Immunomodulation and neuroprotection in experimental uveoretinitis by regulation of HMGB-1

• Project/Area Number: 22791685
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Kyorin University
• Principal Investigator: WATANABE Takayo 杏林大学, 医学部, 助教 (90458901)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: DAMPs / uveitis / HMGB-1 / DAPMs / ぶどう膜網膜炎

Research Abstract

We investigated whether High Mobility Group Box(HMGB)-1 is expressed and released in ocular tissue and inhibition of HMGB-1 in vivo can suppress ocular inflammation using endotoxin. induced uveitis(EIU). Immunohistochemical study showed higher expression of HMGB-1 in cornea and iris in EIU. induced rats compared to control rats. However, neutralization of HMGB-1 was not able to reduce ocular inflammation in EIU. These results suggest that HMGB-1 may not be involved in the destruction of blood-aqueous barrier in EIU-induced rats.

Research Products

• [Journal Article] Effect of infliximab on gene expression profiling in Behcet's disease (2011)
  • Author(s): Keino H, Watanabe T, Taki W, Okada AA
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 52 Pages: 7681-7686
• [Journal Article] Decreased ocular inflammatory attacks and background retinal and disc vascularleakage in patients with Behcet's disease on infliximab therapy (2011)
  • Author(s): Keino H, Okada AA, Watanabe T, Taki W
  • Journal Title: Br J Ophthalmol Volume: 95 Pages: 1245-1250
• [Journal Article] Interferon-gamma release assay in tuberculous scleritis (2011)
  • Author(s): Taki W, Keino H, Watanabe T, Nakashima C, Okada AA
  • Journal Title: Arch Ophthalmol Volume: 129 Pages: 368-371
• [Journal Article] 急性網膜壊死の治療成績の検討 (2011)
  • Author(s): 渡邊交世, 三木大二郎, 岡田アナベルあやめ, 平形明人
  • Journal Title: 日本眼科学会雑誌 Volume: 115 Pages: 7-12
  • NAID: 10027835136
• [Journal Article] Oral Administration of Retinoic Acid Receptor-α/ss-Specific Ligand Am80 Suppresses Experimental Autoimmune Uveoretinitis (2011)
  • Author(s): Keino H, Watanabe T, Sato Y, Okada, AA
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 115 Pages: 7-12
• [Journal Article] Intravitreal bevacizumab for iris metastasis of small cell lung carcinoma and neovascular glaucoma (2011)
  • Author(s): Nakashima C, Keino H, Watanabe T, Taki W, Okada AA
  • Journal Title: Jpn J Ophthalmol Volume: 55 Pages: 80-81
• [Journal Article] Decreased ocular inflammatory attacks and background retinal and discvascular leakage in patients with Behcet's disease on infliximab therapy (2011)
  • Author(s): Keino H, Okada AA, Watanabe T, Taki W
  • Journal Title: Br J Ophthalmol Volume: 95 Pages: 1245-1250
  • Peer Reviewed
• [Journal Article] Intravitreal bevacizumab for iris metastasis of small-cell lung carcinoma with neovascular glaucoma (2011)
  • Author(s): Nakashima C, Keino H, Watanabe T, et al.
  • Journal Title: Jpn J Ophthalmol Volume: 55 Pages: 80-81
  • NAID: 10029020708
  • Peer Reviewed
• [Journal Article] Oral Administration of Retinoic Acid Receptor-α/β-Specific Ligand Am80 Suppresses Experimental Autoimmune Uveoretinitis. (2011)
  • Author(s): Keino H, Watanabe T, Sato YOkada, AA.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 52 Pages: 1548-1556
  • Peer Reviewed
• [Journal Article] Interferon-γRelease Assay in Tuberculous Scleritis (2011)
  • Author(s): Taki W., Keino H, Watanabe T, Nakashima C, Okada AA
  • Journal Title: Arch Ophthalmol Volume: 129 Pages: 368-71
  • Peer Reviewed
• [Journal Article] Anti-inflammatory effect of retinoic acid on experimental autoimmune uveoretinitis (2010)
  • Author(s): Keino H, Watanabe T, Sato Y, Okada AA
  • Journal Title: Br J Ophthalmol Volume: 94 Pages: 802-807
• [Journal Article] Clinical features and visual outcomes of Japanese patients with scleritis (2010)
  • Author(s): Keino H, Watanabe T, Taki W, Nakashima C, Okada AA
  • Journal Title: Br J Ophthalmol Volume: 94 Pages: 1459-1463
