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Neural mechanisms underlying the improvement of blood flow in the jaw muscles evoked by vagal afferent stimulation

Research Project

Project/Area Number 22791796
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

ISHII Hisayoshi  北海道医療大学, 歯学部, 講師 (00275489)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords副交感神経 / 血管拡張反応 / 迷走神経 / 孤束核 / GABA受容体 / 咀嚼筋 / 中枢神経 / 中枢神経系 / 求心性刺激 / 末梢性神経機構
Research Abstract

The present study examined the neural mechanisms underlying the improvement of blood flow in the masseter muscle evoked by vagal afferent stimulation. Our results indicate that cervical vagus nerve stimulation elicits the increase of blood flow in the rat masseter muscle mediated by vagal-parasympathetic reflex vasodilatation, and suggest that nucleus of the solitary tract play an important role in the blood flow increase in the jaw muscles.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (28 results)

All 2012 2011 2010 Other

All Journal Article (11 results) (of which Peer Reviewed: 10 results) Presentation (14 results) Remarks (3 results)

  • [Journal Article] GABA_B receptors in the NTS mediate the inhibitory effect of trigeminal nociceptive inputs on parasympathetic reflex vasodilation in the rat masseter muscle2012

    • Author(s)
      Ishii H and Izumi H.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 302 Issue: 6 Pages: R776-R784

    • DOI

      10.1152/ajpregu.00569.2011

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] GABA_B receptors in the NTS mediate the inhibitory effect of trigeminal nociceptive inputs on parasympathetic reflex vasodilation in the rat masseter muscle2012

    • Author(s)
      Ishii H, Izumi H
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 302

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anterior hypothalamic inhibition of reflex parasympathetic vasodilatation in the lower lip and palate of anaesthetized cats2011

    • Author(s)
      Izumi H, Ishii H and Mizuta K.
    • Journal Title

      Dent J Health Sci Univ Hokkaido

      Volume: 30 Pages: 43-52

    • NAID

      120005434154

    • URL

      http://www.hoku-iryo-u.ac.jp/?dental-society/

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] レーザースペックル血流計による血流動態のイメージング解析2011

    • Author(s)
      新岡丈治、石井久淑、和泉博之
    • Journal Title

      北医療大歯誌(総説)

      Volume: 30 Pages: 9-21

    • NAID

      120005429296

    • URL

      http://www.hoku-iryo-u.ac.jp/?dental-society/

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Parasympathetic reflex vasodilatationin the masseter muscle compensates forcarotid hypoperfusion during thevagus-mediated depressor response2011

    • Author(s)
      Ishii H, Niioka T and Izumi H.
    • Journal Title

      Brain Res

      Volume: 1370 Pages: 145-153

    • DOI

      10.1016/j.brainres.2010.11.046

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] レーザースペックル血流計による血流動態のイメージング解析2011

    • Author(s)
      新岡丈治、石井久淑、和泉博之
    • Journal Title

      北医療大歯誌

      Volume: 30(総説) Pages: 9-21

    • NAID

      120005429296

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 咀嚼筋の自律神経性血流調節に関する末梢性及び中枢性神経機構2010

    • Author(s)
      石井久淑、和泉博之
    • Journal Title

      自律神経(総説)

      Volume: 47 Pages: 340-349

    • NAID

      10026906136

    • URL

      http://www.jsnr-net.jp/

    • Related Report
      2011 Final Research Report
  • [Journal Article] Vasodilator responses mediated by autonomic nervous system in the jaw muscles2010

    • Author(s)
      Ishii H and Izumi H.
    • Journal Title

      Dent J Health Sci Univ Hokkaido(Review)

      Volume: 29 Pages: 1-23

    • NAID

      120005429226

    • URL

      http://www.hoku-iryo-u.ac.jp/?dental-society/29-1.pdf

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vagalvisceral inputs to the nucleus of thesolitary tract : involvement in aparasympathetic reflex vasodilatorpathway in the rat masseter muscle2010

    • Author(s)
      Ishii H, Niioka T and Izumi H.
    • Journal Title

      Brain Res

      Volume: 1312 Pages: 41-53

    • DOI

      10.1016/j.brainres.2009.11.073

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vasodilator responses mediated by autonomic nervous system in the jaw muscles2010

    • Author(s)
      Ishii H, Izumi H
    • Journal Title

      Dent J Health Sci Univ Hokkaido

      Volume: 29(Review) Pages: 1-23

    • NAID

      120005429226

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 咀嚼筋の自律神経性血流調節に関する末梢性及び中枢性神経機構2010

