• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Search for the mechanism of dry eye disease using active oxygen excessive model mouse

Research Project

Project/Area Number 22791692
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionKeio University

Principal Investigator

UCHINO Yuichi  慶應義塾大学, 医学部, 特任助教(非常勤) (80365337)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords活性酸素 / ドライアイ / 酸化傷害 / ミトコンドリア / 涙腺 / 炎症 / 分泌減少
Research Abstract

Tet-mev-1 mice revealed decreased tear production with the morphological changes. Tear quantity values in Tet-mev-1 mice were lower compared to the wild type mice. The lacrimal gland of Tet-mev-1 mice overproduced superoxide anion(O & _2^-) and oxidative protein compared to the wild type mice. Histopathological analyses showed the hallmarks of lacrimal gland inflammation by presence of intense mononuclear leukocytic infiltration and fibrosis around acinar cell staining by 8-OHdG antibody in the lacrimal gland of Tet-mev-1 mice. These findings strongly suggest that oxidative stress can be a causative factor for the development of dry eye disease.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (10 results)

All 2011 2010

All Presentation (10 results)

  • [Presentation] A new mouse model of dry eye disease <Oxidative stress affect functional decline in lacrimal gland>2011

    • Author(s)
      内野裕一
    • Organizer
      Kyoto Cornea Club
    • Place of Presentation
      ウェスチン都ホテル(京都府)
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] ミトコンドリアとドライアイ2011

    • Author(s)
      内野裕一、川北哲也、宮沢正樹、尾内宏美、安田佳代、石井恭正、小川葉子、榛村重人、石井直明、坪田一男
    • Organizer
      第16回シェーグレン症候群セミナー
    • Place of Presentation
      東京
    • Year and Date
      2011-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] ミトコンドリアとドライアイ2011

    • Author(s)
      内野裕一
    • Organizer
      第16回シェーグレン症候群セミナー
    • Place of Presentation
      HAKUYOHビル(東京都)(招待講演)
    • Year and Date
      2011-06-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] New model mouse of dry eye disease : Oxidative Stress Affect Functional Decline In Lacrimal Gland2011

    • Author(s)
      Yuichi Uchino
    • Place of Presentation
      Kyoto Cornea Club,京都
    • Related Report
      2011 Final Research Report
  • [Presentation] The role of intracellular oxidative stress in the mechanism of the dry eye disease2011

    • Author(s)
      Yuichi Uchino, Tetsuya Kawakita, Masaki Miyazawa, Takamasa Ishii, Hiromi Onouchi, Kayo Yasuda, Yoko Ogawa, Shigeto Shimmura, Naoaki Ishii, Kazuo Tsubota
    • Organizer
      Association for Research in Vision and Ophthalmology(ARVO)
    • Place of Presentation
      Fort Lauderdale
    • Related Report
      2011 Final Research Report
  • [Presentation] Tet-mev-1マウスを用いた細胞内酸化ストレスによるドライアイ発症メカニズムの解析2011

    • Author(s)
      内野裕一、川北哲也、宮沢正樹、尾内宏美、安田佳代、石井恭正、小川葉子、榛村重人、石井直明、坪田一男
    • Organizer
      第35回角膜カンファランス
    • Place of Presentation
      品川
    • Related Report
      2011 Final Research Report
  • [Presentation] The role of intracellular oxidative stress in the mechanism of the dry eye disease2011

    • Author(s)
      内野裕一
    • Organizer
      Association for Research in Vision and Ophthalmology (ARVO) 2011
    • Place of Presentation
      Fort Lauderdale, US
    • Related Report
      2011 Annual Research Report
  • [Presentation] Tet-mev-1マウスを用いた細胞内酸化ストレスによるドライアイ発症メカニズムの解析2011

    • Author(s)
      内野裕一
    • Organizer
      角膜カンファランス2011
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] A New Mouse Model of Dry Eye Disease(Tet-mev-1 Mice): Oxidative Stress Affect Functional Decline in Lacrimal Gland2010

    • Author(s)
      Yuichi Uchino, Tetsuya Kawakita, Masaki. Miyazawa, Takamasa Ishii, Hiromi Onouchi, Kayo Yasuda, Shigeto Shimmura, Naoaki Ishii, Kazuo Tsubota
    • Organizer
      The 6th International Conference on the Tear Film & Ocular Surface
    • Place of Presentation
      Florence, Italy
    • Related Report
      2011 Final Research Report
  • [Presentation] A NEW MOUSE MODEL OF DRY EYE DISEASE (Tet-mev-1 Mice) : OXIDATIVE STRESS AFFECT FUNCTIONAL DECLINE IN LACRIMAL GLAND.2010

    • Author(s)
      内野裕一
    • Organizer
      The 6th International Conference on the Tear Film & Ocular Surface
    • Place of Presentation
      Florence, Italy
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi