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The analysis of binding of CTGF/CCN2 to RANK and its effects on RANK/RANKL signaling

Research Project

Project/Area Number 22791788
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionOkayama University

Principal Investigator

AOYAMA Eriko  岡山大学, 大学院・医歯薬学総合研究科, 助教 (10432650)

Research Collaborator TAKIGAWA Masaharu  岡山大学, 大学院・医歯薬学総合研究科, 教授 (20112063)
KUBOTA Satoshi  岡山大学, 大学院・医歯薬学総合研究科, 准教授 (90221936)
NISHIDA Takashi  岡山大学, 大学院・医歯薬学総合研究科, 助教 (30322233)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsCTGF/CCN2 / RANK / OPG / RANKL / RAW264. 7 / SPR / MAPK / RAW264.7 / osteoclast / CCN2/CTGF / RANK/RANKL/OPG
Research Abstract

CCN2/CTGF which is a member of CCN2 family proteins binds to various cytokines and modulates the effects. We screened the binding proteins to CCN2/CTGF and found receptor activator of NF-kappaB(RANK). CCN2/CTGF also could bind to OPG which was a decoy receptor and inhibited the effect of RANK. In the RAW264. 7, preosteoclast, CCN2/CTGF augmented the stimulation of RANKL(RANK ligand) and attenuated the inhibitory effect of OPG on RANK/RANKL signaling. These data showed that CCN2/CTGF enhanced differentiation of osteoclast via two different pathways.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (11 results)

All 2011 2010

All Presentation (11 results)

  • [Presentation] Receptor activator of NF-κB(RANK)結合タンパク質であるCCN2/CTGFのRANKL誘導性破骨細胞形成における機能2011

    • Author(s)
      青山絵理子, 久保田聡, 西田崇, 滝川正春
    • Organizer
      第32回岡山歯学会
    • Place of Presentation
      岡山
    • Year and Date
      2011-11-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Receptor activator of NF-kB (RANK)結合タンパク質であるCCN2/CTGFのRANKL誘導性破骨細胞形成における機能2011

    • Author(s)
      青山絵理子、久保田聡、西田崇、滝川正春
    • Organizer
      第32回岡山歯学会
    • Place of Presentation
      岡山
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] The function of CCN2/CTGF, a receptor activator of NF-kB(RANK)-binding protein, in RANKL-induced osteoclastgenesis2011

    • Author(s)
      青山絵理子, 久保田聡, 西田崇, 滝川正春
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] CCN2のRANK(receptor activator of nuclear factor kappa B)の結合とRANK-RANKLシグナル制御作用2011

    • Author(s)
      青山絵理子, 久保田聡, 西田崇, 滝川正春
    • Organizer
      第4回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2011 Final Research Report
  • [Presentation] RANK結合タンパク質CCN2/CTGFはRANK-RANKLシグナルを促進する2011

    • Author(s)
      青山絵理子, 久保田聡, 西田崇, 滝川正春
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] CCN2のRANK (receptor activator of nuclear factor kappa B)の結合とRANK-RANKLシグナル制御作用2011

    • Author(s)
      青山絵理子、久保田聡、西田崇、滝川正春
    • Organizer
      第4回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2011 Annual Research Report
  • [Presentation] The role of CCN2/CTGF binding to receptor activator of NF-κB(RANK) in the RANK-RANK ligand system2010

    • Author(s)
      Eriko Aoyama, Satoshi Kubota, Takashi Nishida, Masaharu Takigawa
    • Organizer
      第33回日本分子生物学会年会,第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] CCN2/CTGFとRANKの分子間相互作用の解析と骨代謝における意義2010

    • Author(s)
      青山絵理子, 久保田聡, 滝川正春
    • Organizer
      第28回日本骨代謝学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] CCN2/CTGFとRANKの分子間相互作用の解析と骨代謝における意義Analysis of the interaction between CCN2/CTGF and RANK2010

    • Author(s)
      青山絵理子、久保田聡、滝川正春
    • Organizer
      第28回日本骨代謝学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGF BINDS TO FIBROBLAST GROWTH FACTOR RECEPTOR 2 AND MODULATES ITS SIGNALING2010

    • Author(s)
      Eriko Aoyama, Satoshi Kubota, Masaharu Takigawa
    • Organizer
      6TH INTERNATIONAL WORKSHOP ON THE CCN FAMILY OF GENES
    • Place of Presentation
      Newcastle, Northern Ireland
    • Related Report
      2010 Annual Research Report
  • [Presentation] The role of CCN2/CTGF binding to receptor activator of NF-κB (RANK) in the RANK-RANK ligand system2010

    • Author(s)
      青山絵理子、久保田聡、滝川正春
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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