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The involvement of ocular surface barrier in allergic conjunctival diseases

Research Project

Project/Area Number 22791664
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionKochi University

Principal Investigator

FUKUDA Ken  高知大学, 教育研究部・医療学系, 准教授 (70335751)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsアレルギー / 上皮細胞 / バリアー / サイトカイン / マウス / 角膜 / 結膜 / 細胞・組織 / 角結膜
Research Abstract

Among Th2 cytokines, IL-4 and IL-13, but not IL-5, IL-9, or IL-10, induced a significant decrease of barrier function in cultured human corneal epithelial cells. In a mouse model of allergic conjunctivitis using ragweed pollen, allergen challenge caused a decrease in expression of the junctional protein, E-cadherin, by conjunctival epithelium.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (45 results)

All 2012 2011 2010 Other

All Journal Article (28 results) (of which Peer Reviewed: 27 results) Presentation (17 results)

  • [Journal Article] Resolution of photoreceptor outer segment damage in a patient with unilateral acute idiopathic maculopathy observed using spectral-domain optical coherence tomography2012

    • Author(s)
      Matsushita E, Fukuda K, Nakahira A, Kishi S, Fukushima A.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 250(5) Pages: 765-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronic noninfectious uveitis associated with Vogt-Koyanagi-Harada disease treated with low-dose weekly systemic methotrexate2012

    • Author(s)
      Kondo Y, Fukuda K, Suzuki K, Nishida T.
    • Journal Title

      Jpn J Ophthalmol

      Volume: 56(1) Pages: 104-6

    • NAID

      10030248578

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] B and T lymphocyte attenuator regulates the development of antigen-induced experimental conjunctivitis2012

    • Author(s)
      Ishida W, Fukuda K, Kajisako M, Sumi T, Matsuda H, Yagita H, Fukushima A.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 250(2) Pages: 289-95

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Resolutionof pliotoreceptor outer segment damage in a patient with unilateral acute idiopathic maculopathy observed using spectral domein optical coherence tomography2012

    • Author(s)
      Matsushita E, et al
    • Journal Title

      Graefe's Arch Clin Exp Ophthalmol

      Volume: (印刷中) Issue: 5 Pages: 765-768

    • DOI

      10.1007/s00417-011-1796-4

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] B and T lymphocyte attenuator regulates the development of antigen-induced experimental conjunctivitis2012

    • Author(s)
      Ishida W, et al
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 250 Issue: 2 Pages: 289-295

    • DOI

      10.1007/s00417-011-1695-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of experimental autoimmune uveoretinitis by anti-delta-like ligand 4 monoclonal antibody2011

    • Author(s)
      Ishida W, Fukuda K, Sakamoto S, Koyama N, Koyanagi A, Yagita H, Fukushima A.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52(11) Pages: 8224-30

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term follow-up after lamellar keratoplasty in a patient with bilateral idiopathic corneal keloid2011

    • Author(s)
      Fukuda K, Chikama T, Takahashi M, Nishida T.
    • Journal Title

      Cornea

      Volume: 30(12) Pages: 1491-4

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic induction of eotaxin and VCAM-1 expression in human corneal fibroblasts by staphylococcal peptidoglycan and either IL-4 or IL-132011

    • Author(s)
      Fukuda K, Nishida T, Fukushima A.
    • Journal Title

      Allergol Int

      Volume: 60(3) Pages: 355-63

    • NAID

      130004723048

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adjuvants determine the contribution of basophils to antigen sensitization in vivo2011

    • Author(s)
      Ishida W, Fukuda K, Sumi T, Ebihara N, Kajisako M, Matsuda H, Yagita H, Fukushima A.
    • Journal Title

      Immunol Lett

      Volume: 136(1) Pages: 49-54

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic changes of microRNAs in the eye during the development of experimental autoimmune uveoretinitis2011

    • Author(s)
      Ishida W, Fukuda K, Higuchi T, Kajisako M, Sakamoto S, Fukushima A.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52(1) Pages: 611-7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic induction of eotaxin and VCAM-1 expression in human corneal fibroblasts by staphylococcal peptidoglycan and either IL-4 or IL-132011

    • Author(s)
      Fukuda K, et al
    • Journal Title

      Allergol Int

      Volume: 60 Pages: 191-203

    • NAID

      130004723048

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of experimental autoimmune uveoretinitis by anti-Delta-like ligand 4 monoclonal antibody2011

    • Author(s)
      Ishida W, et al
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Issue: 11 Pages: 8224-823

