Roles of an immunoregulatory molecule B7-H1 in pathogenesis of periodontitis

• Project/Area Number: 22791809
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KAMIMURA Yosuke 東京医科歯科大学, 大学院・医歯学総合研究科, 非常勤講師 (40549929)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 免疫 / 感染 / 炎症 / 免疫学 / 歯学 / 歯周病 / 補助シグナル分子 / PD-1 / B7-H1

Research Abstract

Proliferative responses of keratinocytes in the skin and the gingiva that overexpressed an immunoregulatory molecule B7-H1 were accelerated. Early inflammatory skin responses were suppressed by B7-H1 on keratinocytes in a PD-1-dependent manner, but the inflammatory responses in the gingiva were impaired. A murine model of periodontitis was induced by a TDC60 strain of Prophyromonas gingivalis. Serum titers of TDC60-specific IgG were markedly elevated in the mice that exhibited severe alveolar bone loss.

Research Products

• [Journal Article] B7-H1 overexpression regulates epithelial-mesenchymal transition and accelerates carcinogenesis in skin (2011)
  • Author(s): Cao Y, Zhang L, Kamimura Y, Ritprajak P, Hashiguchi M, Hirose S, Azuma M
  • Journal Title: Cancer Res Volume: 71(4) Pages: 1235-43
• [Journal Article] Immunoregulatory molecules B7-H1(CD274) contributes to skin carcinogenesis (2011)
  • Author(s): Cao Y, Zhang L, Ritprajak P, Tsushima F, Youngnak-Piboonratanakit P, Kamimura Y, Hashiguchi M, Azuma M
  • Journal Title: Cancer Res Volume: 71 Pages: 4737-4741
• [Journal Article] B7-H1 overexpression regulates epithelial-mesenchymal transition and accelerates carcinogenesis in skin (2011)
  • Author(s): Cao Y, Zhang L, Kamimura Y, Ritprajak P, Hashiguchi M, Hirose S, Azuma M
  • Journal Title: Cancer Res Volume: 71 Issue: 4 Pages: 1235-43
  • DOI: 10.1158/0008-5472.can-10-2217
  • Peer Reviewed
• [Journal Article] Immunoregulatory molecules B7-H1 (CD274) contributes to skin carcinogenesis (2011)
  • Author(s): Cao Y, Zhang L, Ritprajak P, Tsushima F, Youngnak-Piboonratanakit P, Kamimura Y, Hashiguchi M, Azuma M
  • Journal Title: Cancer Res Volume: 71 Issue: 14 Pages: 4737-4741
  • DOI: 10.1158/0008-5472.can-11-0527
  • Peer Reviewed
• [Journal Article] B7-H1 overexpression regulates epithelial-mesenchymal transition and accelerates carcinogenesis in skin. (2011)
  • Author(s): Cao Y.
  • Journal Title: Cancer Research Volume: 15 Pages: 1235-43
  • Peer Reviewed
• [Journal Article] Immunoregulatory molecules B7-H1 (CD274) contributes to skin carcinogenesis. (2011)
  • Author(s): Cao Y.
  • Journal Title: Cancer Research Volume: (in press)
  • Peer Reviewed