Phenotypic difference of age-related macular degeneration as determined by single nucleotide polymorphisms

• Project/Area Number: 22791706
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Kyoto University (2011); Foundation for Biomedical Research and Innovation (2010)
• Principal Investigator: OISHI Akio 京都大学, 医学研究科, 助教 (50572955)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 遺伝学 / イメージング

Research Abstract

We explored single nucleotide polymorphisms(SNPs), which are associated with development, prognosis, or response to treatment of age-related macular degeneration. We found that 1) SERPINF1 SNPs influence the response to and visual prognosis after photodynamic therapy 2) SERPING1 SNPs have little influence on the development of AMD in Japanese 3) C2/CFB SNPs have protective effect in the risk of developing AMD. In addition, we published several reports concerning the association between optical coherence tomography findings and visual function.

Research Products

• [Journal Article] Long-term effect of intravitreal injection of anti-VEGF agent for visual acuity and chorioretinal atrophy progression in myopic choroidal neovascularization (2013)
  • Author(s): Oishi A, Yamashiro K, Tsujikawa A, Ooto S, Tamura H, Nakata I, Miyake M, Yoshimura N
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 251 Issue: 1 Pages: 1-7
  • DOI: 10.1007/s00417-012-2022-8
  • NAID: 120005241384
  • Peer Reviewed
• [Journal Article] Recovery of photoreceptor outer segments after anti-VEGF therapy for age-related macular degeneration (2012)
  • Author(s): Oishi A, Shimozono M, Mandai M, Hata M, Nishida A, Kurimoto Y
  • Journal Title: Graefes Arch Clin Exp Ophthalmol 2012 in press Volume: 251 Issue: 2 Pages: 435-440
  • DOI: 10.1007/s00417-012-2034-4
  • NAID: 120005474470
  • Year and Date: 2012-05-12
  • Peer Reviewed
• [Journal Article] Relationship between retinal morphological findings and visual function in age-related macular degeneration (2012)
  • Author(s): Akagi-Kurashige Y, Tsujikawa A, Oishi A, Ooto S, Yamashiro K, Tamura H, Nakata I, Ueda-Arakawa N, Yoshimura N
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: (in press) Issue: 8 Pages: 68-80
  • DOI: 10.1007/s00417-012-1928-5
  • NAID: 120004873995
  • Peer Reviewed
• [Journal Article] Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population (2012)
  • Author(s): Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Akagi-Kurashige Y, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 53 Issue: 2 Pages: 794-798
  • DOI: 10.1167/iovs.11-8468
  • Peer Reviewed
• [Journal Article] The significance of cone outer segment tipas as a prognostic factor in epiretinal membrane surgery (2012)
  • Author(s): Shimozono M, Oishi A, Hata M, Matsuki T, Ito S, Ishida K, Kurimoto Y
  • Journal Title: Am J Ophthalmol Volume: 153 Issue: 4 Pages: 698-704
  • DOI: 10.1016/j.ajo.2011.09.011
  • Peer Reviewed
• [Journal Article] Possible vitreous involvement in a case with rapidly progressing choroidal neovascularization (2012)
  • Author(s): Hata M, Oishi A, Mandai M, Kurimoto Y
  • Journal Title: Indian J Ophthalmol Volume: 60 Issue: 1 Pages: 57-58
  • DOI: 10.4103/0301-4738.91348
  • Peer Reviewed
• [Journal Article] Recovery of photoreceptor outer segments after anti-VEGF therapy for age-related macular degeneration (2012)
  • Author(s): Oishi A, Shimozono M, Hata M, Mandai M, Nishida A, Kurimoto Y
  • Journal Title: Graefe's Archives of Ophthalmology Volume: (In press)
  • NAID: 120005474470
  • Peer Reviewed
• [Journal Article] Bilateral Nonarteritic Anterior Ischemic Optic Neuropathy Following Intravitreal Injection of Pegaptanib (2011)
