The relationship between plasma free DNA and the mortality and morbidity of ICU patients.

Research Project

Project/Area Number	22791748
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Emergency medicine
Research Institution	Kobe University
Principal Investigator	AOYAMA Michiko 神戸大学, 大学院・保健学研究科, 保健学研究員 (40566121)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords	外傷外科学 / 血漿遊離DNA / 敗血症 / 好中球 / 診断マーカー / 血漿遊離核酸濃度 / 生存率 / APACHEII / SOFA / 救命救急センター / SOFAスコア / APACHE IIスコア
Research Abstract	The plasma DNA concentration has been known to increase in the circulation of patients after trauma and may have prognostic potential. We examined the relevance of the plasma DNA concentration in ICU patients and their mortality. The average of plasma DNA concentrations for 3 days was higher, the mortality tended to be high in sepsis (p=0.08). In the non-septic patients, the plasma DNA concentrations of non-survived patients were higher than that of survived patients (p

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