Research Project
Grant-in-Aid for Young Scientists (B)
Mechanical stress plays a vital role in maintaining bone architecture. The process by which osteoblasts convert mechanical signal into biochemical responses leading to bone remodeling is not fully understood. In spite of the significant role of mechanosensitive channels in osteoblast, the molecular identity of mechanosensitive channels remains unknown. When we applied the hypo-osmotic stress in the presence of extracellular Ca^(2+), some cells were responded. But specific TRPV2 or TRPV4 siRNA could not inhibit Ca^(2+)response by hypo-osmotic stress. These results indicate that TRPV2 or TRPV4 channels are not candidate for the hypo-osmotic stress responding channel in osteoblast.
All 2012 2011 2010
All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (9 results)
J. Neurosci
Volume: 30巻 Pages: 5744-5753
J.Neurosci.
Volume: 30 Pages: 5744-5753
