The evaluation of the ocular surface for the severe dry eye

• Project/Area Number: 22791690
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Keio University
• Principal Investigator: SAIJO Yumiko 慶應義塾大学, 医学部, 研究員 (80407105)
• Research Collaborator: OGAWA Yoko 慶應義塾大学, 医学部, 特任准教授 (30160774)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ドライアイ / マイボーム腺 / 重症ドライアイ / 免疫抑制剤治療 / 炎症 / 眼表面評価

Research Abstract

Chronic graft-versus-host(cGVHD) disease is one of the cause of the severe dry eye. We evaluated the morphological changes of the meibomian glands(MGs) using non-contact infrared meibography, confocal microscopy and fluorescein/Rose-bengal staining in dry eye patients with cGVHD.

Research Products

• [Journal Article] Morphological evaluation of meibomian glands using noncontact infrared meibography (2013)
  • Author(s): Ban Y, Shimazaki-Den S, Tsubota K, Shimazaki J.
  • Journal Title: Ocular Surf Volume: 11 Pages: 47-53
  • Peer Reviewed
• [Journal Article] Surgical management of lacrimal punctal cauterization in chronic GVHD-related dry eye with recurrent punctal plug extrusion (2012)
  • Author(s): Yaguchi S, Ogawa Y, Kamoi M, Uchino M, Tatematsu Y, Ban Y, Ohba E, Okamoto S, Goto E, Tsubota K.
  • Journal Title: Bone Marrow Transplant Volume: 47 Pages: 1465-1469
  • Peer Reviewed
• [Journal Article] Morphologic evaluation of meibomian glands in chronic graft-versus-host disease using in vivo laser confocal microscopy (2011)
  • Author(s): Ban Y, Ogawa Y, Ibrahim OM, Tatematsu Y, Kamoi M, Uchino M, Yaguchi S, DogruM, Tsubota K.
  • Journal Title: Mol Vis. Volume: 17 Pages: 2533-2543
  • Peer Reviewed
• [Journal Article] Surgical Management of Severe Canaliculitis Due to Intracanalicular Plug Migration Using Fish-Hook-Type Retractors : A Report of Two Patients (2011)
  • Author(s): Ban Y, Ideta S, Dogru M, Ogawa Y, Goto E, Shimazaki J.
  • Journal Title: Jpn J Ophthalmol Volume: 55 Pages: 68-70
  • NAID: 10029020671
  • Peer Reviewed
• [Journal Article] Morphologic evaluation of meibomian glands in chronic graft-versus-host disease using in vivo laser confocal microscopy (2011)
  • Author(s): Yumiko Ban, Yoko Ogawa, et al
  • Journal Title: Molecular Vision Volume: 17 Pages: 2533-2543
  • Peer Reviewed
• [Journal Article] Surgical Management of Severe Canaliculitis Due to Intracanalicular Plug Migration Using Fish-Hook-Type Retractors : A Report of Two Patients (2011)
  • Author(s): Yumiko Ban, Shinji Ideta, Murat Dogru, et al.
  • Journal Title: Japanese Journal of Ophthalmology Volume: 55 Pages: 67-85
  • Peer Reviewed
• [Presentation] 生体共焦点顕微鏡による眼慢性GVHD症例のマイボーム腺の観察 (2013)
  • Author(s): 番裕美子, 小川葉子, オサマイブラヒム, 立松由佳子, 鴨居瑞加, 内野美樹, 谷口紗織, 村戸ドール, 坪田一男
  • Organizer: 第7回箱根ドライアイクラブ
  • Year and Date: 2013-05-31
• [Presentation] 3つの診断基準のよるシェーグレン症候群の眼科的立場からの比較検討 (2012)
  • Author(s): 番裕美子, 小川葉子, 谷口紗織, 内野美樹, 鴨居瑞加, 角田和之, 坪井洋人, 住田孝之, 竹内勤, 坪田一男
  • Organizer: 角膜カンファランス 2012
  • Place of Presentation: 東京
  • Year and Date: 2012-02-23
