Effect of hydrogen gas in the age-related macular degeneration

• Project/Area Number: 22791688
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Keio University
• Principal Investigator: KOTO Takashi 慶應義塾大学, 医学部, 助教 (60464814)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 加齢黄斑変性 / 酸化ストレス / 水素ガス / 網膜色素上皮細胞 / 脈絡膜新生血管

Research Abstract

Age-related macular degeneration(AMD) is one of the leading causes of blindness in the aged population. The choroidal neovascularization and the related exudative changes are the main findings of AMD. It has been believed to be caused by oxidative stress, however, there was no established preventive therapies. In this study, we explored the possibility to use hydrogen gas to suppress oxidative stress in the retina, using an animal model.

Research Products

• [Journal Article] The Vision Van, a Mobile Eye Clinic, Aids Relief Efforts in Tsunami-stricken Areas (2012)
  • Author(s): Oshima CR, Yuki K, Uchida A, Dogru M, Koto T, Ozawa Y, Tsubota K
  • Journal Title: Keio J Med Volume: 61 Pages: 10-14
  • NAID: 10030164611
  • Peer Reviewed
• [Journal Article] Use of micronutrient supplement for preventing advanced age-related macular degeneration in Japan (2012)
  • Author(s): Sasaki M, Shinoda H, Koto T, Uchida A, Tsubota K, Ozawa Y
  • Journal Title: Arch Ophthalmol Volume: 130 Pages: 254-255
  • Peer Reviewed
• [Journal Article] Clinical findings in a choroideremia patient who underwent vitrectomy for retinal detachment associated with macular hole (2011)
  • Author(s): Shinoda H, Koto T, Fujiki K, Murakami A, Tsubota K, Ozawa Y
  • Journal Title: Jpn J Ophthalmol Volume: 55 Pages: 169-171
  • NAID: 10029021013
  • Peer Reviewed
• [Journal Article] Calcium channel blocker nilvadipine, but not diltiazem, inhibits ocular inflammation in endotoxin-induced uveitis (2010)
  • Author(s): Ishida S, Koto T, Nagai N, Oike Y
  • Journal Title: Jpn J Ophthalmol Volume: 54 Pages: 594-601
  • NAID: 10027666392
  • Peer Reviewed
• [Journal Article] Retinal aging and sirtuins (2010)
  • Author(s): Ozawa Y, Kubota S, Narimatsu T, Yuki K, Koto T, Sasaki M, Tsubota K
  • Journal Title: Ophthalmic Res Volume: 14 Pages: 199-203
  • Peer Reviewed
• [Presentation] 内境界膜剥離併用硝子体手術で中心窩網膜分離が改善したX染色体性若年性網膜分離の1例 (2011)
  • Author(s): 川島弘彦, 篠田肇, 持丸博史, 内田敦郎, 厚東隆志, 永井紀博, 小沢洋子, 坪田一男
  • Organizer: 第50回日本網膜硝子体学会総会
  • Place of Presentation: 東京
• [Presentation] 視力1. 0以上の網膜上膜に対する実用視力測定の有効性 (2011)
  • Author(s): 西恭代, 篠田肇, 結城賢弥, 内田敦郎, 厚東隆志, 小沢洋子, 坪田一男
  • Organizer: 第34回日本眼科手術学会総会
  • Place of Presentation: 東京
• [Presentation] 内境界膜剥離併用硝子体手術で中心窩網膜分離が改善したX染色体性若年性網膜分離の1例 (2011)
  • Author(s): 川島弘彦、厚東隆志, ら
  • Organizer: 第50回日本網膜硝子体学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
• [Book] 眼に良い食べ物 (2010)
  • Author(s): 厚東隆志
  • Publisher: メディカル葵出版