kamei M, Sakaguchi H, Kanda H, Morimoto T, 他7名
  • Organizer: Artificial Vision 2013 : The International Symposium on Visual Prosthetics
  • Place of Presentation: Aachen, Germany
• [Presentation] Intraocular Pressure and Retinal Vascular Changes during Transient Exposure to Microgravity in Adult Rats
  • Author(s): Morimoto T, 他5名
  • Organizer: 34th Annual Meeting International Gravitational Physiology
  • Place of Presentation: Toyohashi Japan
• [Presentation] Evaluation of localization test under simulated very low vision conditions
  • Author(s): Endo T, Morimoto T, 他4名
  • Organizer: ARVO2013 Seattle
  • Place of Presentation: USA
• [Presentation] In situ monitoring cytochrome c in dying RGC-5 cells by Raman microscopy
  • Author(s): Morimoto T, 他7名
  • Organizer: ARVO2013 Seattle
  • Place of Presentation: USA
• [Presentation] Evaluation of safety of porous surface electrodes for STS Retinal prosthesis
  • Author(s): Kanda H, Morimoto T, 他4名
  • Organizer: ARVO2013 Seattle
  • Place of Presentation: USA
• [Presentation] 多孔化処理を施した人工網膜用刺激電極の安全性評価
  • Author(s): 神田 寛行, 森本 壮, 他4名
  • Organizer: 第117回日本眼科学会
  • Place of Presentation: 東京
• [Presentation] 超低視力者における到達運動のLocalization testによる評価
  • Author(s): 遠藤 高生, 森本 壮, 他4名
  • Organizer: 第117回日本眼科学会
  • Place of Presentation: 東京
• [Presentation] 軸索切断された網膜神経節細胞に対する Peroxiredoxin6 の酸化ストレス防御と神経保護
  • Author(s): 森本 壮, 他8名
  • Organizer: 第117回日本眼科学会
  • Place of Presentation: 東京
• [Presentation] 網膜色素変性に対する電気刺激治療
  • Author(s): 森本 壮
  • Organizer: 第61回日本臨床視覚電気生理学会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 難治性視神経疾患の病態と治療
  • Author(s): 森本 壮
  • Organizer: 第26回大阪市大眼科研究会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 難治性視神経疾患に対する治療戦略
  • Author(s): 森本 壮
  • Organizer: 日本神経眼科学会 50周年記念講演会シンポジウム
  • Place of Presentation: 京都
  • Invited
• [Presentation] 難治性視神経疾患の病態と治療
  • Author(s): 森本 壮
  • Organizer: 第26回大阪市大眼科研究会
  • Place of Presentation: 大阪市立総合医療センター
  • Invited
• [Presentation] 難治性視神経疾患の診断と治療
  • Author(s): 森本 壮
  • Organizer: 大阪医科大学オープンカンファレンス
  • Place of Presentation: 大阪
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/sensory/www/