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The role os IL-18 and Th17 cells in the T cell related immune system of Sjogren's syndrome

Research Project

Project/Area Number 22791806
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionTohoku University

Principal Investigator

SAKAI AZUSA  東北大学, 大学病院, 医員 (90463778)

Project Period (FY) 2010-04-01 – 2013-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsシェーグレン症候群 / 唾液腺 / IL-18 / Th17 / サイトカイン
Research Abstract

The purpose of this research was to investigate the pathogenesis of Sjogren's syndrome. The expression of IL-18 and IL-17 were detected in salivary glands of Sjogren's syndrome, and infiltrating T cells. IL-18 amplified the secretion of IL-8 and IL-6 induced by low amounts of IL-17 from primary salivary glands cells. The results suggest that IL-18 and Th17 cells are associated with the pathogenesis of Sjogren's syndrome.

Report

(4 results)
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] 東北大学病院歯科部門における外来患者の動向-臨床研修ならびに臨床教育に対する意識調査-2014

    • Author(s)
      酒井梓, 飯久保正弘, 嶋田雄介, 橋本直哉, 熊坂晃, 佐々城真, 遠藤雄, 小嶋郁穂, 庄司憲明, 笹野高嗣
    • Journal Title

      日本口腔診断学会雑誌

      Volume: 27 Pages: 8-12

    • NAID

      130003398164

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 東北大学病院歯科部門における外来患者の動向ー臨床研修ならびに臨床教育に対する意識調査ー2014

    • Author(s)
      酒井梓, 飯久保正弘, 嶋田雄介, 橋本直也, 熊坂晃, 佐々城真, 遠藤雄, 小嶋郁穂, 庄司憲明, 笹野高嗣
    • Journal Title

      日本口腔診断学会雑誌

      Volume: 27 Pages: 7-12

    • NAID

      130003398164

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] MRI of submandibular and sublingual glands in patients with Sjogren's syndrome and its diagnostic significance2013

    • Author(s)
      Ikuho Kojima, Maya Sakamoto, Iikubo Masahiro, Azusa Sakai, Yumiko Sugawara, Sizuko Satoh, Takashi Sasano
    • Organizer
      Part 3 : Diagnostic accuracy about high intensity spots on MR-sialography and heterogeneity of MR signal intensity
    • Place of Presentation
      東京
    • Year and Date
      2013-11-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Diagnostic ability to detect high signal intensity spots on MRsialography in patient with Sjogren's syndrome : Comparison between 3D and 2D methods2013

    • Author(s)
      Ikuho Kojima, Maya Sakamoto, Iikubo Masahiro, Azusa Sakai, Yumiko Sugawara, Sizuko Satoh, Takashi Sasano
    • Place of Presentation
      東京
    • Year and Date
      2013-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] MRI of the sunmandibular and sublingual glands in patients with Sjogren's syndrome and its diagnostic significance2013

    • Author(s)
      Ikuho Kojima, Maysa Sakamoto, Masahiro Iikubo, Azusa Sakai, Yumiko Sugawara, Shizuko Satoh-Kuriwada, Takashi Sasano
    • Organizer
      第18回 日本歯科放射線学会臨床画像大会
    • Place of Presentation
      一橋記念講堂(東京都千代田区)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Diagnostic ability to detect high signal intensity spots on MR sialography in patients with Sjogren's syndrome: Comparison between 3D and 2D methods2013

    • Author(s)
      Ikuho Kojima, Maysa Sakamoto, Masahiro Iikubo, Azusa Sakai, Yumiko Sugawara, Shizuko Satoh-Kuriwada, Takashi Sasano
    • Organizer
      第26回 日本口腔診断学会・第23回 日本口腔内科学会合同学術大会
    • Place of Presentation
      一橋記念講堂(東京都千代田区)
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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