| Project/Area Number |
22791767
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Research Collaborator |
TAKATA Takashi 広島大学, 医歯薬学総合研究科, 教授 (10154783)
MIYAUCHI Mutsumi 広島大学, 医歯薬学総合研究科, 准教授 (50169265)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | セメント芽細胞 / F-spondin / 歯周組織 / トランスジェニックマウス |
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| Research Abstract |
To elucidate the function of f-spondin(SPON1) in the periodontal tissue, we researched in vivo and in vitro. In vivo, we made transgenic mouse(SPON1-Tg), and compared the amount of periapical cementum formation of SPON1-Tg with that of wild type. SPON1-Tg showed the slight increase of the cementum formation. In vitro, this experiment showed that expressions of OPN and BSP in human cementoblast-like cells(HCEM) were increased by BMP7 peptide. On the other hand, the expression of IL-6 and production of PGE2 induced by Aa-LPS in HCEM and SPON1 overexpessing HPL cells were significantly inhibited as compared with periodontal ligament cells. These results suggested the possibility that SPON1 would control not only the calcification but the inflammation.
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