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Dentin regeneration by Thy-1-positive dental pulp cells

Research Project

Project/Area Number 22791782
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

HOSOYA Akihiro  松本歯科大学, 歯学部, 講師 (70350824)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords移植・再生医療 / 再生医学 / 象牙質 / 発生・分化
Research Abstract

The majority of cells in the subodontoblastic layer express Thy-1.Therefore, to clarify the characteristics of cells in the subodontoblastic layer, the differentiation ability of Thy-1-positive cells into mineralizing cells was analyzed in vitro and in vivo. Following stimulation with BMP-2, Thy-1-positive dental pulp cells showed accelerated induction of ALP activity. Additionally, subcutaneous implantation of these positive cells induced numerous mineralized matrix formations. These results collectively suggest that Thy-1-positive dental pulp cells localized in the subodontoblastic layer have the ability to differentiate into hard tissue-forming cells.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (13 results)

All 2012 2011 2010

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (6 results)

  • [Journal Article] Thy-1-positive cells in the subodontoblastic layer possess high potential to differentiate into hard tissue-forming cells2012

    • Author(s)
      Akihiro Hosoya, Toru Hiraga, Tadashi Ninomiya, Akira Yukita, Kunihiko Yoshiba, Nagako Yoshiba, Susumu Ito, Hiroaki Nakamura
    • Journal Title

      Histochem Cell Biol

      Volume: 137(6) Pages: 733-742

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expressional Alterations of Fibrillin-1 during Wound Healing of Human Dental Pulp2012

    • Author(s)
      Nagako Yoshiba, Kunihiko Yoshiba, Naoto Ohkura, Akihiro Hosoya, Yoshimi Shigetani, Yusuke Yamanaka, Naoya Izumi, Hiroaki Nakamura, Takashi Okiji
    • Journal Title

      J Endodont

      Volume: 38(2) Pages: 177-184

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thy-1-positive cells in the subodontoblastic layer possess high potential to differentiate into hard tissue-forming cells2012

    • Author(s)
      Hosoya A.
    • Journal Title

      Histochem Cell Biol

      Volume: (In Press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of cytokeratins in the junctional region of ectoderm and endoderm2010

    • Author(s)
      Akihiro Hosoya, Sungwook Kwak, Eun-Jung Kim, Declan Patrick Lunny, E. Birgitte Lane, Sung-Won Cho, Han-Sung Jung
    • Journal Title

      Anat Rec(Hoboken)

      Volume: 293(11) Issue: 11 Pages: 1864-1872

    • DOI

      10.1002/ar.21233

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential of periodontal ligament cells to regenerate alveolar bone2010

    • Author(s)
      Akihiro Hosoya, Tadashi Ninomiya, Toru Hiraga, Kunihiko Yoshiba, Nagako Yoshiba, Etsuo Kasahara, Hidehiro Ozawa, Hiroaki Nakamura
    • Journal Title

      J Oral Biosci

      Volume: 52(2) Pages: 72-80

    • NAID

      10027105411

    • URL

      https://www.jstage.jst.go.jp/article/joralbiosci/52/2/52_2_72/_article

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential of periodontal ligament cells to regenerate alveolar bone2010

    • Author(s)
      Hosoya A.
    • Journal Title

      J Oral Biosci

      Volume: 52 Pages: 72-80

    • NAID

      10027105411

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of cytokeratins in the junctional region of ectoderm and endoderm2010

    • Author(s)
      Hosoya A.
    • Journal Title

      Anat Rec (Hoboken)

      Volume: 293 Pages: 1864-72

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Thy-1陽性subodontoblastic layer細胞の高い硬組織形成能2011

    • Author(s)
      細矢明宏, 平賀徹, 二宮禎, 雪田聡, 吉羽邦彦, 吉羽永子, 中村浩彰
    • Organizer
      第9回日本再生歯科医学会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Thy-1陽性subodontoblastic layer細胞の高い硬組織形成能2011

    • Author(s)
      細矢明宏
    • Organizer
      第9回日本再生歯科医学会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Thy-1(CD90)陽性歯髄細胞の硬組織形成能2011

    • Author(s)
      細矢明宏
    • Organizer
      第10回松本ボーンフォーラム
    • Place of Presentation
      松本歯科大学(塩尻)
    • Year and Date
      2011-05-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Thy-1陽性歯髄細胞の局在および硬組織形成能2010

    • Author(s)
      細矢明宏, 吉羽邦彦, 吉羽永子, 笠原悦男, 中村浩彰
    • Organizer
      第133回日本歯科保存学会・秋季学会
    • Place of Presentation
      長良川国際会議場(岐阜)
    • Year and Date
      2010-10-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Thy-1陽性歯髄細胞の硬組織形成能に関する形態学的研究2010

    • Author(s)
      細矢明宏, 平賀徹, 二宮禎, 雪田聡, 吉羽邦彦, 吉羽永子, 中村浩彰
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2010-09-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Thy-1陽性歯髄細胞の硬組織形成能に関する形態学的研究2010

    • Author(s)
      細矢明宏
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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