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Development of the new cancer radical cure treatmentby the immune cells and the factor which control multiplicative growth and recjection of tumor cells in the skin.

Research Project

Project/Area Number 22791740
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Plastic surgery
Research InstitutionOsaka Medical College

Principal Investigator

IBATA Minenori  大阪医科大学, 医学部, 非常勤医師 (20548359)

Research Collaborator YOSHIDA Ryotaro  大阪医科大学, 医学部, 教授 (10124760)
TASHIRO-YAMAJI Junko  大阪医科大学, 医学部, 講師 (40340559)
OKADA Masashi  大阪医科大学, 医学部, 講師 (10383283)
KUBOTA Takahiro  大阪医科大学, 医学部, 教授 (10084906)
UEDA Koichi  大阪医科大学, 医学部, 教授 (90257858)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords癌 / 免疫学 / マクロファージ / Meth A 線維肉腫細胞 / INF-γ / 細胞障害性 T リンパ球 / Meth A繊維肉腫細胞 / IFN-γ / 細胞傷害性Tリンパ球 / ワクチン効果 / I-10精巣癌細胞 / Meth A線維肉腫細胞 / 細胞障害性Tリンパ球
Research Abstract

When the tumor cells were intradermally transplanted syngeneic of mice, the tumor cells were spontaneously rejected four sevenths of frequency, and the rejection required IFN- γ. In spontaneous rejiection of intradermally transplanted tumor cells did’induce infiltration of TAMs,the effector cells were macrophages and neutrophils and neither CTLs nor NK cells. The tumor cells were rejected from syngeneic mice sensitized intradermally once with them,the main effector cells were CTLs. The effect of intradermalimmunization was specific to the tumor cells transplanted in the skin.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] Spontaneous rejection of intradermally transplanted non-engineered tumor cells by neutrophils and macrophages from syngeneic strains of mice.(非処理の腫瘍細胞を同種同系マウスへ皮 内移植することでおこる好中球とマクロファージの関与する同種同 系腫瘍細胞の自然拒絶反応)2011

    • Author(s)
      Minenori Ibata, Takeshi Takahashi, Tetsunosuke Shimizu, Yoshihiro Inoue, Shogo Maeda, Junko Tashiro-Yamaji, Masashi Okada, Koichi Ueda, Takahiro Kubota, Ryotaro Yoshida1
    • Journal Title

      Microbiology and Immunology

      Volume: 55(10) Issue: 10 Pages: 726-735

    • DOI

      10.1111/j.1348-0421.2011.00369.x

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 腫瘍細胞と宿主細胞との相互作用:皮内への移植後、増殖し続ける腫瘍細胞と拒絶される腫瘍細胞2011

    • Author(s)
      前田尚吾、吉田龍太郎、井畑峰紀
    • Organizer
      第20回日本形成外科学会基礎学術集会
    • Place of Presentation
      ハイアットリージェンシー東京
    • Year and Date
      2011-10-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腫瘍細胞と宿主細胞との相互作用-皮内への移植後、増殖し続ける腫瘍細胞と 拒絶される腫瘍細胞-2011

    • Author(s)
      前田 尚吾、吉田 龍太郎、井畑 峰紀、高 橋 猛、山名秀典、山路 純子、窪田 隆裕、上田 晃一
    • Organizer
      第20回日本形成外科学会基礎学術集会
    • Place of Presentation
      ハイアットリージ ェンシー東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 線維肉腫細胞のマウス皮内免疫によるワクチン効果の腫瘍特異性について2010

    • Author(s)
      井畑峰紀
    • Organizer
      第19回 日本形成外科学会 基礎学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 線維肉腫細胞のマウス皮内接種によるワ クチン効果の抗原特異性について(Tumor specificity of vaccine effect by fibrosarcoma cells injected i.d. into mice)2010

    • Author(s)
      井畑 峰紀、吉田 龍太郎、高橋 猛、山路 純子、窪田 隆裕、上田 晃一
    • Organizer
      第19回日本形成外科学会基礎学術集会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] A cancer vaccine: Rejection of intraperitoneally (i.p.) transplanted syngeneic Meth A tumor cells by cytotoxic T lymphocytes from mice that had rejected intradermally (i.d.) injected Meth A tumor cells by a type of macrophages.Minenori Ibata, Takeshi Takahashi2010

    • Author(s)
      Junko Tashiro-Yamaji,Tetsunosuke Shimizu, Yoshihiro Inoue,Masashi Okada,Koichi Ueda,Takahiro Kubota,and Ryotaro Yoshida
    • Organizer
      14th international congress of immunology
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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