| Project/Area Number |
22791782
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
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| Keywords | 移植・再生医療 / 再生医学 / 象牙質 / 発生・分化 |
|---|
| Research Abstract |
The majority of cells in the subodontoblastic layer express Thy-1.Therefore, to clarify the characteristics of cells in the subodontoblastic layer, the differentiation ability of Thy-1-positive cells into mineralizing cells was analyzed in vitro and in vivo. Following stimulation with BMP-2, Thy-1-positive dental pulp cells showed accelerated induction of ALP activity. Additionally, subcutaneous implantation of these positive cells induced numerous mineralized matrix formations. These results collectively suggest that Thy-1-positive dental pulp cells localized in the subodontoblastic layer have the ability to differentiate into hard tissue-forming cells.
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