Functions of Cdc42 during skeletal development
| Project/Area Number |
22791798
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Research Collaborator |
KAMIJO Ryutaro 昭和大学, 歯学部, 教授 (70233939)
SUZUKI Dai 昭和大学, 歯学部, 助教 (00585797)
AIZAWA Ryo 昭和大学, 歯学部, 大学院生
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 遺伝子 / 細胞・組織 / 発生・分化 / シグナル伝達 / chondrogenesis / limb development / Rho GTPase / BMP |
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| Research Abstract |
Cdc42, a member of the Rho subfamily of small GTPases, is known to be a regulator of multiple cellular functions, including cytoskeletal organization, cell migration, proliferation, and apoptosis. To investigate the physiological function of Cdc42 during limb development, we generated limb bud mesenchyme-specific inactivated Cdc42(Cdc42^<fl/fl>; Prx1-Cre) mice. Cdc42^<fl/fl>; Prx1-Cre mice demonstrated short limbs and body, abnormal calcification of the cranium, cleft palate, disruption of the xiphoid process, and syndactyly. Syndactyly in Cdc42^<fl/fl>; Prx1-Cre mice was caused by fusion of metacarpals and a failure of interdigital programmed cell death(ID-PCD). These results demonstrate that Cdc42 is essential for chondrogenesis and ID-PCD during limb development.
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Report
(3 results)
Research Products
(49 results)
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[Presentation] BMP活性制御因子の探索とその機能解析2011
Author(s)
山田篤, 塚崎雅之, 鈴木大, 相澤怜, 宮園あがさ, 山本松男, 上條竜太郎
Organizer
昭和大学大学院歯学研究科・口腔癌包括的研究センター平成22年度合同シンポジウム
Place of Presentation
東京
Year and Date
2011-03-26
Related Report
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[Presentation] Essential role of Cdc42 in chondrogenesis and interdigital programmed cell death during limb development2011
Author(s)
Ryo Aizawa, Atsushi Yamada, Dai Suzuki, Hidetoshi Kassai, Takeshi Harada, Masayuki Tsukasaki, Gou Yamamoto, Tadahiro Iimura, Akira Yamaguchi, Kazuki Nakao, Matsuo Yamamoto, Atsu Aiba, Ryutaro Kamijo
Organizer
The 33th Annual Meeting of the American Society for Bone and Mineral Research
Place of Presentation
San Diego, California, USA
Related Report
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[Presentation] TNF-αSuppresses POEM Expression in Osteoblasts2011
Author(s)
Tsukasaki M, Yamada A, Miyazono A, Suzuki D, Yoshimura K, Aizawa R, Miyamoto Y, Takami M, Suzawa T, Morimura N, Aruga J, Yamamoto M, Kamijo R
Organizer
89^<th> General Session & Exhibition of the International Associate for Dental Research(IADR)
Place of Presentation
San Diego, California, USA
Related Report
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[Presentation] Alx3, a Paired-type Homeodomein Containing Transcription Factor, Regulates Osteoblast Differentiation Induced by BMP-2.2010
Author(s)
Matsumoto T, Yamada A, Suzuki D, Takami M, Suzawa T, Miyamoto Y, Baba K, Kamijo R
Organizer
The 32nd Annual Meeting of the American Society for Bone and Mineral Research
Place of Presentation
Toronto, Canada
Related Report
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