    • DOI

      10.1167/iovs.11-7756

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term follow-up after lamellar keratoplasty in a patient with bilateral idiopathic corneal keloid2011

    • Author(s)
      Fukuda K, et al
    • Journal Title

      Cornea

      Volume: 30 Issue: 12 Pages: 1491-1494

    • DOI

      10.1097/ico.0b013e31822018f2

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adjuvants determine the contribution of basophils to antigen sensitization in vivo2011

    • Author(s)
      Ishida W, et al
    • Journal Title

      Immunol Lett

      Volume: 136 Issue: 1 Pages: 49-54

    • DOI

      10.1016/j.imlet.2010.12.002

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic changes of microRNAs in the eye during the development of experimental autoimmune uveoretinitis.2011

    • Author(s)
      Ishida W, et al.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Pages: 611-617

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adjuvants determine the contribution of basophils to antigen sensitization in vivo.2011

    • Author(s)
      Ishida W, et al
    • Journal Title

      Immunol Lett

      Volume: 136 Pages: 49-54

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic induction of eotaxin and VCAM-1 expression in human corneal fibroblasts by staphylococcal peptidoglycan and either IL-4 or IL-132011

    • Author(s)
      Fukuda K, et al.
    • Journal Title

      Allergol Int

      Volume: (印刷中)

    • NAID

      130004723048

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] B and T lymphocyte attenuator regulates the development of antigen induced experimental conjunctivitis2011

    • Author(s)
      Ishida W, et al
    • Journal Title

      Graefe's Arch Clin Exp Ophthalmol

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conjunctival macrophages act as antigen-presenting cells in the conjunctiva during the development of experimental allergic conjunctivitis2010

    • Author(s)
      Ishida W, Fukuda K, Kajisako M, Takahashi A, Sumi T, van Rooijen N, Fukushima A.
    • Journal Title

      Mol Vis

      Volume: 16 Pages: 1280-5

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Case report of restoration of the corneal epithelium in a patient with atopic keratoconjunctivitis resulting in amelioration of ocular allergic inflammation2010

    • Author(s)
      Fukuda K, Yamada N, Nishida T.
    • Journal Title

      Allergol Int

      Volume: 59(3) 309-12 Pages: 309-12

    • NAID

      10029670872

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition by tranilast of the cytokine-induced expression of chemokines and the adhesion molecule VCAM-1 in human corneal fibroblasts2010

    • Author(s)
      Adachi T, Fukuda K, Kondo Y, Nishida T.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 51(8) Pages: 3954-60

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Levels of soluble CD14 and lipopolysaccharide-binding protein in human basal tears2010

    • Author(s)
      Fukuda K, Kumagai N, Nishida T.
    • Journal Title

      Jpn J Ophthalmol

      Volume: 54(3) Pages: 241-2

    • NAID

      10027204206

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ocular allergic inflammation : interaction between the cornea and conjunctiva.2010

    • Author(s)
      Fukuda K, et al.
    • Journal Title

      Cornea

      Volume: 29

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Inhibition by tranilast of the cytokine-induced expression : of chemokines and the adhesion molecule VCAM-1 in human corneal fibroblasts.2010

    • Author(s)
      Adachi, et al.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 51 Pages: 3954-3960

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Levels of soluble CD14 and lipopolysaccharide-binding protein in human basal tears.2010

    • Author(s)
      Fukuda K, et al.
    • Journal Title

      Jpn J Ophthalmol

      Volume: 54 Pages: 241-242

    • NAID

      10027204206

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conjunctival macrophages act as antigen-presenting cells in the conjunctiva during the development of experimental allergic conjunctivitis.2010

    • Author(s)
      Ishida W, et al.
    • Journal Title

      Mol Vis

      Volume: 16 Pages: 1280-1285

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Case report of restoration of the corneal epithelium in a patient with atopic keratoconjunctivitis resulting in amelioration of ocular allergic inflammation.2010

    • Author(s)
      Fukuda K, et al.
    • Journal Title

      Allergol Int

      Volume: 59 Pages: 309-312

    • NAID

      10029670872

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The murine CCR3 receptor regulates both eosinophilia and hyperresponsiveness in IgE-mediated allergic conjunctivitis

    • Author(s)
      Fukuda K, Kuo CH, Morohoshi K, Liu FT, Ono SJ.
    • Journal Title

      Br J Ophthalmol

      Volume: (印刷中)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 緑膿菌臨床分離株に対するバクテリオファージKPP12の溶菌効果の検討2012

