Tooth morphogenesis and the regulation of phosphate homeostasis : basic and preclinical studies of tooth hypoplasia
Project/Area Number |
22791768
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Morphological basic dentistry
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Research Institution | Hiroshima University |
Principal Investigator |
YOSHIOKA Hirotaka 広島大学, 大学院・医歯薬学総合研究科, 助教 (50523411)
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | リン酸代謝 / 歯牙形成 / 石灰化 / エナメル質 / 歯 |
Research Abstract |
Microarray analysis identified the odontogenesis-related genes influenced by inorganic phosphate(Pi) overload. Among the genes identified by microarray analysis, fibromodulin was downregulated in an extracellular Pi level-dependent manner in both cultured tooth germs and differentiated ameloblast lineage cells. This suppression of fibromodulin gene was dependent on ERK1/ 2-Egr1 signaling pathway in differentiated ameloblast lineage cells. These data suggest that the fibromodulin may be involved in the etiology of enamel hypoplasia caused by hyperphosphatemia.
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Report
(3 results)
Research Products
(21 results)
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[Presentation] Shimizu A, AubinJ, Maeda N. MEPE-Derived Phosphorylated ASARM Is Involved inFGF23/ soluble Klotho-DependentHypomineralization2011
Author(s)
Konishi Y, Yoshiko Y, Minamizaki T, Yoshioka H, Maeda M, Shimizu A, AubinJ, Maeda N
Organizer
The 33rd AnnualMeeting of the American Society forBone and Mineral Research
Place of Presentation
San Diego, CA, USA
Related Report
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