The role os IL-18 and Th17 cells in the T cell related immune system of Sjogren's syndrome
| Project/Area Number |
22791806
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pathobiological dentistry/Dental radiology
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
SAKAI AZUSA 東北大学, 大学病院, 医員 (90463778)
|
|---|
| Project Period (FY) |
2010-04-01 – 2013-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | シェーグレン症候群 / 唾液腺 / IL-18 / Th17 / サイトカイン |
|---|
| Research Abstract |
The purpose of this research was to investigate the pathogenesis of Sjogren's syndrome. The expression of IL-18 and IL-17 were detected in salivary glands of Sjogren's syndrome, and infiltrating T cells. IL-18 amplified the secretion of IL-8 and IL-6 induced by low amounts of IL-17 from primary salivary glands cells. The results suggest that IL-18 and Th17 cells are associated with the pathogenesis of Sjogren's syndrome.
|
Report
(4 results)
Research Products
(6 results)
