Investigation of the molecular-target therapy against child cancers by using the Hedgehog signal inhibitor
| Project/Area Number |
22791708
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatric surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 小児腫瘍 / ヘッジホッグ / Gli1 / 横紋筋肉腫 / 分子標的治療 / Hedgehog(Hh) / Forskolin / 神経芽腫 / 肝芽腫 / Hedgehog (Hh) / 抑制剤 / 治療標的 |
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| Research Abstract |
The mutation of Hedgehog (Hh) signal is associated with the proliferation or the carcinogenesis of several adult cancers, but little is known about child cancers. We investigated the antitumor effect of the Gli1 inhibitor Forskolin against child cancer cells, focusing on Hh signal pathway as a therapeutic target.
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Report
(4 results)
Research Products
(10 results)
