Study of AGEs and RAGE in the occurren ce of diabetic foot ulcer

• Project/Area Number: 22791718
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Plastic surgery
• Research Institution: University of Fukui
• Principal Investigator: YASUTA Masato 福井大学, 医学部・附属病院, 講師 (00362054)
• Research Collaborator: KUMAKIRI Masanobu 福井大学, 医学部, 教授 (60125309)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 創傷治癒 / AGEs / RAGE / 糖尿病性足潰瘍

Research Abstract

Hyperglycemia forms a substance known as Advanced glycation end products(AGEs), and AGEs cause damage in the diabetes complications. Diabetic foot ulcer is one of the diabetes complications. We confirmed that AGEs are in various part of a diabetic foot ulcer. Diabetic foot ulcer and wound healing delay may be caused by AGEs.