Phenotypic difference of age-related macular degeneration as determined by single nucleotide polymorphisms
Project/Area Number |
22791706
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Ophthalmology
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Research Institution | Kyoto University (2011) Foundation for Biomedical Research and Innovation (2010) |
Principal Investigator |
OISHI Akio 京都大学, 医学研究科, 助教 (50572955)
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 遺伝学 / イメージング |
Research Abstract |
We explored single nucleotide polymorphisms(SNPs), which are associated with development, prognosis, or response to treatment of age-related macular degeneration. We found that 1) SERPINF1 SNPs influence the response to and visual prognosis after photodynamic therapy 2) SERPING1 SNPs have little influence on the development of AMD in Japanese 3) C2/CFB SNPs have protective effect in the risk of developing AMD. In addition, we published several reports concerning the association between optical coherence tomography findings and visual function.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population2012
Author(s)
Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Akagi-Kurashige Y, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 53
Issue: 2
Pages: 794-798
DOI
Related Report
Peer Reviewed
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[Journal Article] Association between the SERPING1 gene and age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese2011
Author(s)
Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N
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Journal Title
PLoS One
Volume: 6
Issue: 4
Pages: e19108-e19108
DOI
Related Report
Peer Reviewed
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[Journal Article] Genetic variants in pigment epithelium-derived factor influence response of polypoidal choroidal vasculopathy to photodynamic therapy2011
Author(s)
Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Ooto S, Tamura H, Saito M, Saito K, Iida T, Oishi A, Kurimoto Y, Matsuda F, Yoshimura N
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Journal Title
Ophthalmology
Volume: 118
Issue: 7
Pages: 1408-15
DOI
Related Report
Peer Reviewed
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