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The new strategy of the replacement therapy for prevention of dental caries

Research Project

Project/Area Number 22791775
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionShowa University

Principal Investigator

TAKAHASHI Masakazu  昭和大学, 歯学部, 兼任講師 (40420921)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords口腔細菌学 / 多糖分解酵素発現株 / リプレースメントセラピー / 齲蝕予防 / リプレイスメントセラピー / ムタナーゼ / 多糖分解酵素 / 齲蝕原性バイオフィルム / 多糖分解酵素産生菌
Research Abstract

In order to construction of polysaccharide degradation enzymes producing bacteria for caries prevention by replacement therapy, we firstly identified and analyzed the genes encoding a mutanase (water insoluble glucan degradation enzyme). Secondarily, we constructed the bacterium which is overexpress of polysaccharide degradation enzymes by using plasmid-borne expression system.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (11 results)

All 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (8 results)

  • [Journal Article] Rapid detection and identification of Streptococcus ratti by a species-specific PCR method2011

    • Author(s)
      Nishio J, Taniguchi M, Higashi J, Takahashi M, Ando T, Hasegawa T, Igarashi T
    • Journal Title

      Anaerobe

      Volume: 18 Issue: 1 Pages: 44-47

    • DOI

      10.1016/j.anaerobe.2011.09.001

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid detection and identification of Streptococcus ratti by a species-specific PCR method2011

    • Author(s)
      Nishio J, Taniguchi M, Higashi J, Takahashi M, Ando T, Hasegawa T, Igarashi T
    • Journal Title

      Anaerobe

      Volume: 18 Pages: 44-47

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Analysis of the Nuclease Anchored to the Cell Wall of Streptococcus gordonii2010

    • Author(s)
      Takahashi M, Igarashi T
    • Journal Title

      Dental Medicine Research

      Volume: 30(3) Pages: 219-227

    • NAID

      10027973274

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Branched-chain Amino Acids Utilization by Streptococcus mutans2010

    • Author(s)
      Arimoto T, Taniguchi M, Takahashi M, Igarashi T
    • Organizer
      第58回国際歯科研究学会日本部会
    • Place of Presentation
      北九州
    • Year and Date
      2010-11-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Branched-chain Amino Acids Utilization by Streptococcus mutans2010

    • Author(s)
      T.Arimoto, M.Taniguchi, M.Takahashi, T.Igarashi
    • Organizer
      第58回国際歯科研究学会日本部会
    • Place of Presentation
      九州歯科大学
    • Year and Date
      2010-11-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] TLR2-dependent inflammatory response by Actinomyces viscosus is attenuated by naringenin2010

    • Author(s)
      Shimada E, Kataoka H, Takahashi M,Yamamoto M, Igarashi T
    • Organizer
      第96回アメリカ歯周病学会共催日本歯周病学会2010年大会
    • Place of Presentation
      ハワイ
    • Year and Date
      2010-10-30
    • Related Report
      2012 Final Research Report
  • [Presentation] TLR2-dependent inflammatory response by Actinomyces visucosus is attenuated by naringenin2010

    • Author(s)
      Eri Shimada, Hideo Kataoka, Masakazu Takahashi, Takeshi Igarashi, Matsuo Yamamoto
    • Organizer
      第96回アメリカ歯周病学会共催日本歯周病学会2010年大会
    • Place of Presentation
      ハワイコンベンションセンター
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prevotella intermediaのフルクタン代謝関連遺伝子群の解析2010

    • Author(s)
      布施晴香, 深町はるか, 高橋真和, 井上美津子, 五十嵐武
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prevotella intermedia のフルクタン代謝関連遺伝子群の解析2010

    • Author(s)
      布施晴香, 深町はるか,高橋真和,井上美津子,五十嵐武
    • Organizer
      第52回歯科基礎医学会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Actinomyces viscosusのリポタンパク質はTLR2を介した炎症応答を誘導する2010

    • Author(s)
      島田絵里,片岡嗣雄,高橋真和,山本松男,五十嵐武
    • Organizer
      第30回昭和歯学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Naringenin Suppresses the Inflammatory Response Induced by Staphylococcus aureus2010

    • Author(s)
      Shimada E, Kataoka H, Takahashi M,Yamamoto M, Igarashi T
    • Organizer
      110thAmerican society for microbiology general meeting
    • Place of Presentation
      サンディエゴ
    • Year and Date
      2010-03-23
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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