| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Research Abstract |
During the search for a regulatory mechanism of exfoliative toxin in Staphylococcus aureus, I found two novel transcriptional regulators and designated it SptA and SptB. This study suggest that the SptA globally regulates various pathogenic factors by suppressing the expression of RNAIII that is most important key factor for a production of pathogenic factors in S. aureus. On the other hand, SptB represses the expression of exfoliative toxin by directly binding to the internal region of exfoliative toxin gene. These results propose a novel regulatory mechanism for the production of staphylococcal pathogenic factors.
|
