Hydrostatic Pressure-Loaded Cartilage Regeneration using Adipose-Derived Stem Cells

• Project/Area Number: 22791739
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Plastic surgery
• Research Institution: Nippon Medical School
• Principal Investigator: OGAWA Rei 日本医科大学, 医学部, 准教授 (70398866)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 再生医学 / 軟骨再生 / 静水圧 / 脂肪組織由来幹細胞 / コラーゲン / バイオプロセッサー / 力学的刺激 / メカノバイオロジー / 再生医療

Research Abstract

It was suggested that adipose-derived stem cells, collagen scaffolds, TGFβ and hydrostatic pressure are important for in vitro cartilage regeneration. However, it has also revealed that continuous mechanical forces are necessary to maintain the structure of implanted cartilage in vivo.

Research Products

• [Journal Article] 形成外科学とメカノバイオロジー(機械生物学)-物理的刺激が創傷治癒や組織再生に与える役割- (2012)
  • Author(s): 小川令, 黄晨〓, 佐野仁美, 赤石諭史, 宮崎邦夫, 百束比古, Orgill DP, 水野秀一
  • Journal Title: 日形会誌 Volume: 32 Pages: 137-143
  • NAID: 10030262256
• [Journal Article] Recent Patents on Stem Cell-Mediated Cartilage Regeneration and Repair (2011)
  • Author(s): Ogawa R.
  • Journal Title: Recent Patents on Regenerative Medicine Volume: 1 Issue: 1 Pages: 118-122
  • DOI: 10.2174/2210297311101010118
• [Journal Article] Recent Patents on Stem Cell-Mediated Cartilage Regeneration and Repair. (2011)
  • Author(s): Ogawa R
  • Journal Title: Recent Patents on Regenerative Medicine Volume: 1 Pages: 118-122
  • Peer Reviewed
• [Journal Article] Cartilage Regeneration Using Adipose-Derived Stem Cells. (2011)
  • Author(s): Ogawa R, Mizuno S
  • Journal Title: Curr Stem Cell Res Ther Volume: 5 Pages: 129-132
  • Peer Reviewed
• [Presentation] Cartilage Regeneration Using Adipose-Derived Stem Cells (2011)
  • Author(s): Ogawa R
  • Organizer: The 1^<st> International Conference on Adipose Tissue
  • Place of Presentation: Italy
  • Year and Date: 2011-11-24
• [Presentation] Utilizing Adipose Stem Cells for Cartilage Regenration in Plastic and Aesthetic Surgery (2011)
  • Author(s): Ogawa R.
  • Organizer: Aesthetic Asia 2011
  • Place of Presentation: Singapore
• [Presentation] Cartilage Regeneration Using Adipose-Derived Stem Cells (2011)
  • Author(s): Ogawa R.
  • Organizer: The 1^<st> International Conference on Adipose Tissue
  • Place of Presentation: Venice
• [Presentation] 創傷治癒・組織再生の方向性を転換する-20年後を考えた今、形成外科医にできる基礎研究とは- (2011)
  • Author(s): 小川令
  • Organizer: 第20回日本形成外科学会基礎学術集会
  • Place of Presentation: 東京
• [Presentation] Utilizing adipose stem cells for cartilage regeneration in plastic surgery (2010)
  • Author(s): Ogawa R
  • Organizer: The 2^<nd> Annual World Stem Cells & Regenerative Medicine Congress Asia 2010
  • Place of Presentation: Seoul
  • Year and Date: 2010-10-27