Immunomodulation and neuroprotection in experimental uveoretinitis by regulation of HMGB-1
| Project/Area Number |
22791685
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | DAMPs / uveitis / HMGB-1 / DAPMs / ぶどう膜網膜炎 |
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| Research Abstract |
We investigated whether High Mobility Group Box(HMGB)-1 is expressed and released in ocular tissue and inhibition of HMGB-1 in vivo can suppress ocular inflammation using endotoxin. induced uveitis(EIU). Immunohistochemical study showed higher expression of HMGB-1 in cornea and iris in EIU. induced rats compared to control rats. However, neutralization of HMGB-1 was not able to reduce ocular inflammation in EIU. These results suggest that HMGB-1 may not be involved in the destruction of blood-aqueous barrier in EIU-induced rats.
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Report
(3 results)
Research Products
(35 results)
