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Study ofthe molecular mechanisms of delayed wound healing by using klothomice,which have phenotypessimilar to skin ulcerof aged humans.

Research Project

Project/Area Number 22791726
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Plastic surgery
Research InstitutionSapporo Medical University

Principal Investigator

YAMASHITA Ken  札幌医科大学, 医学部, 助教 (30312507)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords外科 / 老化 / 創傷治癒 / 皮膚潰瘍 / klothoマウス / klotho遺伝子 / 褥創
Research Abstract

The aim of this study was to analyze the molecular mechanisms of delayed wound healing with agingby using α-klotho-deficient (klotho) mice,which have phenotypessimilar to those of aged humans.Wound healing time, histology and mRNA expression were investigated using a skin defect wound model of klothomice. Theklotho mice showed delayed wound healingandimpairedgranulation formation compared to those in wild-type (WT) mice.The reverse transcript polymerase chain reaction (RT-PCR)analysis revealed enhancement of the mRNA expression of interleukin(IL)-1β, IL-6and tumor necrosis factor (TNF)-α, and depressionof laminin-5 in skin wound lesions of klotho mice compared to the levels in WT mice.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (1 results)

All 2012

All Presentation (1 results)

  • [Presentation] α-klotho欠損マウスの創傷治癒遷延に関する検討2012

    • Author(s)
      山内誠、池田佳奈枝、山下建、四ッ柳高敏、廣橋良彦、鳥越俊彦
    • Organizer
      第21回日本形成外科学会基礎学術集会
    • Place of Presentation
      福島県
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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