Immunological approach to investigate the mechanism of treatment resistant endogenous uveitis and to establish a new treatment

• Project/Area Number: 22791696
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Tokyo Medical University
• Principal Investigator: OKUNUKI Yoko 東京医科大学, 医学部, 助教 (40459508)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: Vogt-小柳-原田病 / IL-17 / トランスレーショナルリサーチ / 副腎皮質ステロイド / 末梢血リンパ球(PBMC) / 免疫学

Research Abstract

In Vogt-Koyanagi-Harada disease, patients with high IL-17 production from concanavalin A stimulated PBMC were older, took longer time to improve visual acuity, and needed greater amount of corticosteroid than patients with low IL-17.Prognosis of the patients with high IL-17 production with PBMC was suggested to be worse than the patients with low IL-17.IL-17 production from PBMC can be a disease activity marker in Vogt-Koyanagi-Harada disease.

Research Products

• [Journal Article] Costimulatory molecule expression on human uveal melanoma cells : functional analysis of CD40 and B7-H1 (2012)
  • Author(s): Ma J, Usui Y, Kezuka T, Okunuki Y, Zhang L, An X, Mizota, Goto H
  • Journal Title: Experimental Eye Research Volume: 96 Issue: 1 Pages: 98-106
  • DOI: 10.1016/j.exer.2011.12.014
  • Peer Reviewed
• [Journal Article] Relation of intraocular concentrations of inflammatory factors and improvement of macular edema after vitrectomy in branch retinal vein occlusion (2011)
  • Author(s): Okunuki Y, Usui Y, Katai N, Kezuka T, Takeuchi M, Goto H, Wakabayashi Y
  • Journal Title: American Journal of Ophthalmology Volume: 151 Pages: 610-616
  • Peer Reviewed
• [Journal Article] Four cases of bilateral acute retinal necrosis with a long interval after the initial onset (2011)
  • Author(s): Okunuki Y, Usui Y, Kezuka T, Takeuchi M, Goto H
  • Journal Title: British Journal of Ophthalmology Volume: 95 Pages: 1251-1254
  • Peer Reviewed
• [Journal Article] Increases of vitreous monocyte chemotactic protein 1 and interleukin 8 levels in patients with concurrent hypertension and diabetic retinopathy (2011)
  • Author(s): Wakabayashi Y, Usui Y, Okunuki Y, Kezuka T, Takeuchi M, Iwasaki T, Ohno A, Goto H
  • Journal Title: Retina Volume: 31 Pages: 1951-7
  • Peer Reviewed
• [Journal Article] Increases of vitreous monocyte chemotactic protein 1 and interleukin 8 levels in patients with concurrent hypertension and diabetic retinopathy (2011)
  • Author(s): Okunuki Y, Wakabayashi Y, Usui Y, Kezuka T, Takeuchi M, Iwasaki T, Ohno A, Goto H
  • Journal Title: Retina Volume: 31 Issue: 9 Pages: 1951-1957
  • DOI: 10.1097/iae.0b013e31820d3cee
  • Peer Reviewed
• [Journal Article] Relation of intraocular concentrations of inflammatory factors and improvement of macular edema after vitrectomy in branch retinal vein occlusion. (2011)
  • Author(s): Okunuki Y, Usui Y, Katai N, Kezuka T, Takeuchi M, Goto H, Wakabayashi Y.
  • Journal Title: American Journal of Ophthalmology Volume: 151 Pages: 610-616
  • Peer Reviewed
• [Journal Article] Four cases of bilateral acute retinal necrosis with a long interval after the initial onset. (2011)
  • Author(s): Okunuki Y, Usui Y, Kezuka T, Takeuchi M, Goto H.
  • Journal Title: British Journal of Ophthalmology Volume: (ePub ahead of print)
  • Peer Reviewed
• [Journal Article] Correlation of vascular endothelial growth factor with chemokines in the vitreous in diabetic retinopathy (2010)
  • Author(s): Wakabayashi Y, Usui Y, Okunuki Y, Kezuka T, Takeuchi M, Goto H, Iwasaki T
  • Journal Title: Retina Volume: 30 Pages: 339-44
  • Peer Reviewed
• [Presentation] Vogt-小柳-原田病の発症時年齢および性別と臨床像に関する検討 (2012)
  • Author(s): 奥貫陽子、臼井嘉彦、毛塚剛司、後藤浩
  • Organizer: 116回日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] Cytokine analysis and visual prognosis of Vogt-Koyanagi-Harada disease (2011)
  • Author(s): Yoko Okunuki
  • Organizer: The 11th international ocular inflammation society congress and international assembly of ocular inflammation society
  • Place of Presentation: インド
• [Presentation] Cytokine analysis and visual prognosis of Vogt-Koyanagi-Harada disease (2011)
  • Author(s): 奥貫陽子
  • Organizer: The 11^<th> international ocular inflammation society congress and international assembly of ocular inflammation society
  • Place of Presentation: インド、ゴア
• [Presentation] Cytokine analysis to estimate the disease activity (2010)
  • Author(s): Yoko Okunuki, Yoshihiko Usui, Takeshi Kezuka, Masaru Takeuchi, Hiroshi Goto
  • Organizer: Vogt-Koyanagi-Harada disease patients ARVO2010
  • Place of Presentation: フロリダ
• [Presentation] Vogt-小柳-原田病患者の末梢血単核球IL-17産生とステロイド治療に対する反応の検討 (2010)
  • Author(s): 奥貫陽子、臼井嘉彦、毛塚剛司、竹内大、後藤浩
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋
• [Presentation] Cytokine analysis to estimate the disease activity in Vogt-Koyanagi-Harada disease patients (2010)
  • Author(s): Yoko Okunuki, Yoshihiko Usui, Takeshi Kezuka, Masaru Takeuchi, Hiroshi Goto
  • Organizer: ARVO 2010
  • Place of Presentation: アメリカ、フロリダ州