Study on the physiological roles of toll-like receptors in inflammatory bone destruction
Project/Area Number |
22791801
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Functional basic dentistry
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Research Institution | Showa University |
Principal Investigator |
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 骨 / 破骨細胞 / 樹状細胞 / 細胞分化 / 炎症 / 免疫 / Toll-like receptor / RANKL / 炎症性骨疾患 / 分化振り分け因子 / IRF5 / IRF8 / STAT5 / マクロファージ / 炎症性骨破壊 / 遺伝子改変マウス |
Research Abstract |
Identification and characterization of osteoclastogenesis regulatory factors will be useful for development of therapeutic approach for inflammatory bone diseases. We found that signal transducers and activators of transcription(STAT) 5, which is a transcription factor has the potential to play an important role for suppressing osteoclast differentiation. These results will contribute to development for bone metabolism research and medicine for inflammatory diseases.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts2012
Author(s)
Miyamoto A, Takami M, Matsumoto A, Mochizuki A, Yamada T, Tachi K, Shibuya I, Nakamachi T, Shioda S, Baba K, Inoue T, Miyamoto Y, Yim M, Kamijo R
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Journal Title
Related Report
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[Journal Article] R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature2012
Author(s)
Miyamoto A, Takami M, Matsumoto A, Mochizuki A, Yamada T, Tachi K, Shibuya I, Nakamachi T, Shioda S, Baba K, Inoue T, Miyamoto Y, Yim M
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Journal Title
Cytotechnology
Volume: (印刷中)(取得中)
Related Report
Peer Reviewed
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[Journal Article] Decreased Intake of Sucrose Solutions in Orexin Knockout Mice2011
Author(s)
Matsuo E, Mochizuki A, Nakayama K, Nakamura S, Yamamoto T, Shioda S, Sakurai T, Yanagisawa M, Shiuchi T, Minokoshi Y, Inoue T
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Journal Title
J Mol Neurosci
Volume: 43
Pages: 217-224
Related Report
Peer Reviewed
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[Journal Article] Enhancement of bone morphogenetic protein-2-induced ectopic bone formation by transforming growth factor-β12011
Author(s)
Tachi K, Takami M, Sato H, Mochizuki A, Zhao B, Miyamoto Y, Tsukasaki H, Inoue T, Shintani S, Koike T, Honda Y, Suzuki O, Baba K, Kamijo R
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Journal Title
Tissue Eng Part A
Volume: 17
Pages: 597-606
Related Report
Peer Reviewed
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[Journal Article] Decreased Intake of Sucrose Solutions in Orexin Knockout Mice.2011
Author(s)
Mochizuki A, Matsuo E, Nakayama K, Nakamura S, Yamamoto T, Shioda S, Sakurai T, Yanagisawa M, Shiuchi T, Minokoshi Y, Inoue T
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Journal Title
Journal of Molecular Neuroscience
Volume: 43(2)
Pages: 217-224
Related Report
Peer Reviewed
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[Journal Article] Enhancement of bone morphogenetic protein-2-induced ectopic bone formation by transforming growth factor-β1.2011
Author(s)
Tachi K, Takami M, Sato H, Mochizuki A, Zhao B, Miyamoto Y, Tsukasaki H, Inoue T, Shintani S, Koike T, Honda Y, Suzuki O, Baba K, Kamijo R.
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Journal Title
Tissue Engineering Part A.
Volume: 17(5-6)
Pages: 597-606
Related Report
Peer Reviewed
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[Presentation] Electrophysiological and morphological properties of premotor neurons targeting jaw-closing and jaw-opening motoneurons2011
Author(s)
Inoue T, Nakamura S, Gemba-Nishimura A, Nonaka M, Yoshida A, Mochizuki A, Nakayama K
Organizer
NANOSYMPOSIUM ; Orofacial Systems : Respiration, Communication, and Feeding ; Theme D : Sensory and Motor Systems, Neuroscience
Place of Presentation
Washington, DC
Related Report
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