Development of the new cancer radical cure treatmentby the immune cells and the factor which control multiplicative growth and recjection of tumor cells in the skin.
| Project/Area Number |
22791740
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Plastic surgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
IBATA Minenori 大阪医科大学, 医学部, 非常勤医師 (20548359)
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| Research Collaborator |
YOSHIDA Ryotaro 大阪医科大学, 医学部, 教授 (10124760)
TASHIRO-YAMAJI Junko 大阪医科大学, 医学部, 講師 (40340559)
OKADA Masashi 大阪医科大学, 医学部, 講師 (10383283)
KUBOTA Takahiro 大阪医科大学, 医学部, 教授 (10084906)
UEDA Koichi 大阪医科大学, 医学部, 教授 (90257858)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 癌 / 免疫学 / マクロファージ / Meth A 線維肉腫細胞 / INF-γ / 細胞障害性 T リンパ球 / Meth A繊維肉腫細胞 / IFN-γ / 細胞傷害性Tリンパ球 / ワクチン効果 / I-10精巣癌細胞 / Meth A線維肉腫細胞 / 細胞障害性Tリンパ球 |
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| Research Abstract |
When the tumor cells were intradermally transplanted syngeneic of mice, the tumor cells were spontaneously rejected four sevenths of frequency, and the rejection required IFN- γ. In spontaneous rejiection of intradermally transplanted tumor cells did’induce infiltration of TAMs,the effector cells were macrophages and neutrophils and neither CTLs nor NK cells. The tumor cells were rejected from syngeneic mice sensitized intradermally once with them,the main effector cells were CTLs. The effect of intradermalimmunization was specific to the tumor cells transplanted in the skin.
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Report
(4 results)
Research Products
(6 results)
