| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
In this research project, functions of DKK3 gene were investigated in head and neck squamous cell carcinoma (HNSCC). Although DKK3 is reported to function as tumor suppressor in kinds of tumors, the present researches demonstrated contradict findings. In HNSCC, DKK3 mRNA and protein were dominantly expressed, unlike those in other cancers were attenuated or lost because of promoter methylation. Survival analyses revealed that DKK3 protein(-) patients showed longer survival. Knockdown of DKK3 mRNA by siRNA in HNSCC cell lines resulted in decreased cellular migration and invasion. All the data strongly imply the paradoxical function of DKK3 in HNSCC.
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