Research Project
Grant-in-Aid for Young Scientists (B)
Tet-mev-1 mice revealed decreased tear production with the morphological changes. Tear quantity values in Tet-mev-1 mice were lower compared to the wild type mice. The lacrimal gland of Tet-mev-1 mice overproduced superoxide anion(O & _2^-) and oxidative protein compared to the wild type mice. Histopathological analyses showed the hallmarks of lacrimal gland inflammation by presence of intense mononuclear leukocytic infiltration and fibrosis around acinar cell staining by 8-OHdG antibody in the lacrimal gland of Tet-mev-1 mice. These findings strongly suggest that oxidative stress can be a causative factor for the development of dry eye disease.
All 2011 2010
All Presentation (10 results)