| Project/Area Number |
22791799
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Functional basic dentistry
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
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| Keywords | 関節軟骨 / 再生医学 / 細胞・組織 / 遺伝子 / 軟骨 / Wnt/β-catenin |
|---|
| Research Abstract |
The surface of articular cartilage is covered with unique cells called superficial cells. To keep maintaining articular function under the loaded circumstances, it is important to activate superficial cells. The aim of this study is to investigate the characteristics of superficial cells, and the pathological and recovery mechanisms in articular cartilage injuries. This study found that the superficial cells had undifferentiated chondro progenitor cell-like properties, that was controlled by Wnt/β-catenin signaling using gain-and loss of function of β-catenin model mice.
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