Mechanisms of cancer-induced pain in orofacial cancer model of rats
| Project/Area Number |
22791794
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
ONO Kentaro 九州歯科大学, 歯学部, 准教授 (40316154)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 顔面癌 / 三叉神経節 / ミクログリア / アストロサイト / 口腔顔面癌 / 疼痛モデル / 神経細胞 / GFP / タンパク定量 / プロペントフィリン / グリア細胞 / トレーサー |
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| Research Abstract |
Since orofacial cancer-induced pain causes difficulties in eating, the symptoms of patients with orofacial cancer may be more severe than those of patients with cancer in other regions. In the present study, we investigated mechanism of cancer-induced pain in a rat facial cancer model. Consequently, we have demonstrated that cancer-induced pain is caused by central glial hyper-activation, independently on inflammation and nerve injury. The result suggests that anti-glial activation drugs may be available to inhibit cancer-induced pain in clinical side.
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Report
(3 results)
Research Products
(64 results)
