| Project/Area Number |
22791777
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 口腔病理学 / 口腔扁平上皮癌 / 癌幹細胞 / side population / Keratin4 / CD44 / CD24 / keratin15 / cancer stem cell / stem cell marker / niche / carcinogenesis |
|---|
| Research Abstract |
Cancer stem cells can be the source of all the malignant cells in a primary tumor, they can compose the small reservoir of drug-resistant cells that are responsible for relapse after a chemotherapy induced remission. In this study, we isolated oral cancer stem cell-like cells and the gene expression profile of oral cancer stem cell-like cells was examined. Our results demonstrate that the expression of keratin 34 could be a useful marker for pathologic diagnosis in terms of predicting malignant change and be a one of the makers for OSCC cancer stem cell.
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