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Contribution of activated glia cells on the development of sepsis associated encephalopaty

Research Project

Project/Area Number 22791751
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Emergency medicine
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

TAKESHITA Jun  京都府立医科大学, 医学部附属病院, 専攻医 (40433263)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords集中治療医学 / 敗血症
Research Abstract

We created animal model of sepsis suitable for behavioural analysis, including rat intraperitoneally injected lipopolysaccharide(LPS) and mouse treated with Cecal ligation and puncture(CLP). Brain tissue was taken from animals and performed immunohistochemsitry to investigate activation of glial cells during sepsis. In addition, expression level of cytokine mRNA was quantified by real time PCR. In septic animals, glial cells were found to be activated and the amount of pro-inflammatory cytokines increased in the brain.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (3 results)

All 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] 人工心肺離脱時の僧帽弁前尖収縮期前方運動(SAM)に対し異なった治療を施行した2症例2011

    • Author(s)
      竹下淳、中嶋康文、中山力恒、安本寛章、柴崎雅志、溝部俊樹
    • Journal Title

      Cardiovascular Anesthesia

      Volume: 15巻 Pages: 195-198

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 心臓手術後の心房細動発症抑制に対する塩酸ランジオロール少量持続投与の有用性2011

    • Author(s)
      竹下淳, 天谷文昌, 橋本壮志, 橋本悟, 佐和貞治
    • Organizer
      日本集中治療医学会
    • Year and Date
      2011-02-24
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 人工心肺離脱時に僧帽弁前尖収縮期前方運動(SAM)をみとめた2症例2010

    • Author(s)
      竹下淳, 中島康文, 松田愛, 安本寛章, 中山力恒, 柴崎雅志, 溝部俊樹, 橋本悟
    • Organizer
      日本心臓血管麻酔学会
    • Year and Date
      2010-10-10
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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