Research Project
Grant-in-Aid for Young Scientists (B)
We demonstrated that tear volume significantly decreased in metabolic syndrome model mice fed with a high fat diet. Inflammatory cell infiltration and inflammatory related gene expression level in the lacrimal glands were significantly increased in the high fat fed group. Immunohistochemistry of the lacrimal glands showed positive staining for 8-OHdG in the high fat group. Metabolic syndrome influences lacrimal gland function in mice, which might be caused by oxidative damage and the subsequent gland inflammation.
All 2011
All Presentation (2 results)
