| Project/Area Number |
22791681
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ビタミンC / 網膜変性 / 加齢性眼疾患 / 酸化ストレス / 遺伝子 |
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| Research Abstract |
(1) In vitamin C knockout mice(SMP30 knockout mice) given the 0.0375 g/L aqueous solution of vitamin C, the eye vitamin C level decreased to approximately 1/3 of that in wild type mice. In vitamin C knockout mice given the 1.5 g/L aqueous solution of vitamin C, the eye vitamin C level was similar to that in wild type mice. Thus, the 2 V vitamin C doses can be viewed as appropriate for achieving V vitamin C deficiency and sufficiency, respectively, in the vitamin C knockout mouse eye.(2) In SMP30 knockout mice(vitamin C deficiency) group retina damage and lens opacities induced by UVR-B were significantly larger than in SMP30 knockout mice(vitamin C sufficiency) group or in wild type mice group. It was suggested that vitamin C deficiency increases retina and lens susceptibility to UVR-B induced oxidative stress in mice.
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