    • Author(s)
      石井久淑
    • Journal Title

      自律神経

      Volume: 47(総説) Pages: 340-349

    • NAID

      10026906136

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] GABA_B receptors in the NTS mediate the inhibitory effect of trigeminal nociceptive inputs on parasympathetic reflex vasodilation in the rat masseter muscle2012

    • Author(s)
      Ishii H and Izumi H.
    • Organizer
      The Proceedings of the 89th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Nagano, Matsumoto Bunka Kaikan
    • Year and Date
      2012-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] GABA_B receptors in the NTS mediate the inhibitory effect of trigeminal nociceptive inputs on parasympathetic reflex vasodilation in the ratmasseter muscle2012

    • Author(s)
      Ishii H, Izumi H
    • Organizer
      The Proceedings of the 89th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      松本市総合体育館(Nagano)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 三叉神経領域の侵害入力による咀嚼筋の副交感神経性血管拡張反応の抑制作用2011

    • Author(s)
      石井久淑、和泉博之
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      岐阜、長良川国際会議場
    • Year and Date
      2011-10-01
    • Related Report
      2011 Final Research Report
  • [Presentation] 三叉神経領域の侵害入力による咀嚼筋の副交感神経性血管拡張反応の抑制作用2011

    • Author(s)
      石井久淑、和泉博之
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      長良川国際会議場(岐阜)
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Imaging analysis of parasympathetic vasodilatation in vasa nervorum ofrat facial nerve with laser speckle imaging flowmeter2011

    • Author(s)
      Niioka T, Ishii H and Izumi H.
    • Organizer
      The Proceedings of the 88th Annual Meeting of the Physiological Society of Japan and the 116th Annual Meeting of the Japanese Association of Anatomists
    • Place of Presentation
      Kanagawa, PACIFICO YOKOHAMA
    • Year and Date
      2011-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Imaging analysis of parasympathetic vasodilatation in vasa nervorum of rat facial nerve with laser speckle imaging flowmeter2011

    • Author(s)
      Niioka T, Ishii H, Izumi H
    • Organizer
      The Proceedings of the 88th Annual Meeting of the Physiological Society of Japan and the 116th Annual Meeting of the Japanese Association of Anatomists
    • Place of Presentation
      パシフィコ横浜(横浜、神奈川県)
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Parasympathetic masseter vasodilatation compensates for carotid hypoperfusion2011

    • Author(s)
      Izumi H, Ishii H and Niioka T.
    • Organizer
      89th General session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      San Diego, USA, San Diego Convention Center
    • Year and Date
      2011-03-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Parasympathetic masseter vasodilatation compensates for carotid hypoperfusion2011

    • Author(s)
      Izumi H, Ishii H, Niioka T
    • Organizer
      89th General session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      San Diego Convention Center (San Diego, USA)
    • Year and Date
      2011-03-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 咀嚼筋の副交感神経性血管拡張反応は顔面・頭部領域の血流維持に関与する2010

    • Author(s)
      石井久淑、新岡丈治、和泉博之
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      東京、タワーホール船堀
    • Year and Date
      2010-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 咀嚼筋の副交感神経性血管拡張反応は顔面・頭部領域の血流維持に関与する2010

    • Author(s)
      石井久淑、新岡丈治、和泉博之
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Involvement of visceral inputs in vasodilatation in the masseter muscle2010

    • Author(s)
      Izumi H, Ishii H and Niioka T.
    • Organizer
      88th General session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Spain, Centre de Convencions Internacional Barcelona
    • Year and Date
      2010-07-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Involvement of visceral inputs in vasodilatation in the masseter muscle2010

    • Author(s)
      Ishii H, Niioka T, Izumi H
    • Organizer
      88th General session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Centre de Convencions Internacional Barcelona (Barcelona, Spain)
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Involvement of vagal visceral inputs to the nucleus of the solitary tractin parasympathetic reflex vasodilatation in the rat masseter muscle2010

    • Author(s)
      Ishii H, Niioka T and Izumi H.
    • Organizer
      The Proceedings of the 87th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Iwate, Morioka Civic Cultural Hall
    • Year and Date
      2010-05-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Involvement of vagal visceral inputs to the nucleus of the solitary tract in parasympathetic reflex vasodilatation in the rat masseter muscle2010

    • Author(s)
      Ishii H, Niioka T, Izumi H
    • Organizer
      The Proceedings of the 87th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      いわて県民情報交流センター(盛岡、岩手県)
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.hoku-iryo-u.ac.jp/?physiol/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.hoku-iryo-u.ac.jp/~physiol/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.hoku-iryo-u.ac.jp/~physiol/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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