• [Journal Article] Clinical features and visual outcomes of Japanese patients with scleritis. (2010)
  • Author(s): Keino H, Watanabe T, Taki W, Nakashima C, Okada AA.
  • Journal Title: Br J Ophthalmol Volume: 94 Pages: 1459-1463
  • Peer Reviewed
• [Presentation] 角膜内皮細胞減少例における白内障手術 (2012)
  • Author(s): 松木奈央子、渡邊交世、並木泉、二宮夕子、永本敏之
  • Organizer: 第35回日本眼科手術学会
  • Place of Presentation: 京都
• [Presentation] 偽楽屑症候群の白内障手術 (2012)
  • Author(s): 渡邊交世、二宮夕子、並木泉、松木奈央子、永本敏之
  • Organizer: 第35回日本眼科手術学会
  • Place of Presentation: 京都
• [Presentation] 小眼球における白内障手術 (2011)
  • Author(s): 渡邊交世、中野敦雄、二宮夕子、永本敏之
  • Organizer: 第34回日本眼科手術学会
  • Place of Presentation: 京都
  • Year and Date: 2011-01-30
• [Presentation] EDI-OCTを用いた原田病回復期の脈絡膜厚の評価 (2011)
  • Author(s): 慶野博、渡邊交世、中山真紀子、瀧和歌子、岡田アナベルあやめ
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京
• [Presentation] 滲出型加齢黄斑変性に対し初回治療にpegaptanib硝子体内投与を選択した症例の治療成績 (2011)
  • Author(s): 渡邊交世、慶野博、瀧和歌子、越前成旭、岡田アナベルあやめ
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京
• [Presentation] 眼炎症疾患におけるEDI-OCT (2011)
  • Author(s): 岡田アナベルあやめ、中山真紀子、慶野博、渡邊交世、渡邉望、井上真、平形明人
  • Organizer: 第13回Japan Macula Club
  • Place of Presentation: 日蒲郡
• [Presentation] EDI-OCTを用いた片眼性後部強膜炎の脈絡膜厚の評価 (2011)
  • Author(s): 瀧和歌子、慶野博、渡邊交世、伊東真知子、岡田アナベルあやめ
  • Organizer: 第45回日本眼炎症学会
  • Place of Presentation: 京都
• [Presentation] 原田病における脈絡膜厚の長期経過 (2011)
  • Author(s): 中山真紀子、慶野博、渡邊交世、瀧和歌子、岡田アナベルあやめ
  • Organizer: 第45回日本眼炎症学会
  • Place of Presentation: 京都
• [Presentation] Bevacizumab硝子体注射により新生血管の退縮がみられた転移性虹彩腫瘍の1例 (2011)
  • Author(s): 中島史絵、慶野博、渡邊交世、瀧和歌子、岡田アナベルあやめ
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] Enhanced depth imaging optical coherence tomography of the choroid in new-onset acute Vogt-Koyanagi-Harada disease (2011)
  • Author(s): Nakayama M, Keino H, Watanabe T, Inoue M, Hirakata A, Okada AA
  • Place of Presentation: Ft. Lauderdale, Florida, USA
• [Presentation] Vogt-Koyanagi-Harada(VKH)病における脈絡網厚の経時的評価 (2011)
  • Author(s): 中山真紀子, 慶野博, 渡邊交世, 井上真, 平形明人, 岡田アナベルあやめ
  • Organizer: 第64回日本臨床眼科学会
  • Place of Presentation: 神戸
• [Presentation] Enhanced depth imaging optical coherence tomography of the choroid in new-onset acute Vogt-Koyanagi-Harada disease (2011)
  • Author(s): Nakayama M, Keino H, Watanabe T, Inoue M, Hirakata A, Okada AA
  • Organizer: ARVO
  • Place of Presentation: Ft.Lauderdale, Florida, USA
• [Presentation] 眼炎症疾患に伴う黄斑浮腫に対する炭酸脱水素酵素阻害剤内服投与の有効性の再考 (2011)
  • Author(s): 渡辺交世、慶野博、瀧和歌子、越前成旭、岡田アナベルあやめ
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京
• [Presentation] 結核性ぶどう膜炎の合併が疑われた眼内悪性リンパ腫の1例 (2010)
  • Author(s): 渡辺交世、三木大二郎、岡田アナベルあやめ、平形明人
  • Organizer: 第44回日本眼炎症学会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-09
• [Presentation] アトピー性皮膚炎患者における結膜嚢細菌叢 (2010)
  • Author(s): 渡邊交世、中野敦雄、二宮夕子、永本敏之
  • Organizer: 第49回日本白内障学会、第25回日本白内障屈折矯正手術学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-06-25
• [Presentation] サブスペシャリティーサンデー・白内障診療の落とし穴・白内障の形態と症状-視力に影響する混濁はどれ? (2010)
  • Author(s): 渡邊交世
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-15
• [Presentation] 眼結核診断におけるQuantiFERON-TB2Gの有用性についての評価 (2010)
  • Author(s): 渡邊交世、慶野博、中島史絵、瀧和歌子、岡田アナベルあやめ
  • Organizer: 第63回日本臨床眼科学会学術展示優秀賞受賞講演,第114回日本眼科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-15
• [Presentation] 眼結核診断におけるQuantiFERON-TB2Gの有用性についての評価第63回日本臨床眼科学会学術展示優秀賞受賞講演 (2010)
  • Author(s): 渡邊交世、慶野博、中島史絵、瀧和歌子、岡田アナベルあやめ
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-15
• [Presentation] ベーチェット病網膜ぶどう膜炎に対するインフリキシマブ長期投与の有効性 (2010)
  • Author(s): 慶野博, 渡邊交世, 瀧和歌子, 伊東真知子, 岡田アナベルあやめ
  • Organizer: 第64回日本臨床眼科学会
  • Place of Presentation: 神戸
• [Presentation] 結核性ぶどう膜炎の合併が疑われた眼内悪性リンパ種の1例 (2010)
  • Author(s): 渡邊交世, 慶野博, 井上真, 吉野啓, 岡田アナベルあやめ
  • Organizer: 第44回日本眼炎症学会
  • Place of Presentation: 東京
• [Book] 眼科診療クオリファイ8網膜血管障害結核 (2011)
  • Author(s): 渡辺交世
• [Book] 眼科診療クオリファイ8網膜血管障害結核 (2011)
  • Author(s): 渡辺交世
  • Total Pages: 8
  • Publisher: 中山書店