Identification of mechanosensitive channels responded to hypo-osmotic stress in the osteoblast
| Project/Area Number |
22791785
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
YOSHIDA Takashi 東北大学, 大学院・歯学研究科, 助教 (30455795)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 骨芽細胞 / カルシウム / 機械刺激 / チャネル / 機械的刺激 |
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| Research Abstract |
Mechanical stress plays a vital role in maintaining bone architecture. The process by which osteoblasts convert mechanical signal into biochemical responses leading to bone remodeling is not fully understood. In spite of the significant role of mechanosensitive channels in osteoblast, the molecular identity of mechanosensitive channels remains unknown. When we applied the hypo-osmotic stress in the presence of extracellular Ca^(2+), some cells were responded. But specific TRPV2 or TRPV4 siRNA could not inhibit Ca^(2+)response by hypo-osmotic stress. These results indicate that TRPV2 or TRPV4 channels are not candidate for the hypo-osmotic stress responding channel in osteoblast.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] A missense mutation of the gene encoding voltage-dependent sodium channel (Nav1. 1)confers susceptibility to febrile seizures in rats.2010
Author(s)
Mashimo, T., Ohmori, I., Ouchida, M., Ohno, Y., Tsurumi, T., Miki, T., Wakamori, M., Ishihara, S., Yoshida, T., Takizawa, A., Kato, M., Hirabayashi, M., Sasa, M., Mori, Y. and Serikawa, T.
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Journal Title
J. Neurosci
Volume: 30巻
Pages: 5744-5753
Related Report
Peer Reviewed
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[Journal Article] A missense mutation of the gene encoding voltage-dependent sodium channel (Na_v1.1) confers susceptibility to febrile seizures in rats2010
Author(s)
Mashimo, T., Ohmori, I., Ouchida, M., Ohno, Y., Tsurumi, T., Miki, T., Wakamori, M., Ishihara, S., Yoshida, T., Takizawa, A., Kato, M., Hirabayashi, M., Sasa, M., Mori, Y., Serikawa, T
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Journal Title
J.Neurosci.
Volume: 30
Pages: 5744-5753
Related Report
Peer Reviewed
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