Contribution of activated glia cells on the development of sepsis associated encephalopaty
| Project/Area Number |
22791751
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Emergency medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
TAKESHITA Jun 京都府立医科大学, 医学部附属病院, 専攻医 (40433263)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 集中治療医学 / 敗血症 |
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| Research Abstract |
We created animal model of sepsis suitable for behavioural analysis, including rat intraperitoneally injected lipopolysaccharide(LPS) and mouse treated with Cecal ligation and puncture(CLP). Brain tissue was taken from animals and performed immunohistochemsitry to investigate activation of glial cells during sepsis. In addition, expression level of cytokine mRNA was quantified by real time PCR. In septic animals, glial cells were found to be activated and the amount of pro-inflammatory cytokines increased in the brain.
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Report
(3 results)
Research Products
(3 results)
