Expression and Pathogenic Role of Cartilage Oligomeric Matrix Protein(COMP) in Keloids

• Project/Area Number: 22791720
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Plastic surgery
• Research Institution: 公益財団法人田附興風会 (2011); Osaka University (2010)
• Principal Investigator: SHOUNO Fumie 公益財団法人田附興風会, 医学研究所第5研究部, 研究員 (30437412)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ケロイド / 同一個体 / COMP / TGF-β1 / コラーゲン / mRNA / 創傷治癒 / コラーゲンタイプI / タイプIコラーゲン / 同一人物 / 線維芽細胞

Research Abstract

We proved that keloid is continuously secreting COMP and Collagen out after the wound is healed. Then it was shown that the amounts of COMP secreted from keloid and from normal cells were almost the same by a simulation of early healing process using TGF-β1.Those results did not suggest that COMP itself increased Collagen production. By a transfection of COMP mRNA to both keloid cells and normal dermal cells, we found that COMP mRNA regulates collagen production. This is the first discovery of one of keloid specific biochemical regulation paths.

Research Products

• [Journal Article] Identification and characterization of cartilage oligomeric matrix protein as a novel pathogenic factor in keloids (2011)
  • Author(s): Inui Shigeki, Shono Fumie, Nakajima Takeshi, Hosokawa Kou, and Itami Satoshi
  • Journal Title: American Journal of Pathology Volume: 179(4) Pages: 1951-1960
  • Peer Reviewed
• [Presentation] Continuing Cartilage Oligomeric Matrix Protein(COMP) production in keloids for uncontrolled collagen accumulation (2011)
  • Author(s): Fumie Shono
  • Organizer: 16th International Congress of IPRAS(International Plastic Reconstructive & Aesthetic Surgery)
  • Place of Presentation: Vancouver Convention Center(Vancouver, Canada)
• [Presentation] Continuing Cartilage Oligomeric Matrix Protein (COMP) production in keloids for uncontrolled collagen accumulation (2011)
  • Author(s): 庄野文恵
  • Organizer: 16th International Congress of IPRAS (International Plastic Reconstructive & Aesthetic Surgery)
  • Place of Presentation: Vancouver Convention Center (Vancouver, Canada)
• [Presentation] Expression and Pathogenic Role of Cartilage Oligomeric Matrix Protein(COMP) in Keloids (2010)
  • Author(s): 庄野文恵
  • Organizer: International Scar Meeting in Tokyo 2010
  • Place of Presentation: 都市センターホテル・東京
  • Year and Date: 2010-11-30
• [Presentation] Expression and Pathogenic Role of Cartilage Oligomeric Matrix Protein (COMP) in Keloids (2010)
  • Author(s): 庄野文恵
  • Organizer: International Scar Meeting in Tokyo 2010
  • Place of Presentation: 都市センターホテル・東京
  • Year and Date: 2010-11-30
• [Presentation] ケロイドにおけるCOMP(cartilage oligomeric matrix protein)の同定と役割の解析 (2010)
  • Author(s): 庄野文恵
  • Organizer: 第19回日本形成外科学会基礎学術集会
  • Place of Presentation: パシフィコ横浜・横浜
  • Year and Date: 2010-09-15
• [Presentation] Expression and Pathogenic Role of Cartilage Oligomeric Matrix Protein(COMP) in Keloids (2010)
  • Author(s): Fumie Shono
  • Organizer: 第20回日中形成外科学会
  • Place of Presentation: 上海国際会議場・上海(中国)
  • Year and Date: 2010-08-26
• [Presentation] Expression and Pathogenic Role of Cartilage Oligomeric Matrix Protein (COMP) in Keloids (2010)
  • Author(s): 庄野文恵
  • Organizer: 第20回日中形成外科学会
  • Place of Presentation: 上海国際会議場・上海(中国)
  • Year and Date: 2010-08-26