| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
The hedgehog(Hh) signaling pathway plays an important role in the growth and patterning in a variety of tissues during embryonic development. On the other hand, the activation of the Hh signal pathway due to mutations or ligand-dependent stimulation of the pathway is associated with tumorigenesis of a lot of cancers. This study revealed that 67-79% neuroblastoma samples showed positive for Hh proteins. There was a significant association between Oh signal proteins and the status of MYCN gene. The percentage of Oh protein positive cells in early stage samples was higher than that with advanced stage. The 5-year OS rate of Hh protein positive cases without MYCN amplification is significantly higher than that inGLI1 negative cases. Based on these result, the Hh signal proteins are possible to be a serum marker of neuroblastoma.
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