Early Detection of Retinal Pigment Epithelium Abnormalities Using Near-Infrared Fundus Autofluorescence Photography

• Project/Area Number: 22791676
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: KOIZUMI Hideki 京都府立医科大学, 医学部附属病院, 専攻医 (20551500)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 眼底自発蛍光 / 網膜色素上皮 / 黄斑 / 近赤外光 / 網膜感度

Research Abstract

Near-infrared fundus autofluorescence photography detected more widespread abnormal areas of retinal pigment epithelium than the conventional method using blue-light did. The abnormal autofluorescent findings corresponded to the areas with decreased retinal sensitivity. Near-infrared fundus autofluorescence photography may be a useful method to detect early metabolic changes of retinal pigment epithelium which possibly result in visual impairment.

Research Products

• [Journal Article] Fundus autofluorescence in polypoidal choroidal vasculopathy (2012)
  • Author(s): Yamagishi T, Koizumi H, et al
  • Journal Title: Ophthalmology Volume: (In press) Issue: 8 Pages: 1650-1657
  • DOI: 10.1016/j.ophtha.2012.02.016
  • Peer Reviewed
• [Journal Article] Blue light and near-infrared fundus autofluorescence in acute Vogt-Koyanagi-Harada disease (2011)
  • Author(s): Koizumi H, Maruyama K, Kinoshita S
  • Journal Title: Br J Ophthalmol Volume: 94 Pages: 1499-1505
  • Peer Reviewed
• [Journal Article] Blue light and near-infrared fundus autofluorescence in acute Vogt-Koyanagi-Harada disease (2011)
  • Author(s): Koizumi H, et al.
  • Journal Title: British Journal of Ophthalmology Volume: 94 Pages: 1499-1505
  • Peer Reviewed
• [Journal Article] Fundus autofluorescence in polypoidal choroidal vasculopathy
  • Author(s): Yamagishi T, Koizumi H, Yamazaki T, Kinoshita S
  • Journal Title: Ophthalmology Volume: (In press)
  • Peer Reviewed
• [Presentation] 滲出型加齢黄斑変性診療のパラダイムシフト (2012)
  • Author(s): 古泉英貴
  • Organizer: Mie Ophthalmic Seminar
  • Place of Presentation: 津市
  • Year and Date: 2012-01-08
• [Presentation] 滲出型加齢黄斑変性診療のパラダイムシフト (2012)
  • Author(s): 古泉英貴
  • Organizer: Mie Ophthalmic Seminar
  • Place of Presentation: 三重
  • Year and Date: 2012-01-08
• [Presentation] ポリープ状脈絡膜血管症の眼底自発蛍光とスペクトラルドメイン光干渉断層像の比較 (2011)
  • Author(s): 山岸哲哉, 他
  • Organizer: TEAM2011
  • Place of Presentation: 東京都
  • Year and Date: 2011-12-02
• [Presentation] ポリープ状脈絡膜血管症の眼底自発蛍光とスペクトラルドメイン光干渉断層像の比較 (2011)
  • Author(s): 山岸哲哉、古泉英貴, ら
  • Organizer: TEAM2011
  • Place of Presentation: 東京
  • Year and Date: 2011-12-02
• [Presentation] ポリープ状脈絡膜血管症の眼底自発蛍光所見 (2010)
  • Author(s): 山岸哲哉, 他
  • Organizer: 第64回日本臨床眼科学会
  • Place of Presentation: 神戸市
  • Year and Date: 2010-11-13
• [Book] 専門医のための眼科診療クオリファイ第4巻加齢黄斑変性:診断と治療の最先端 (2011)
  • Author(s): 古泉英貴
  • Publisher: 中山書店
• [Book] 専門医のための眼科診療クオリファイ第4巻加齢黄斑変性:診断と治療の最先端 (2011)
  • Author(s): 古泉英貴(分担)
  • Total Pages: 2
  • Publisher: 中山書店