The new strategy of the replacement therapy for prevention of dental caries
| Project/Area Number |
22791775
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 口腔細菌学 / 多糖分解酵素発現株 / リプレースメントセラピー / 齲蝕予防 / リプレイスメントセラピー / ムタナーゼ / 多糖分解酵素 / 齲蝕原性バイオフィルム / 多糖分解酵素産生菌 |
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| Research Abstract |
In order to construction of polysaccharide degradation enzymes producing bacteria for caries prevention by replacement therapy, we firstly identified and analyzed the genes encoding a mutanase (water insoluble glucan degradation enzyme). Secondarily, we constructed the bacterium which is overexpress of polysaccharide degradation enzymes by using plasmid-borne expression system.
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Report
(4 results)
Research Products
(11 results)
