| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Resveratrol is known as one of antioxidant polyphenols. The purpose of the present study was to investigate the effect of resveratrol on the diabetic retina. The diabetic model mice were orally treated with resveratrol for seven days. Administration of resveratrol significantly reduced leukocyte adhesion to the retinal vessels of diabetic mice. In addition, the diabetic animals treated with resveratrol showed a significant decrease in retinal inflammatory molecules, which were upregulated following the induction of diabetes. The current data suggest the potential use of resveratrol as a therapeutic agent for diabetic retinopathy.
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