• [Presentation] 3つの診断基準によるシェーグレン症候群診断の眼科的立場からの比較検討 (2012)
  • Author(s): 番裕美子、小川葉子, 他
  • Organizer: 角膜カンファランス2012
  • Place of Presentation: ホテルニューオータニ(東京都)
  • Year and Date: 2012-02-23
• [Presentation] 生体共焦点顕微鏡による眼慢性 GVHD 症例のマイボーム腺の観察 (2011)
  • Author(s): 番裕美子, 小川葉子, イブラヒムオサマ, 立松由佳子, 鴨居瑞加, 内野美樹, 谷口紗織, 村戸ドール, 坪田一男
  • Organizer: 角膜カンファランス2011
  • Place of Presentation: 品川プリンスホテル・東京
  • Year and Date: 2011-02-17
• [Presentation] 生体共焦点顕微鏡による眼慢性GVHD症例のマイボーム腺の観察 (2011)
  • Author(s): 番裕美子、小川葉子、イブラヒムオサマ, 他
  • Organizer: 角膜カンファランス2011
  • Place of Presentation: 品川プリンスホテル、東京
  • Year and Date: 2011-02-17
• [Presentation] Characterization o fmeibomian gland in patients with chronic graft-versus-host disease related dry eye using in vivo laser confocal microscopy (2010)
  • Author(s): Ban Y, Ogawa Y, Ibrahim OM, Tatematsu Y, Dogru M, Tsubota K
  • Organizer: The 2nd Asia Cornea Society Biennial Scientific Meeting
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-12-03
• [Presentation] Lacrimal punctual cauterization in the management of ocular graft-versus-host disease (2010)
  • Author(s): Yaguchi S, Ogawa Y, Kamoi M, Uchino M, Tatematsu Y, Ban Y, Ohba E, Goto E, Tsubota K
  • Organizer: The 2nd Asia Cornea Society Biennial Scientific Meeting
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-12-03
• [Presentation] Characterization of Meibomian Gland with Chronic Graft-Versus-Host Disease Related Dry Eye Using In Vivo Laser Confocal Microscopy (2010)
  • Author(s): Yumiko Ban, Yoko Ogawa, Osama M.A.Ibrahim, et al.
  • Organizer: The 2^<nd> Asia Cornea Society Biennial Scientific Meeting
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-12-02
• [Presentation] Morphologic Evaluation of Meibomian Glands in Chronic Graft-Versus-Host Disease Using In Vivo Laser Confocal Microscopy (2010)
  • Author(s): Yumiko Ban, Yoko Ogawa, Osama M.A.Ibrahim, et al.
  • Organizer: 6^<th> International Conference on the Tear Film & Ocular Surface and Clinical Relevance
  • Place of Presentation: Florence, Italy
  • Year and Date: 2010-09-25
• [Presentation] Morphologic evaluation of meibomian gland in chronic graft-versus-host disease (2010)
  • Author(s): Ban Y, Ogawa Y, Ibrahim OM, Tatematsu Y, Dogru M, Tsubota K
  • Organizer: 6th International Conference on the Tear Film & Ocular Surface : Basic Science and Clinical relevance
  • Place of Presentation: Florence, Italy
  • Year and Date: 2010-09-22
• [Presentation] Morphologic Evaluation of Meibomian Glands Using Noncontact Infrared Meibography (2010)
  • Author(s): Ban Y, Den S, Shimazaki J, Tsubota K
  • Organizer: World Cornea CongressIV
  • Place of Presentation: Boston, USA
  • Year and Date: 2010-04-07
• [Presentation] 生体共焦点顕微鏡による眼慢性GVHD症例のマイボーム腺の観察
  • Author(s): 西條裕美子、小川葉子、オサマイブラヒム、立松由佳子、鴨居瑞加、内野美樹、谷口紗織、村戸ドール、坪田一男
  • Organizer: 第7回 箱根ドライアイクラブ
  • Place of Presentation: 小田原
• [Book] ドライアイスペシャリストへの道 (2013)
  • Author(s): 西條裕美子
  • Publisher: 中山書店
• [Book] メディカルレビュー社基本手技シリーズ シルマーテスト (2011)
  • Author(s): 番裕美子
  • Publisher: Frontiers in Dry Eye