The role os IL-18 and Th17 cells in the T cell related immune system of Sjogren's syndrome

• Project/Area Number: 22791806
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Tohoku University
• Principal Investigator: SAKAI AZUSA 東北大学, 大学病院, 医員 (90463778)
• Project Period (FY): 2010-04-01 – 2013-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: シェーグレン症候群 / 唾液腺 / IL-18 / Th17 / サイトカイン

Research Abstract

The purpose of this research was to investigate the pathogenesis of Sjogren's syndrome. The expression of IL-18 and IL-17 were detected in salivary glands of Sjogren's syndrome, and infiltrating T cells. IL-18 amplified the secretion of IL-8 and IL-6 induced by low amounts of IL-17 from primary salivary glands cells. The results suggest that IL-18 and Th17 cells are associated with the pathogenesis of Sjogren's syndrome.

Research Products

• [Journal Article] 東北大学病院歯科部門における外来患者の動向-臨床研修ならびに臨床教育に対する意識調査- (2014)
  • Author(s): 酒井梓, 飯久保正弘, 嶋田雄介, 橋本直哉, 熊坂晃, 佐々城真, 遠藤雄, 小嶋郁穂, 庄司憲明, 笹野高嗣
  • Journal Title: 日本口腔診断学会雑誌 Volume: 27 Pages: 8-12
  • NAID: 130003398164
  • Peer Reviewed
• [Journal Article] 東北大学病院歯科部門における外来患者の動向ー臨床研修ならびに臨床教育に対する意識調査ー (2014)
  • Author(s): 酒井梓， 飯久保正弘， 嶋田雄介， 橋本直也， 熊坂晃， 佐々城真， 遠藤雄， 小嶋郁穂， 庄司憲明， 笹野高嗣
  • Journal Title: 日本口腔診断学会雑誌 Volume: 27 Pages: 7-12
  • NAID: 130003398164
  • Peer Reviewed
• [Presentation] MRI of submandibular and sublingual glands in patients with Sjogren's syndrome and its diagnostic significance (2013)
  • Author(s): Ikuho Kojima, Maya Sakamoto, Iikubo Masahiro, Azusa Sakai, Yumiko Sugawara, Sizuko Satoh, Takashi Sasano
  • Organizer: Part 3 : Diagnostic accuracy about high intensity spots on MR-sialography and heterogeneity of MR signal intensity
  • Place of Presentation: 東京
  • Year and Date: 2013-11-02
• [Presentation] Diagnostic ability to detect high signal intensity spots on MRsialography in patient with Sjogren's syndrome : Comparison between 3D and 2D methods (2013)
  • Author(s): Ikuho Kojima, Maya Sakamoto, Iikubo Masahiro, Azusa Sakai, Yumiko Sugawara, Sizuko Satoh, Takashi Sasano
  • Place of Presentation: 東京
  • Year and Date: 2013-09-13
• [Presentation] MRI of the sunmandibular and sublingual glands in patients with Sjogren's syndrome and its diagnostic significance (2013)
  • Author(s): Ikuho Kojima, Maysa Sakamoto, Masahiro Iikubo, Azusa Sakai, Yumiko Sugawara, Shizuko Satoh-Kuriwada, Takashi Sasano
  • Organizer: 第18回 日本歯科放射線学会臨床画像大会
  • Place of Presentation: 一橋記念講堂（東京都千代田区）
• [Presentation] Diagnostic ability to detect high signal intensity spots on MR sialography in patients with Sjogren's syndrome: Comparison between 3D and 2D methods (2013)
  • Author(s): Ikuho Kojima, Maysa Sakamoto, Masahiro Iikubo, Azusa Sakai, Yumiko Sugawara, Shizuko Satoh-Kuriwada, Takashi Sasano
  • Organizer: 第26回 日本口腔診断学会・第23回 日本口腔内科学会合同学術大会
  • Place of Presentation: 一橋記念講堂（東京都千代田区）