Development of new treatment for age-related macular degeneration with suppressing scaring.
| Project/Area Number |
22791679
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
YONEDA Kazuhito 京都府立医科大学, 医学部附属病院, 専攻医 (00347460)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 眼病理 / 加齢黄斑変性 / リンパ管 / TGF-beta / 眼病理学 |
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| Research Abstract |
We have challenged to develop new therapeutic method for age-related macular degeneration that is a leading cause of irreversible blindness in the developed world. Firstly, we found that CTLA2alpha suppressed the choroidal neovascularization. Secondly, we found that trans-pupillary thermotherapy(TTT) that had beed already applied in a clinical setting restore Bruch membrane integrity and barrier function against new vessel growth. Additionally we found that PPARgamma suppressed epithelial mesenchymal transition of human RPE cell.
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Report
(3 results)
Research Products
(2 results)
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[Journal Article] Heat treatment of retinal pigment epithelium induces production of elastic lamina components and antiangiogenic activity2012
Author(s)
Sekiyama E, Saint-Geniez M, Yoneda K, Hisatomi T, Nakao S, Walshe TE, Maruyama K, Hafezi-Moghadam A, Miller JW, Kinoshita S, D' Amore PA
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Journal Title
FASEB journal
Volume: 26巻
Issue: 2
Pages: 567-575
DOI
Related Report
Peer Reviewed
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