The Development of New Therapy for Severe Left Ventricular Failure by Stem-cell Derived Chemokines

Research Project

Project/Area Number	22791750
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Emergency medicine
Research Institution	Kyushu University
Principal Investigator	HIASA Kenichi 九州大学, 大学病院, 助教 (00380452)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords	救急医学 / 集中治療医学 / 心筋新生
Research Abstract	To determine the role of mesenchymal stem cell(MSC), bone marrow. transferred wild-type mice with ubiquitous expression ofβ-galactosidase(LacZ) in the bone marrow(BMTLacZ→Wild) were used. Intravascular injection of mesenchymal stem cell revealed MSCs can mobilize, proliferate and differenciate to cardiac tissue. Injections of the expression plasmid containing SDF-1αpromoted1) mobilization of MSC to cardiac tissue, 2) proliferation and differentiation to cardiomyocyte and 3) improvement of LV systolic function.