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The investigation on the function of c ementblast marker gene, f-spondin

Research Project

Project/Area Number 22791767
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionHiroshima University

Principal Investigator

KITAGAWA Masae  広島大学, 病院, 助教 (10403627)

Research Collaborator TAKATA Takashi  広島大学, 医歯薬学総合研究科, 教授 (10154783)
MIYAUCHI Mutsumi  広島大学, 医歯薬学総合研究科, 准教授 (50169265)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsセメント芽細胞 / F-spondin / 歯周組織 / トランスジェニックマウス
Research Abstract

To elucidate the function of f-spondin(SPON1) in the periodontal tissue, we researched in vivo and in vitro. In vivo, we made transgenic mouse(SPON1-Tg), and compared the amount of periapical cementum formation of SPON1-Tg with that of wild type. SPON1-Tg showed the slight increase of the cementum formation. In vitro, this experiment showed that expressions of OPN and BSP in human cementoblast-like cells(HCEM) were increased by BMP7 peptide. On the other hand, the expression of IL-6 and production of PGE2 induced by Aa-LPS in HCEM and SPON1 overexpessing HPL cells were significantly inhibited as compared with periodontal ligament cells. These results suggested the possibility that SPON1 would control not only the calcification but the inflammation.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (4 results)

All 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] F-spondin regulates the differentiation of human cementoblast-like(HCEM) cells via BMP7 expression2012

    • Author(s)
      Kitagawa M. et al
    • Journal Title

      BBRC

      Volume: 418 Pages: 229-233

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] F-spondin regulates the differentiation of human cementoblast-like (HCEM) cells via BMP7 expression2012

    • Author(s)
      北川雅恵
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 418 Pages: 229-233

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] F-spondin promotes thediffe rentiation of human periodontalligament cells2011

    • Author(s)
      Kitagawa M
    • Organizer
      The 4th HiroshimaConference on Education and Science inDentistry
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      2011-10-10
    • Related Report
      2011 Final Research Report
  • [Presentation] F-spondin promotes the differentiation of human periodontal ligament cells2011

    • Author(s)
      北川雅恵
    • Organizer
      The 4th Hiroshima Conference on Education and Science in Dentistry
    • Place of Presentation
      広島市
    • Year and Date
      2011-10-10
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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