Suppression of inflammation with the cornea infection by the control of the natural immunity
| Project/Area Number |
22791666
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Kochi University |
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Principal Investigator |
SUMI Tamaki 高知大学, 教育研究部・医療学系, 助教 (70385243)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 角膜感染症 / 緑膿菌 / 角膜炎 / サイトカイン / 好中球 / 免疫学 / 眼炎症 |
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| Research Abstract |
Keratitis was induced by the application of LPS in C57BL/ 6 mice. Time-points of infiltration into cornea differed between macrophages and neutrophils. Similarly, humoral factors such as cytokines and chemokines were detected at different time-point. I made a mouse model of Pseudomonas aeruginosa(P. aeruginosa.) keratitis. Severe keratitis was induced by 5x10^6 of CFU P. aeruginosa.(clinical separation). The average clinical score of keratitis was lower in the BALB/ c than C57BL/ 6 mice.
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Report
(3 results)
Research Products
(28 results)