  • Author(s): Kimakura M, Oishi A, Mandai M, Kurimoto Y
  • Journal Title: J Clinic Experiment Ophthalmol Volume: 2 Issue: 06 Pages: 162-162
  • DOI: 10.4172/2155-9570.1000162
  • Peer Reviewed
• [Journal Article] Remission and dropout rate of anti-VEGF therapy for age-related macular degeneration (2011)
  • Author(s): Oishi A, Mandai M, Nishida A, Hata M, Matsuki T, Kurimoto Y
  • Journal Title: Eur J Ophthalmol Volume: 21 Pages: 777-82
  • Peer Reviewed
• [Journal Article] Characteristics of fine vascular network pattern before photodynamic therapy associated with recurrence of polypoidal choroidal vasculopathy (2011)
  • Author(s): Oishi A, Mandai M, Kimakura M, Nishida A, Kurimoto Y
  • Journal Title: Eye(Lond) Volume: 25 Issue: 8 Pages: 1020-6
  • DOI: 10.1038/eye.2011.110
  • Peer Reviewed
• [Journal Article] Restoration of the photoreceptor outer segment and visual outcomes after macular hole closure : spectral-domain optical coherence tomography analysis (2011)
  • Author(s): Shimozono M, Oishi A, Hata M, Kurimoto Y
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 249 Issue: 10 Pages: 1469-76
  • DOI: 10.1007/s00417-011-1681-1
  • Peer Reviewed
• [Journal Article] Association between the SERPING1 gene and age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese (2011)
  • Author(s): Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N
  • Journal Title: PLoS One Volume: 6 Issue: 4 Pages: e19108-e19108
  • DOI: 10.1371/journal.pone.0019108
  • Peer Reviewed
• [Journal Article] Genetic variants in pigment epithelium-derived factor influence response of polypoidal choroidal vasculopathy to photodynamic therapy (2011)
  • Author(s): Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Ooto S, Tamura H, Saito M, Saito K, Iida T, Oishi A, Kurimoto Y, Matsuda F, Yoshimura N
  • Journal Title: Ophthalmology Volume: 118 Issue: 7 Pages: 1408-15
  • DOI: 10.1016/j.ophtha.2010.12.011
  • Peer Reviewed
• [Journal Article] Remission and dropout rate of anti-VEGF therapy for age-related macular degeneration. (2011)
  • Author(s): Akio Oishi, Michiko Mandai, Akihiro Nishida, et al.
  • Journal Title: European Journal of Ophthalmology Volume: (In press)
  • Peer Reviewed
• [Journal Article] Characteristics of fine vascular network pattern before photodynamic therapy associated with recurrence of polypoidal choroidal vasculopathy (2011)
  • Author(s): Akio Oishi, Michiko Mandai, Mikiko Kimakura, et al.
  • Journal Title: Eye Volume: (In press)
  • Peer Reviewed
• [Journal Article] SERPING1 Variants and Neovascular Age-1 Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in a Japanese Population (2011)
  • Author(s): Isao Nakata, Kenji Yamashiro, Ryo Yamada, Norimoto Gotoh, Hideo Nakanishi, et al.
  • Journal Title: Plos One Volume: 6
  • Peer Reviewed
• [Presentation] Retinal structure plasticity after anti-VEGF therapy for age-related macular degeneration (2011)
  • Author(s): Oishi A, Shimozono M, Mandai M, Hata M, Nishida A, Kurimoto Y
  • Organizer: American Academy of Ophthalmology
  • Place of Presentation: Orlando, FL
• [Presentation] The remission rate of anti-VEGF therapy for choroidal neovascularization (2010)
  • Author(s): Akio Oishi, Michiko Mandai, Akihiro Nishida, et al.
  • Organizer: 第27回 日本眼循環学会(English session)
  • Place of Presentation: ポートピアホテル(神戸市)
  • Year and Date: 2010-07-30
• [Presentation] The remission rate of anti-VEGF therapy for choroidal neovascularization (2010)
  • Author(s): Oishi A, Mandai M, Nishida A, Hata M, Matsuki T, Kurimoto Y
  • Organizer: 第27回日本眼循環学会(English session)
  • Place of Presentation: 神戸市
• [Book] 実践診断に役立つOCT画像撮りかた講座 (2011)
  • Author(s): 吉村長久監修大石明生編集
  • Publisher: 株式会社メディカ出版