| Project/Area Number |
22791755
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Emergency medicine
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| Research Institution | Showa University |
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Principal Investigator |
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| Research Collaborator |
SHIODA Seiji 昭和大学, 医学部, 教授 (80102375)
ARUGA Tohru 昭和大学, 医学部, 教授 (40266086)
OHTAKI Hirokazu 昭和大学, 医学部, 助教 (20349062)
DOHI Kenji 昭和大学, 医学部, 講師 (20301509)
SATOH Kazue 昭和大学, 医学部, 名誉教授 (90053941)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 頭部外傷 / エダラボン / 活性酸素種 / 酸化ストレス / 神経細胞死 / Therapeutic time window / 二次性脳損傷 / ラジカルスカベンジャー / 二次的損傷 / 損傷周囲領域 |
|---|
| Research Abstract |
Mice were subjected to controlled cortical impact(CCI). Post-CCI, O_2^<・->production was obvious by3hours post-CCI, with oxidative stress and neuronal cell death becoming apparent after 6 hours. Therefore, edaravone (3.0mg/kg) or saline as a vehicle was administered intravenously either immediately (0hours) or 3 or 6 hours post-CCI. Administration of edaravone 0,3 or 6 hours post-CCI resulted in a significant reduction in the injury volume and level of oxidative stress compared with the control. The greatest decrease in O_2^<・->levels was observed when edaravone was administered 3 hours post-CCI. The current findings suggest that CCI produces excessive O_2^<・->, leading to oxidative stress and neuronal cell death. However these effects can be ameliorated by edaravone treatment, particularly if the drug is administered 3 hours post-CCI.
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