Investigation of the molecular-target therapy against child cancers by using the Hedgehog signal inhibitor

• Project/Area Number: 22791708
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatric surgery
• Research Institution: Osaka University
• Principal Investigator: NOMURA Motonari 大阪大学, 医学部附属病院, 医員 (40546909)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 小児腫瘍 / ヘッジホッグ / Gli1 / 横紋筋肉腫 / 分子標的治療 / Hedgehog(Hh) / Forskolin / 神経芽腫 / 肝芽腫 / Hedgehog (Hh) / 抑制剤 / 治療標的

Research Abstract

The mutation of Hedgehog (Hh) signal is associated with the proliferation or the carcinogenesis of several adult cancers, but little is known about child cancers. We investigated the antitumor effect of the Gli1 inhibitor Forskolin against child cancer cells, focusing on Hh signal pathway as a therapeutic target.

Research Products

• [Journal Article] 13-Cis retinoic acid can enhance the antitumor activity of non-replicating Sendai virus particle against neuroblastoma (2013)
  • Author(s): Motonari Nomura
  • Journal Title: Cancer Science Volume: 104巻 Pages: 238-244
  • Peer Reviewed
• [Journal Article] 13-Cis retinoic acid can enhance the antitumor activity of non-replicating Sendai virus particle against neuroblastoma (2013)
  • Author(s): Motonari Nomura
  • Journal Title: Cancer Science Volume: 104 Pages: 238-244
  • Peer Reviewed
• [Presentation] 神経芽腫に対する不活化ウイルス粒子 HVJ-E の抗腫瘍効果の検討 (2012)
  • Author(s): 野村 元成
  • Organizer: 第46回日本小児外科学会
  • Place of Presentation: 横浜
  • Year and Date: 2012-05-14
• [Presentation] 神経芽腫に対する不活化ウイルス粒子HVJ-Eの抗腫瘍効果の検討 (2012)
  • Author(s): 野村 元成
  • Organizer: 第49回日本小児外科学会学術集会
  • Place of Presentation: 横浜
• [Presentation] 骨髄転移、骨髄転移、腋窩リンパ節転移を来した前腕原発横紋筋肉腫の 1 例 (2011)
  • Author(s): 野村 元成
  • Organizer: 第26回日本小児がん学会
  • Place of Presentation: 大阪
  • Year and Date: 2011-12-17
• [Presentation] 頚部食道由来の胎児型横紋筋腫の1例 (2011)
  • Author(s): 野村元成
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 群馬
  • Year and Date: 2011-11-26
• [Presentation] 腹部膨満にて発見された、横隔膜浸潤と肺転移を伴ったWilms腫瘍の1例 (2011)
  • Author(s): 野村元成
  • Organizer: 第7回豊能広域こども急病センター小児疾患研究会
  • Place of Presentation: 大阪
  • Year and Date: 2011-08-20
• [Presentation] 門脈内進展をきたし AFP 高値のまま生体肝移植を実施した肝芽腫の1例 (2011)
  • Author(s): 野村 元成
  • Organizer: 第46回日本小児外科学会
  • Place of Presentation: 東京
  • Year and Date: 2011-07-20
• [Presentation] 門脈内進展をきたしAFP高値のまま生体肝移植を実施した肝芽腫の1例 (2011)
  • Author(s): 野村元成
  • Organizer: 第48回日本小児外科学会
  • Place of Presentation: 東京
  • Year and Date: 2011-07-20
• [Presentation] 骨髄転移、腋窩リンパ節転移を来した前腕原発横紋筋肉腫の1例 (2010)
  • Author(s): 野村元成
  • Organizer: 第26回日本小児がん学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-17