    • Author(s)
      福田憲他
    • Organizer
      角膜カンファランス2012
    • Place of Presentation
      ホテルニューオータニ(東京都)
    • Year and Date
      2012-02-24
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 抗原特異的免疫療法による眼アレルギー治療の可能性2012

    • Author(s)
      福田憲
    • Organizer
      角膜カンファランス2012(シンポジウム)
    • Place of Presentation
      ホテルニューオータニ(東京都)
    • Year and Date
      2012-02-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 抗原特異的免疫療法による眼アレルギー治療の可能性2012

    • Author(s)
      福田憲
    • Organizer
      角膜カンファランス2012
    • Place of Presentation
      ホテルニューオータニ(東京都)(シンポジウム)(招待講演)
    • Year and Date
      2012-02-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Immunomodulation in severe allergic conjunctivitis2012

    • Author(s)
      Ken Fukuda
    • Organizer
      World Ophthalmology Congress 2012(シンポジウム)
    • Place of Presentation
      The Abu Dhabi National Exhibition center.(Abu Dhabi, U. A. E.)
    • Year and Date
      2012-02-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Immunomodulation in severe allergic conjunctivitis2012

    • Author(s)
      Ken Fukuda
    • Organizer
      World Ophthalmology Congress 2012
    • Place of Presentation
      The Abu Dhabi National Exhibition center (Abu Dhabi, U.A.E.)(シンポジウム)(招待講演)
    • Year and Date
      2012-02-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Immunomodulatory treatment of severe ocular allergies2011

    • Author(s)
      Ken Fukuda
    • Organizer
      The 11th International Ocular Inflammation Society Congress(シンポジウム)
    • Place of Presentation
      Hotel Taj Exotica(Goa, India)
    • Year and Date
      2011-11-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Immunomodulatory treatment of severe ocular allergies2011

    • Author(s)
      Ken Fukuda
    • Organizer
      The 11th International Ocular Inflammation Society Congress
    • Place of Presentation
      Hotel Taj Exotica (Goa, India)(シンポジウム)(招待講演)
    • Year and Date
      2011-11-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肥満細胞再構築マウスを用いたアレルギー性結膜疾患の研究2011

    • Author(s)
      福田憲
    • Organizer
      第61回日本アレルギー学会秋季学術大会(シンポジウム)
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Year and Date
      2011-11-10
    • Related Report
      2011 Final Research Report
  • [Presentation] 肥満細胞再構築マウスを用いたアレルギー性結膜疾患の研究2011

    • Author(s)
      福田憲
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)(シンポジウム)(招待講演)
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] バクテリオファージによるマウス緑膿菌角膜炎の抑制効果2011

    • Author(s)
      福田憲,石田わか,角環,森田珠恵,内山淳平,松崎茂展,大畑雅典,福島敦樹
    • Organizer
      第48回日本眼感染症学会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-07-08
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] トラニラストによる角膜線維芽細胞からのサイトカイン産生抑制作用2011

    • Author(s)
      福田憲,足立格郁,近藤由樹子,西田輝夫,福島敦樹
    • Organizer
      第115回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2011-05-12
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] マウスエンドトキシン角膜炎における角膜内サイトカイン・ケモカインの動態2011

    • Author(s)
      福田憲, ほか
    • Organizer
      第35回日本角膜学会総会
    • Place of Presentation
      品川プリンスホテル(東京都)
    • Year and Date
      2011-02-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Interleukin-4 or interleukin-13 impairs barrier function in cultured human corneal epithelial cells.2010

    • Author(s)
      Fukuda K, et al.
    • Organizer
      2^<nd> Asia Cornea Society Biennial Scientific Meeting
    • Place of Presentation
      ウェスティンホテル(京都)
    • Year and Date
      2010-12-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] アレルギー性結膜炎モデルマウスにおけるFcεRIα陽性細胞の関与2010

    • Author(s)
      福田憲, ほか
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2010-11-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 角膜プラーク下に感染性角膜潰瘍を生じた春季カタルの2例2010

    • Author(s)
      福田憲, ほか
    • Organizer
      第64回日本臨床眼科学会
    • Place of Presentation
      国際会議場(兵庫県)
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Interaction with eosinophils promotes chemokine and extracellular matrix synthesis by conjunctival fibroblasts2010

    • Author(s)
      Fukuda K, et al.
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      国際会議場(兵庫県)
    • Year and Date
      2010-08-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 実験的アレルギー性結膜炎発症におけるFcεRIα陽性細胞の果たす役割2010

    • Author(s)
      福田憲, ほか
    • Organizer
      第44回日本眼炎症学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-07-09
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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