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Meibomian Gland(MG) and Ocular Surface Alterations in Sod1 knock-out(KO) Mice : A Novel Model for Age Related Dry Eye Disease.

Research Project

Project/Area Number 22791694
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionKeio University

Principal Investigator

IBRAHIM Osama mohamed aly  慶應義塾大学, 医学部, 研究員(非常勤) (90528340)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsマイボーム腺 / ドライアイ / 酸化ストレス
Research Abstract

We investigated the alterations of the MG in the SOD1KO mice. SOD1KO caused inflammation, apoptosis, dry eye and corneal damage. The SOD1-KO mouse appears to be a promising model for the study of age related meibomian gland alterations.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (3 results)

All 2011 2010

All Presentation (3 results)

  • [Presentation] Evidence For Accelerated Apoptosis And Altered Meibomian Glandular Differentiation In The Sod1 Knock-out Mice Novel Model For Age Related Dry Eye Disease2011

    • Author(s)
      Ibrahim Osama
    • Organizer
      The Association for Research in Vision and Ophthalmology(ARVO)
    • Place of Presentation
      Lauderdale, USA
    • Year and Date
      2011-05-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Evidence For Accelerated Apoptosis And Altered Meibomian Glandular Differentiation In The Sod1 Knock-out Mice Novel Model For Age Related Dry Eye Disease2011

    • Author(s)
      Osama Ibrahim
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO)
    • Place of Presentation
      フロリダ州フォートローダーデール(米国)
    • Year and Date
      2011-05-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Meibomian Gland and Ocular Surface Alterations in Sod1 knock-out Mice : A Novel Model for Age Related Dry Eye Disease.2010

    • Author(s)
      Osama Ibrahim
    • Organizer
      ARVO
    • Place of Presentation
      U.S.A., Fort Lauderdale
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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