| Project/Area Number |
22791783
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Asahi University (2011-2012)
Aichi Gakuin University (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | Mfa1線毛 / PGN0291 / Porphyromonas gingivalis / 付随成分 / 歯周病関連菌 / P. gingivalis / 短線毛 / 微量成分 / 血小板凝集 / 自己凝集 / Mfal線毛 |
|---|
| Research Abstract |
The aim of this study was to elucidate the function of von Willebrand factor A domainlike protein (PGN0291), the accessory protein of Mfa1 fimbriae of P. gingivalis, inplatelet aggregation. The following findings were obtained although relationshipbetween PGN0291 protein and platelet aggregation were not found. 1. PGN0291 proteinwas required for assembly of other accessory proteins of PGN0289 and PGN0290. 2.PGN0291 protein was involved in P. gingivalis auto-aggregation. 3. PGN0289 proteinwas localized at tip of fimbriae. These findings indicate that PGN0289, PGN0290 andPGN0291, the accessory proteins of Mfa1 fimbriae, form the complex at the tip, andare important for function of Mfa1 fimbriae.
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