Development of new treatment for age-related macular degeneration with suppressing scaring.

Research Project

Project/Area Number	22791679
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Ophthalmology
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	YONEDA Kazuhito 京都府立医科大学, 医学部附属病院, 専攻医 (00347460)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	眼病理 / 加齢黄斑変性 / リンパ管 / TGF-beta / 眼病理学
Research Abstract	We have challenged to develop new therapeutic method for age-related macular degeneration that is a leading cause of irreversible blindness in the developed world. Firstly, we found that CTLA2alpha suppressed the choroidal neovascularization. Secondly, we found that trans-pupillary thermotherapy(TTT) that had beed already applied in a clinical setting restore Bruch membrane integrity and barrier function against new vessel growth. Additionally we found that PPARgamma suppressed epithelial mesenchymal transition of human RPE cell.