The scavengering effect of edaravone to nitric monoxide in mice traumatic brain injury
| Project/Area Number |
22791755
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Emergency medicine
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
SHIODA Seiji 昭和大学, 医学部, 教授 (80102375)
ARUGA Tohru 昭和大学, 医学部, 教授 (40266086)
OHTAKI Hirokazu 昭和大学, 医学部, 助教 (20349062)
DOHI Kenji 昭和大学, 医学部, 講師 (20301509)
SATOH Kazue 昭和大学, 医学部, 名誉教授 (90053941)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | 頭部外傷 / エダラボン / 活性酸素種 / 酸化ストレス / 神経細胞死 / Therapeutic time window / 二次性脳損傷 / ラジカルスカベンジャー / 二次的損傷 / 損傷周囲領域 |
|---|
| Research Abstract |
Mice were subjected to controlled cortical impact(CCI). Post-CCI, O_2^<・->production was obvious by3hours post-CCI, with oxidative stress and neuronal cell death becoming apparent after 6 hours. Therefore, edaravone (3.0mg/kg) or saline as a vehicle was administered intravenously either immediately (0hours) or 3 or 6 hours post-CCI. Administration of edaravone 0,3 or 6 hours post-CCI resulted in a significant reduction in the injury volume and level of oxidative stress compared with the control. The greatest decrease in O_2^<・->levels was observed when edaravone was administered 3 hours post-CCI. The current findings suggest that CCI produces excessive O_2^<・->, leading to oxidative stress and neuronal cell death. However these effects can be ameliorated by edaravone treatment, particularly if the drug is administered 3 hours post-CCI.
|
Report
(3 results)
Research Products
(50 results)
-
-
[Journal Article]2012
Author(s)
Hirokazu Ohtaki, Tomomi Tsumuraya, Dandan Song, Atsushi Sato, Kenji Ohara, Kazuyuki Miyamoto, Hiroyasu Nakano, Keisuke Kiriyama, Kenji Dohi, Yutaka Hiraizumi, Masaji Matsunaga, and Seiji Shioda
-
Journal Title
Neurochirugica supple
Volume: (In press)
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Regulation of Oxidative Stress by Pituitary AdenylateCyclase-Activating Polypeptide(PACAP) Mediated by PACAP Receptor2010
Author(s)
Ohtaki H, Satoh A, Nakamachi T, Yofu S, Dohi K, Mori H, Ohara K, Miyamoto K, Hashimoto H, Shintani N, Baba A, Matsunaga M, and Shioda S
-
Journal Title
J MolNeurosci
Volume: 42
Pages: 397-403
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
