| Project/Area Number |
22791765
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
USAMI Yu 大阪大学, 歯学部附属病院, 助教 (80444579)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 口腔病理学 / 口腔癌 / 扁平上皮癌 / 浸潤 / 転移 / 癌微小環境 / マクロファージ / ICAM-1 / 口腔扁平上皮癌 / intercellular adhesion molecule 1 |
|---|
| Research Abstract |
In this study, we evaluated the intercellular adhesion molecule-1(ICAM-1) expression in oral squamous cell carcinoma(OSCC). ICAM-1 expression was correlated with the invasiveness, lymph node metastasis, increased blood and lymphatic vessels, and macrophage infiltration. Moreover, macrophage/ OSCC-cell adhesion via ICAM-1 molecules was revealed. These findings indicate that ICAM-1 plays an important role in OSCC progression, which may result from the ICAM-1-induced the OSCC-cell activity and macrophage/ OSCC-cell adhesion.
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